TY - CHAP AU - Keiichi Higuchi AU - Xiaoying Fu AU - Pengyao Zhang AU - Jinko Sawashita AU - Beiru Zhang AU - Jinze Qian AU - Wang Yaoyong AU - Masayuki Mori ED - Svetlana Sarantseva Y1 - 2011-09-22 PY - 2011 T1 - Mouse Models to Study Systemic Amyloidoses: Is Prion-Like Transmission a Common Pathogenic Mechanism? N2 - Amyloidoses are a heterogeneous group of diverse etiology diseases. They are characterized by an endogenous production of abnormal proteins called amyloid proteins, which are not hydrosoluble, form depots in various organs and tissue of animals and humans and cause dysfunctions. Despite many decades of research, the origin of the pathogenesis and the molecular determinants involved in amyloid diseases has remained elusive. At present, there is not an effective treatment to prevent protein misfolding in these amyloid diseases. The aim of this book is to present an overview of different aspects of amyloidoses from basic mechanisms and diagnosis to latest advancements in treatment. BT - Amyloidosis SP - Ch. 9 UR - https://doi.org/10.5772/20841 DO - 10.5772/20841 SN - PB - IntechOpen CY - Rijeka Y2 - 2024-05-10 ER -