TY  - CHAP
AU  - Agostino Tafuri et
AU  - Michele Milella
AU  - Stefano Iacovelli
AU  - Fabiana De Cave
AU  - Chiara Gregorj
AU  - Paola Bergamo
AU  - Andrea Miele
AU  - Roberto Licchetta
AU  - Marina Konopleva
AU  - James A. McCubrey
AU  - Alberto M. Martelli
AU  - Robin Foà
AU  - Maria Teresa Petrucci
AU  - Maria Rosaria Ricciardi
ED  - Stefan Faderl
Y1  - 2011-11-16
PY  - 2011
T1  - Aberrant Proliferative and Apoptotic Pathways in Acute Lymphoblastic Leukemia (ALL): Molecular Therapies to Overcome Chemo-Resistance
N2  - Acute lymphoblastic leukemia (ALL) has turned from a universally fatal to a highly curable disease in little more than four decades. Even though differences in outcome continue to exist between children and adults, intense efforts are under way to overcome this discrepancy and improve the prognosis of adult patients as well. This exemplary progress in ALL therapy has been possible by the combination of an increasingly better understanding of the biology of the disease, availability of a range of effective drugs, and astute designs and relentless executions of many clinical trials. ALL is a complex disease requiring complex therapy. Whereas this book cannot provide a comprehensive review of every one of its many facets, the chapters from many investigators from around the world nevertheless cover a number of relevant topics: aspects of the epidemiology of ALL in Hispanics, ophthalmologic manifestations of ALL, overviews of current therapy and drug-resistance mechanisms, novel biological pathways and targets, new drugs in development, and long-term consequences of CNS prophylaxis and therapy. The publishers and editor therefore hope that the prospective readers will find enough insight and information for their own endeavors.
BT  - Novel Aspects in Acute Lymphoblastic Leukemia
SP  - Ch. 9
UR  - https://doi.org/10.5772/28114
DO  - 10.5772/28114
SN  - 
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-25
ER  -