TY  - CHAP
AU  - Christelle Freitas
AU  - Alexandre Bignon
AU  - Karl Balabanian
AU  - Ali Dalloul
ED  - Sabine Wislet-Gendebien
Y1  - 2014-08-01
PY  - 2014
T1  - CXCR4 in Central and Peripheral Lymphoid Niches – Physiology, Pathology and Therapeutic Perspectives in Immune Deficiencies and Malignancies
N2  - Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell.  The objectives of this book would be to review the molecular mechanisms  that mediate the balanced response  of stem cells to the needs of the organisms.  Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets.  Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease.  The third objective would be to review the therapeutical targets described within stem cell niches.
BT  - Adult Stem Cell Niches
SP  - Ch. 3
UR  - https://doi.org/10.5772/58699
DO  - 10.5772/58699
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-16
ER  -