TY - CHAP AU - Fotios Dimitriadis AU - Dimitrios Baltogiannis AU - Sotirios Koukos AU - Dimitrios Giannakis AU - Panagiota Tsounapi AU - Georgios Seminis AU - Motoaki Saito AU - Atsushi Takenaka AU - Nikolaos Sofikitis ED - Anu Bashamboo ED - Kenneth David McElreavey Y1 - 2012-04-20 PY - 2012 T1 - The Role of PDE5 Inhibitors in the Treatment of Testicular Dysfunction N2 - Male infertility is a multifaceted disease where genetic, epigenetic and environmental factors all contribute to the development of the phenotype. In recent years, there has been an increasing concern about a decline in reproductive health, paralleled by an increase in demand for infertility treatments. This calls for a detailed and thorough understanding of normal and aberrant testicular function and the environmental influences on the establishment and integrity of the male germ cell. This is crucial for understanding the complex pathophysiology of male infertility and eventual success of Assisted Reproductive Technologies. BT - Male Infertility SP - Ch. 4 UR - https://doi.org/10.5772/32501 DO - 10.5772/32501 SN - PB - IntechOpen CY - Rijeka Y2 - 2024-04-25 ER -