TY - CHAP AU - Sonja Pavlovic AU - Branka Zukic AU - Gordana Nikcevic ED - Despina Sanoudou Y1 - 2012-03-21 PY - 2012 T1 - Pharmacogenomics of Thiopurine S-Methyltransferase: Clinical Applicability of Genetic Variants N2 - The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response. These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments. This book presents Pharmacogenetic examples from a broad spectrum of different drugs, for different diseases, which are representative of different stages of evaluation or application. It has been designed so as to serve both the unfamiliar reader through explanations of basic Pharmacogenetic concepts, the clinician with presentation of the latest developments and international guidelines, and the research scientist with examples of Pharmacogenetic applications, discussions on the limitations and an outlook on the new scientific trends in this field. BT - Clinical Applications of Pharmacogenetics SP - Ch. 4 UR - https://doi.org/10.5772/26588 DO - 10.5772/26588 SN - PB - IntechOpen CY - Rijeka Y2 - 2024-03-29 ER -