TY  - CHAP
AU  - Ayssar A. Elamin
AU  - Matthias Stehr
AU  - Mahavir Singh
ED  - Pere-Joan Cardona
Y1  - 2012-02-15
PY  - 2012
T1  - The Cord Factor: Structure, Biosynthesis and Application in Drug Research – Achilles Heel of Mycobacterium tuberculosis?
N2  - In 1957, a Streptomyces strain, the ME/83 (S.mediterranei), was isolated in the Lepetit Research Laboratories from a soil sample collected at a pine arboretum near Saint Raphael, France. This drug was the base for the chemotherapy with Streptomicine. The euphoria generated by the success of this regimen lead to the idea that TB eradication would be possible by the year 2000. Thus, any further drug development against TB was stopped. Unfortunately, the lack of an accurate administration of these drugs originated the irruption of the drug resistance in Mycobacterium tuberculosis. Once the global emergency was declared in 1993, seeking out new drugs became urgent. In this book, diverse authors focus on the development and the activity of the new drug families.
BT  - Understanding Tuberculosis
SP  - Ch. 8
UR  - https://doi.org/10.5772/32032
DO  - 10.5772/32032
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-24
ER  -