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Nair and Jinu George",authors:[null]},{id:"12160",title:"Properties and Function of Pyomelanin",slug:"properties-and-function-of-pyomelanin",signatures:"C.E. Turick, A.S. Knox, J.M. Becnel, A.A. Ekechukwu and C.E. Milliken",authors:[null]},{id:"12161",title:"Microbial Biopolimerization Production from Palm Oil Mill Effluent (POME)",slug:"microbial-biopolimerization-production-from-palm-oil-mill-effluent-pome-",signatures:"Zaini Ujang, Salmiati Salmiati and Mohd Razman Salim",authors:[null]},{id:"12162",title:"Calculation of Relaxation Spectra from Stress Relaxation Measurements",slug:"calculation-of-relaxation-spectra-from-stress-relaxation-measurements",signatures:"Vassilis Kontogiorgos",authors:[null]},{id:"12163",title:"Fluctuations of Stiff Polymers and Cell Mechanics",slug:"fluctuations-of-stiff-polymers-and-cell-mechanics-",signatures:"Jens Glaser and Klaus Kroy",authors:[null]},{id:"12164",title:"Detect Structure Features of Asymmetric and Symmetric CH2 and CH3 Functional Groups and Their Ratio of Biopolymers within Intact Tissue in Complex Plant System Using Synchrotron FTIRM and DRIFT Molecular Spectroscopy",slug:"detect-structure-features-of-asymmetric-and-symmetric-ch2-and-ch3-functional-groups-and-their-ratio-",signatures:"Peiqiang Yu",authors:[null]},{id:"12165",title:"Molecularly Imprinted Polymers (PIMs) in Biomedical Applications",slug:"molecularly-imprinted-polymers-for-biomedical-applications",signatures:"Francesco Puoci, Giuseppe Cirillo, Manuela Curcio, Francesca Iemma, Ortensia Ilaria Parisi, Umile Gianfranco Spizzirri and Nevio Picci",authors:[null]},{id:"12166",title:"Retracted: Hydrogels as Potential Nano-Scale Drug Delivery Systems",slug:"hydrogels-as-potential-drug-delivery-systems",signatures:"Mohammad Reza Saboktakin",authors:[null]},{id:"12167",title:"Biopolymers for Military Use: Opportunities and Environment Implications - a Review",slug:"biopolymers-for-military-use-opportunities-and-environment-implications-a-review",signatures:"Teodora Zecheru",authors:[null]}]}]},onlineFirst:{chapter:{type:"chapter",id:"72000",title:"Production of Hydroxyapatite on the Surface of Ti6Al7Nb Alloy as Compared to Ti6Al4V Alloy",doi:"10.5772/intechopen.92314",slug:"production-of-hydroxyapatite-on-the-surface-of-ti6al7nb-alloy-as-compared-to-ti6al4v-alloy",body:'Titanium alloys are often used for the production of various tools or devices to be implanted into a human body: artificial joints, blood vessel prostheses, dental implants, and so on. Of the most popular titanium alloys in that field are Ti6Al4V (Titanium grade 5) and Ti6Al4V-ELI (Titanium grade 23), which both have relatively low Young moduli, compatible with that of the bone issues, good fatigue strength, and excellent corrosion resistance in physiological environments [1]. A layer containing mainly Titania (TiO2) is formed spontaneously on the surface of Titanium alloys. Not only does this layer protect the alloy against corrosion, but it also favors their integration with living tissues, that is, osseointegration [2].
Other titanium alloys having suitable properties might present both theoretical and applied interest as the novel materials for medical device production. A Niobium-containing Ti6Al7Nb is one of such alloys. The corrosion behavior of Ti6Al7Nb in the simulated body fluid (SBF) was studied by Rajendran et al. and was found comparable or better than that of Ti6Al4V-ELI [3].
While the bioinertness (including corrosion stability) of titanium alloys is high enough, their readiness to osseointegration leaves much to be desired [1]. One of the plausible strategies allowing a considerable improvement in the osseointegration of titanium alloys is the production of a layer of Hyfroxyapatite (HA) [4] on their surface. Being a mineral constituent of the bone tissue, Hydroxyapatite is an ideal binder between the metal and the living body.
In this study, the surface modification aiming at the production of HA on the surface of Ti6Al4V and Ti6Al7Nb was made by using Plasma Electrolyte Oxidation (PEO), which is a simple technique for producing hard and rough coating having numerous micro-pores [5, 6]. Using that technique, the insertion into the coating of such elements as calcium and phosphorous may be performed by just adding them to the electrolyte in a suitable form. A PEO layer may also present a diffusional and sorption barrier to the release of metal ions into physiological liquids, thus improving the bioinertness of the core metal [7]. PEO coatings often have good adhesion to the metal even if the implant geometry is complex such as screw-shaped implants [8, 9]. PEO by itself does not cause the growth of HA crystals, rather a specimen needs an additional hydrothermal treatment (HT) [4].
