TY  - CHAP
AU  - George Leondaritis
AU  - Xenia Koliou
AU  - Shalini Johnson
AU  - 
Chengjun Li
AU  - Andreas Florakis
AU  - Konstantinos Dimas
AU  - Nikos Sakellaridis
AU  - Dimitra Mangoura
ED  - Hiroyuki Shimada
Y1  - 2012-02-08
PY  - 2012
T1  - Interplay Between Protein Kinase C Isoforms Alpha and Epsilon, Neurofibromin, and the Ras/MAPK Pathway in Neuroblastoma Differentiation
N2  - Neuroblastoma, once called "enigmatic", due to "unpredictable" clinical behaviors, is composed of biologically diverse tumors. Molecular/genomic properties unique to the individual tumors closely link to the clinical outcomes of patients. Establishing risk stratification models after analyzing biologic characteristics of each case has made a great success in patient management. However, the trend of improving survival rates in neuroblastoma over the last 30 years has started to level off, and currently available treatment modalities have almost reached to their maximized intensity. Furthermore, aggressive treatment causes significant long-term morbidities to the survivors. We really need to make the next step to the level of personalized medicine with more precise understanding of neuroblastoma biology. This book includes useful data and insights from the world's experts in this field. I believe this book can make an excellent contribution to all the investigators working hard and fighting for the children stricken by this disease.
BT  - Neuroblastoma
SP  - Ch. 5
UR  - https://doi.org/10.5772/27810
DO  - 10.5772/27810
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-19
ER  -