TY  - CHAP
AU  - William E. Acree
AU  - Jr.
AU  - Laura M. Grubbs
AU  - Michael H. Abraham
ED  - William Acree
Y1  - 2012-02-10
PY  - 2012
T1  - Prediction of Toxicity, Sensory Responses and Biological Responses with the Abraham Model
N2  - Modern drug design and testing involves experimental in vivo and in vitro measurement of the drug candidate's ADMET (adsorption, distribution, metabolism, elimination and toxicity) properties in the early stages of drug discovery.  Only a small percentage of the proposed drug candidates receive government approval and reach the market place.  Unfavorable pharmacokinetic properties, poor bioavailability and efficacy, low solubility, adverse side effects and toxicity concerns account for many of the drug failures encountered in the pharmaceutical industry.  Authors from several countries have contributed chapters detailing regulatory policies, pharmaceutical concerns and clinical practices in their respective countries with the expectation that the open exchange of scientific results and ideas presented in this book will lead to improved pharmaceutical products.
BT  - Toxicity and Drug Testing
SP  - Ch. 12
UR  - https://doi.org/10.5772/29972
DO  - 10.5772/29972
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-18
ER  -