The aim of this study is to compare the efficacy of the production of HA on the surfaces of Ti6Al4V and Ti6Al7Nb by PEO and the subsequent HT.
Ti6Al4V samples of 40 mm × 20 mm × 1 mm size and Ti6Al7Nb samples of 40 mm × 20 mm × 3 mm size were cut by laser and grounded by 150, 360, 600, and 1000 grid silicon carbide (SiC) papers. The specimens were rinsed in distilled water and acetone in an ultrasonic cleaner for 5 min. The PEO was performed by the 50 Hz sinusoidal AC current in an electrolyte containing 0.25 M calcium acetate and 0.06 M calcium glycerophosphate in distilled water at the current density of 4A/dm2 for 20 min. The PEO process occurred in a water-cooled stainless-steel container serving as the counter electrode, equipped with a mechanical stirrer. After the completion of the PEO process, the specimens were washed in distilled water and dried on air. After that, the specimens were hydrothermally treated in distilled water or in a KOH solution at 200°C in a pressurized reactor for 2 hours. The pressure during the treatment was 13–15 bar.
The surface morphology and elemental composition were characterized by scanning microscope electron (SEM) TESCAN MAIA3 TriglavTM equipped with AZteq Oxford energy dispersive spectroscopy (EDS) analyzer. X-Ray diffraction (XRD) Rigaku, SmartLab X-RAY DIFRACTOMETER using Cu-Kα radiation (λ = 1.54 Å) in the range of 15–65° angles with a step 0.02° was used to characterize the phase components of the substrates and coating. The thickness of the coatings was measured by ElektroPhysik MiniTest 730 thickness gauge based on eddy current principle by an average of 10 measurements. Focused ion beam (FIB) technique FEI Helios NanoLab™ 600 DualBeam was used for the production of cross-sectional area on a specimen to be further characterized by SEM-EDS. Surface roughness of the samples was evaluated with atomic force microscope (AFM) Bruker’s Dimension FastScan with ScanAsystTM using the contact mode.
The corrosion resistance was determined on an IVIUMnSTAT potentiostat by electrochemical polarization methods, namely Linear Polarization Resistance (LPR) and Tafel Slope Extrapolation (TSE) using a three-electrode cell, where an Ag|AgCl electrode served as the reference electrode, and a platinum wire was the counter electrode. All the corrosion tests were performed in Hank’s solution [10] and a simulated saliva solution [11], whose chemical compositions are given in Table 1. The pH of the electrolytes was 7, and the temperature was maintained at 36.5°C.
Hank’s solution [10] | Saliva solution [11] | ||
---|---|---|---|
Composition, g/L | Reagent | Composition, g/L | |
CaCl2∙2H2O | 0.185 | MgCl2·6H2O | 0.059 |
MgSO4 | 0.09767 | KCl | 0.625 |
KCl | 0.4 | KH2PO4 | 0.326 |
KH2PO4 | 0.06 | K2HPO4 | 0.804 |
NaHCO3 | 0.35 | CaCl2·2H2O | 0.166 |
NaCl | 8.0 | C3H8O3 | 2.00 |
Na2HPO4 | 0.04788 | Sodium carboxymethyl cellulose | 10.0 |
Glucose | 1.0 |
Chemical composition of Hank’s and simulated saliva solutions.
The surface of both titanium alloys after the PEO has the typical for that technique microstructure characterized by microscopic pores scattered randomly across the surface. Cracks seen on the surface are more pronounced for Ti6Al4V (Figure 1).
Back scattered electrons SEM images of the sample’s surface after PEO, ×10,000: (a) Ti6Al4V and (b) Ti6Al7Nb.
After the hydrothermal treatment, the surface has changed. If the HT is performed in distilled water at pH = 7, Ti6Al4V surface is characterized by grainy HA crystals on the surface and very small needle-like HA crystals inside the pores (Figure 2a). Unlike that, numerous HA platelets are observed both inside and outside the pores on the surface of Ti6Al7Nb (Figure 2b). If the HT is made at pH = 11, the surface of Ti6Al4V is covered by ununiform plates of significantly larger HA crystals inside and outside the pores (Figure 2c). Ti6Al7Nb surface contains large plates of HA inside the pores and a mixture of grainy and needle-like crystals outside the pores (Figure 2d).
Surface morphologies after hydrothermal treatment, BSE SEM ×10,000; ×30,000 in the inserts: (a) Ti6Al4V pH = 7; (b) Ti6Al7Nb pH = 7; (c) Ti6Al4V pH = 11; and (d) Ti6Al7Nb pH = 11.
