TY  - CHAP
AU  - Hitomi Matsunari
AU  - Masahito Watanabe
AU  - Kazuhiro Umeyama
AU  - Kazuaki Nakano
AU  - Yuka Ikezawa
AU  - Mayuko Kurome Barbara Kessler
AU  - Eckhard Wolf
AU  - Shuji Miyagawa
AU  - Hiromitsu Nakauchi
AU  - Hiroshi Nagashima
ED  - Shuji Miyagawa
Y1  - 2012-02-03
PY  - 2012
T1  - Cloning of Homozygous a1,3-Galactosyltransferase Gene Knock-Out Pigs by Somatic Cell Nuclear Transfer
N2  - Accompanied by the advent of animal cloning, the technique of nuclear transfer produced alpha1,3-galactosyltransferase-knockout (Gal-KO) pigs in many institutes, including the ones in Japan, at the beginning of 21st Century. In addition, the controversy of the risks of PERV has gradually minimized, because of the fact that there are no cases of PERV infections reported in humans. Furthermore, a large clinical wave for islet allotransplantation resumed the interest of xenotransplantation, especially porcine islet transplantation and some exceptions. Clinical trials were done in many countries so far, such as Sweden, China, Mexico, USA  (Inventory of Human Xenotransplantation Practices - IXA and HUG in collaboration with WHO). In addition, a new clinical trial was approved by the government, and resumed the porcine islet transplantation research in New Zealand two years ago.
BT  - Xenotransplantation
SP  - Ch. 3
UR  - https://doi.org/10.5772/29267
DO  - 10.5772/29267
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-25
ER  -