TY  - CHAP
AU  - Francois Bernier
AU  - Pavan Kumar
AU  - Yoshiaki Sato
AU  - Yoshiya Oda
ED  - Inga Zerr
Y1  - 2015-07-01
PY  - 2015
T1  - Recent Progress in the Identification of Non-Invasive Biomarkers to Support the Diagnosis of Alzheimer’s Disease in Clinical Practice and to Assist Human Clinical Trials
N2  - There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.
BT  - Alzheimer's Disease
SP  - Ch. 8
UR  - https://doi.org/10.5772/60008
DO  - 10.5772/60008
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-26
ER  -