TY  - CHAP
AU  - Galina S. Bogatkevich
AU  - Kristin B. Highland
AU  - Tanjina Akter
AU  - Paul J. Nietert
AU  - Ilia Atanelishvili
AU  - Joanne van Ryn
AU  - Richard M. Silver
ED  - Timothy Radstake
Y1  - 2012-02-03
PY  - 2012
T1  - Inhibition of Thrombin as a Novel Strategy in the Treatment of Scleroderma-Associated Interstitial Lung Disease
N2  - Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has yet to be determined: endothelial dysfunction, autoantibody formation, and activation of fibroblasts. This current book provides up-to-date information on the pathogenesis and clinical features of this severe syndrome. It is our hope that this book will aid both clinicians and researchers in dealing with patients with this clinical syndrome. In addition, we hope to shed more light on this rare and severely disabling syndrome, ultimately leading to better research and successful therapeutic targeting.
BT  - Systemic Sclerosis
SP  - Ch. 8
UR  - https://doi.org/10.5772/25568
DO  - 10.5772/25568
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-24
ER  -