TY  - CHAP
AU  - Nicola Tinari
AU  - Michele De Tursi
AU  - Antonino Grassadonia
AU  - Marinella Zilli
AU  - Stefano Iacobelli
AU  - Clara Natoli
ED  - Sanjay K. Srivastava
Y1  - 2012-03-23
PY  - 2012
T1  - New Targets for Therapy in Pancreatic Cancer
N2  - This book provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer. Book also summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail.  Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5-flourouracil.
BT  - Pancreatic Cancer
SP  - Ch. 7
UR  - https://doi.org/10.5772/27344
DO  - 10.5772/27344
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-16
ER  -