After the completion of the PEO + HT treatment, the surface layers were partially ablated by FIB, so that the ‘cross-sectional’ structure could be seen (Figure 3). As is seen in Figure 3, there is an approximately 1 μm porous PEO oxide layer on the surface of the alloys. The oxide layer has partially amorphous and partially fine crystalline structure (region ‘b’ in the image); above that, an approximately 1 μm hydroxyapatite layer (region ‘c’ in the image) consisting of larger crystallites is present. The thicknesses of the oxide and hydroxyapatite layers may vary from one specimen to another, while their structure remains the same.
A typical FIB-ablated cross-sectional structure of the surface: (a) titanium alloy substrate, (b) PEO porous layer, and (c) hydroxyapatite layer.
The elemental compositions of the surfaces obtained by EDS are given in Table 2. The presented chemical composition is the average of three-point mode analysis, and standard deviations are displayed. The stoichiometric Ca/P ratio for hydroxyapatite is 1.67 that was not observed for any specimen, which means that the surfaces always contain mixtures of various calcium phosphates rather than the pure hydroxyapatite.
Ti | Al | Nb or V | O | Ca | P | Ca/P | |
---|---|---|---|---|---|---|---|
Ti6Al4V, PEO | 15.1 ± 0.1 | 1.6 ± 0.0 | 0.6 ± 0.0 | 63.3 ± 0.2 | 8.6 ± 0.0 | 5.7 ± 0.0 | 1.51 |
Ti6Al7Nb, PEO | 10.5 ± 0.5 | 1.2 ± 0.0 | 0.4 ± 0.0 | 58.1 ± 0.6 | 7.5 ± 0.1 | 4.6 ± 0.0 | 1.63 |
Ti6Al4V, HT pH = 7 | 17.7 ± 1.9 | 1.9 ± 0.0 | 3.0 ± 0.2 | 64.8 ± 0.6 | 7.2 ± 0.4 | 4.4 ± 0.2 | 1.64 |
Ti6Al7Nb, HT pH = 7 | 17.9 ± 0.3 | 2.2 ± 0.1 | 0.7 ± 0.1 | 69.8 ± 0.0 | 5.0 ± 0.3 | 4.6 ± 0.1 | 1.09 |
Ti6Al4V, HT pH = 11 | 15.5 ± 4.6 | 1.6 ± 0.7 | 0.4 ± 0.1 | 59.9 ± 7.7 | 11.6 ± 8.5 | 5.8 ± 3.4 | 2.00 |
Ti6Al7Nb, HT pH = 11 | 14.5 ± 3.4 | 2.1 ± 0.6 | 0.6 ± 0.0 | 65.3 ± 5.3 | 6.1 ± 3.7 | 5.1 ± 1.9 | 1.20 |
Elemental composition (at%, EDS) of the surfaces after PEO and hydrothermal treatments.
In order to determine the phase composition of the surfaces, XRD spectra were measured (Figure 4 and Table 3). It can be seen from Figure 4 and Table 3 that for both alloys no detectable amount of HA is present after PEO. Rather, the surfaces are covered by the mixture of rutile and anatase. Additionally, the surface of Ti6Al4V contains a small amount of tricalcium phosphate Ca2(PO4)2, which is not the case for Ti6Al7Nb. After the HT treatment, an HA phase is detected on the surface of both alloys.
XRD spectra acquired from the coatings: (a) Ti-6Al-4 V and (b) Ti-6Al-7Nb.
Treatment | Ti6Al7Nb | Ti6Al4V |
---|---|---|
PEO | TiO2-rutile, anatase Amorphous phase | TiO2-rutile, anatase Ca3(PO4)2 Amorphous phase |
HTT pH = 7 | TiO2-anatase HA | TiO2-rutile, anatase HA |
HTT pH = 11 | TiO2-anatase HA | TiO2-rutile, anatase HA |
Phase composition of coating after PEO and hydrothermal treatments.
The thickness of the coating was determined by two different methods (Table 4), namely by using a thickness gauge and measuring the FIB-ablated cross sections in SEM images. The measurements reveal higher coating thicknesses for Ti6Al4V than Ti6Al7Nb. Ti6Al4V coating shows also larger and more uneven thickness for Ti6Al4V than for Ti6Al7Nb.
Ti alloy | Treatment | Average coating thickness by SEM, μm | Average coating thickness by thickness gauge, μm |
---|---|---|---|
Ti6Al4V | PEO | 6.4 ± 1.2 | 9.4 ± 1.0 |
HTT pH = 7 | 8.5 ± 1.0 | 8.8 ± 1.1 | |
HTT pH = 11 | 7.0 ± 0.9 | 9.5 ± 1.2 | |
Ti6Al7Nb | PEO | 2.8 ± 0.4 | 2.8 ± 0.3 |
HTT pH = 7 | 3.2 ± 0.1 | 2.4 ± 0.2 | |
HTT pH = 11 | 3.0 ± 0.6 | 2.6 ± 0.4 |
Thickness of the coatings on Ti alloys.
