TY  - CHAP
AU  - Zhenzhen Liu
AU  - Peifu Li
AU  - Jiannan Wu
AU  - Yi Wang
AU  - Ping Li
AU  - Xinxin Hou
AU  - 
Qingling Zhang
AU  - Nannan Wei
AU  - Zhiquan Zhao
AU  - Huimin Liang and
Jianshe Wei
ED  - Inga Zerr
Y1  - 2015-07-01
PY  - 2015
T1  - The Cascade of Oxidative Stress and Tau Protein Autophagic Dysfunction in Alzheimer’s Disease
N2  - There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.
BT  - Alzheimer's Disease
SP  - Ch. 2
UR  - https://doi.org/10.5772/59980
DO  - 10.5772/59980
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-25
ER  -