TY  - CHAP
AU  - C. Vandenbriele
AU  - A. Vassou
AU  - G. Pentheroudakis
AU  - K. Van Calsteren
AU  - F. Amant
ED  - Mariastefania Antica
Y1  - 2011-12-22
PY  - 2011
T1  - Hematologic Malignancies in Pregnancy
N2  - This book provides a comprehensive overview of  he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease. The first section discusses the classification of acute leukemia, taking into account diagnoses  dependent on techniques that are essential, and thankfully readily available, in the laboratory. The second section concerns recent advances in molecular biology, markers, receptors, and signaling molecules responsible for disease progression, diagnostics based on biochips and other molecular genetic analysis. These advances provide clinicians with important understanding and improved decision making towards the most suitable therapy for acute leukemia. Biochemical, structural, and genetic studies may bring a new era of epigenetic based drugs along with additional molecular targets that will form the basis for novel treatment strategies. Later in the book, pediatric acute leukemia is covered, emphasizing that children are not small adults when it comes to drug development. The last section is a collection of chapters about treatment, as chemotherapy-induced toxicity is still a significant clinical concern. The present challenge lies in reducing the frequency and seriousness of adverse effects while maintaining efficacy and avoiding over-treatment of patients.
BT  - Acute Leukemia
SP  - Ch. 16
UR  - https://doi.org/10.5772/21922
DO  - 10.5772/21922
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-16
ER  -