TY - CHAP AU - Utpal Bhadra AU - Debabani Roy Chowdhury AU - Tanmoy Mondal and Manika Pal Bhadra ED - Ibrokhim Y. Abdurakhmonov Y1 - 2016-04-06 PY - 2016 T1 - Long Noncoding RNAs are Frontier Breakthrough of RNA World and RNAi-based Gene Regulation N2 - RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional longstanding obstacles in life sciences. RNAi research and application have significantly advanced during past two decades. This book RNA interference provides an updated knowledge and progress on RNAi in various organisms, explaining basic principles, types, and property of inducers, structural modifications, delivery systems/methodologies, and various successful bench-to-field or clinic applications and disease therapies with some aspects of limitations, alternative tools, safety, and risk assessment. BT - RNA Interference SP - Ch. 4 UR - https://doi.org/10.5772/61975 DO - 10.5772/61975 SN - 978-953-51-2272-2 PB - IntechOpen CY - Rijeka Y2 - 2024-05-11 ER -