TY  - CHAP
AU  - Genaro Gabriel Ortiz
AU  - Fermín P. Pacheco-Moisés
AU  - Erika D. González-
Renovato
AU  - Luis Figuera
AU  - Miguel A. Macías-Islas
AU  - Mario Mireles-
Ramírez
AU  - L. Javier Flores-Alvarado
AU  - Angélica Sánchez-López
AU  - Dhea G.
Nuño-Penilla
AU  - Irma E. Velázquez- Brizuela
AU  - Juan P. Sánchez-Luna
and Alfredo Célis de la Rosa
ED  - Inga Zerr
Y1  - 2015-07-01
PY  - 2015
T1  - Genetic, Biochemical and Histopathological Aspects of Familiar Alzheimer's Disease
N2  - There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.
BT  - Alzheimer's Disease
SP  - Ch. 10
UR  - https://doi.org/10.5772/59809
DO  - 10.5772/59809
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-24
ER  -