TY  - CHAP
AU  - Luis Oskar Soto-Rojas
AU  - Fidel de la Cruz-López
AU  - Miguel Angel
Ontiveros Torres
AU  - Amparo Viramontes-Pintos
AU  - María del Carmen
Cárdenas-Aguayo
AU  - Marco A. Meraz-Ríos
AU  - Citlaltepetl Salinas-Lara
AU  - 
Benjamín Florán-Garduño
AU  - José Luna-Muñoz
ED  - Inga Zerr
Y1  - 2015-07-01
PY  - 2015
T1  - Neuroinflammation and Alteration of the Blood-Brain Barrier in Alzheimer´s Disease
N2  - There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.
BT  - Alzheimer's Disease
SP  - Ch. 3
UR  - https://doi.org/10.5772/60024
DO  - 10.5772/60024
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-25
ER  -