3D AFM images of Ti6Al4V and Ti6Al7Nb after PEO and hydrothermal treatments are shown in Figure 5. The area scanned was 5 μm × 5 μm, and three sites were scanned for each specimen. The values of average roughness (Ra) for all the specimens lie in the range of 50–250 nm (Table 5), and for Ti6Al7Nb, they are higher for all the treatments. As is seen from both AFM (Figure 5) and SEM (Figure 2) images, a more developed surface with plate-shaped HA crystals inside the pores and grainy crystals on the surface is formed on Ti6Al7Nb than on Ti6Al4V. The roughness range of 10 nm to 10 μm is favorable for the osseointegration because it is compatible with the sizes of small cells and large biomolecules [12, 13].
3D AFM images: (a) Ti6Al4V after PEO; (b) Ti6Al4V after HTT pH = 7; (c) Ti6Al4V after HTT pH = 11; (d) Ti6Al7Nb after PEO; (e) Ti6Al7Nb after HTT pH = 7; (f) Ti6Al7Nb after HTT pH = 11.
PEO | HT, pH = 7 | HT, pH = 11 | |
---|---|---|---|
Ti6Al4V | 83.1 | 115.7 | 55.4 |
Ti6Al7Nb | 232.7 | 175.3 | 234.7 |
Ra values (nm) for Ti6Al4V and Ti6Al7Nb surfaces after PEO and HT treatments.
For the determination of corrosion parameters of the alloys, polarization curves of the specimens in Hank’s solution and in artificial saliva were measured in the range of ±250 mV with respect to the OCP at the scan rate of 1 mV/s. Additionally, linear polarization measurements (LPRs) were performed in the narrower range of ±10 mV at the scan rate of 0.5 mV/s. The measured values of corrosion current densities and corrosion potentials are given in Table 6. For some cases (these are marked gray in Table 6), it was not possible to measure the corrosion parameters because the systems were too passive.
Ecorr, mV vs. Ag|AgCl | jcorr, A/cm2, LPR | jcorr, A/cm2, Tafel | ||
---|---|---|---|---|
Ti6Al4V, PEO | Hank’s | −293 | 3.76 | 2.31 |
Saliva | −303 | 2.91 | 2.63 | |
Ti6Al7Nb, PEO | Hank’s | −403 | 2.66 | 1.32 |
Saliva | Passive | |||
Ti6Al4V, HT pH = 7 | Hank’s | −151 | 5.16 | 2.83 |
Saliva | −156 | 2.06 | 1.02 | |
Ti6Al7Nb, HT pH = 7 | Hank’s | Passive | ||
Saliva | Passive | |||
Ti6Al4V, HT pH = 11 | Hank’s | −112 | 1.38 | 1.23 |
Saliva | −127 | 2.32 | 1.30 | |
Ti6Al7Nb, HT pH = 11 | Hank’s | Passive | ||
Saliva | Passive |
Corrosion current density and corrosion potentials for Ti6Al4V and Ti6Al7Nb in Hank’s and saliva solutions.
As is seen from Table 6, all the corrosion potentials that could be measured are significantly shifted to more noble values after the hydrothermal treatment, so that the alloy is effectively passivated. No essential difference was observed for the corrosion potential of the two alloys (at least, when those were measurable).
The values of corrosion current densities are scattered in a quite random manner and therefore are less informative. We assume that due to the relatively poor electrical conductivity of both liquids (the WC-CE resistance measured in the cell was ∼10–20 kΩ for Hank’s solution and for the artificial saliva, which is at least by the factor of 1000 higher than for such strong electrolytes as KCl), the precision of the polarization methods was not sufficient.
The morphologies, elemental and phase’s composition, coating thickness, roughness, and corrosion behavior of Ti6Al4V and Ti6Al7Nb alloys after Plasma Electrolytic Oxidation and the subsequent hydrothermal treatment at various pHs were studied and compared. Hydroxyapatite-containing surfaces can be attained by the two-stage procedure, PEO and HTT, for both alloys.
Thicker, finer, and more uniform oxide layers are formed on the surface of Ti6Al4V than on Ti6Al7Nb for the same treatment parameters.
The most developed surface with plate-shaped HA crystals was obtained for Ti6Al7Nb after HTT in distilled water.
The corrosion potentials are significantly shifted to more noble values after the hydrothermal treatment, so that the alloy is effectively passivated. No essential difference was observed between the corrosion potential of the two alloys. It was found that the polarization corrosion measurement is not precise enough for both alloys in Hank’s solution and in the artificial saliva because of the poor conductivity of both liquids.
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I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. 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