TY - CHAP AU - Federica Ganci AU - Andrea Sacconi AU - Valentina Manciocco AU - Giuseppe Spriano AU - Giulia Fontemaggi AU - Paolo Carlini AU - Giovanni Blandino ED - Loredana G. Marcu Y1 - 2015-07-08 PY - 2015 T1 - Radioresistance in Head and Neck Squamous Cell Carcinoma — Possible Molecular Markers for Local Recurrence and New Putative Therapeutic Strategies N2 - While the management of head and neck cancer has evolved over the last few decades, there are still several challenges and unanswered questions that need solutions. This book is a small compilation of some topical aspects regarding head and neck cancer treatment, including the etiology of HPV-positive oropharyngeal cancers and risk factors in the young population, the challenge of surgical margin definition and the perennial problem of systemic treatment due to distant metastases. Radiobiological aspects are also covered through the Rs of radiotherapy, with a couple of chapters being dedicated to radioresistance and tumour microenvironment. Contemporary Issues in Head and Neck Cancer Management comes as an addition to the existing literature that aims to tackle this radiobiologically challenging tumour. BT - Contemporary Issues in Head and Neck Cancer Management SP - Ch. 1 UR - https://doi.org/10.5772/60081 DO - 10.5772/60081 SN - PB - IntechOpen CY - Rijeka Y2 - 2024-04-25 ER -