TY - CHAP AU - Jens K. Habermann AU - Gert Auer AU - Madhvi Upender AU - Timo Gemoll AU - Hans-Peter Bruch AU - Hans JoĢˆrnvall AU - Uwe J. Roblick AU - Thomas Ried ED - Zuzana Storchova Y1 - 2012-05-16 PY - 2012 T1 - Aneuploidy and Epithelial Cancers: The Impact of Aneuploidy on the Genesis, Progression and Prognosis of Colorectal and Breast Carcinomas N2 - Aneuploidy means any karyotype that is not euploid, anything that stands outside the norm. Two particular characteristics make the research of aneuploidy challenging. First, it is often hard to distinguish what is a cause and what is a consequence. Secondly, aneuploidy is often associated with a persistent defect in maintenance of genome stability. Thus, working with aneuploid, unstable cells means analyzing an ever changing creature and capturing the features that persist. In the book Aneuploidy in Health and Disease we summarize the recent advances in understanding the causes and consequences of aneuploidy and its link to human pathologies. BT - Aneuploidy in Health and Disease SP - Ch. 5 UR - https://doi.org/10.5772/36616 DO - 10.5772/36616 SN - PB - IntechOpen CY - Rijeka Y2 - 2024-04-26 ER -