\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-authors-included-in-the-highly-cited-researchers-list-for-2020-20210121",title:"IntechOpen Authors Included in the Highly Cited Researchers List for 2020"},{slug:"intechopen-maintains-position-as-the-world-s-largest-oa-book-publisher-20201218",title:"IntechOpen Maintains Position as the World’s Largest OA Book Publisher"},{slug:"all-intechopen-books-available-on-perlego-20201215",title:"All IntechOpen Books Available on Perlego"},{slug:"oiv-awards-recognizes-intechopen-s-editors-20201127",title:"OIV Awards Recognizes IntechOpen's Editors"},{slug:"intechopen-joins-crossref-s-initiative-for-open-abstracts-i4oa-to-boost-the-discovery-of-research-20201005",title:"IntechOpen joins Crossref's Initiative for Open Abstracts (I4OA) to Boost the Discovery of Research"},{slug:"intechopen-hits-milestone-5-000-open-access-books-published-20200908",title:"IntechOpen hits milestone: 5,000 Open Access books published!"},{slug:"intechopen-books-hosted-on-the-mathworks-book-program-20200819",title:"IntechOpen Books Hosted on the MathWorks Book Program"},{slug:"intechopen-s-chapter-awarded-the-guenther-von-pannewitz-preis-2020-20200715",title:"IntechOpen's Chapter Awarded the Günther-von-Pannewitz-Preis 2020"}]},book:{item:{type:"book",id:"2019",leadTitle:null,fullTitle:"Selected Topics on Optical Fiber Technology",title:"Selected Topics on Optical Fiber Technology",subtitle:null,reviewType:"peer-reviewed",abstract:"This book presents a comprehensive account of the recent advances and research in optical fiber technology. 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He received a prestigious award of Malaysian Rising Star 2016 from the Ministry of Higher Education for his contribution to international collaboration.",institutionString:"University of Malaya",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Malaya",institutionURL:null,country:{name:"Malaysia"}}},coeditorTwo:{id:"23804",title:"Dr.",name:"Hamzah",middleName:null,surname:"Arof",slug:"hamzah-arof",fullName:"Hamzah Arof",profilePictureURL:"https://mts.intechopen.com/storage/users/23804/images/5492_n.jpg",biography:"Hamzah Arof received his BSc from Michigan State University, and PhD from the University of Wales. Both degrees were in electrical engineering. His current research interests include signal processing and photonics. 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His research areas include security in wired and wireless networks, intrusion detection systems, secure routing protocols in wireless ad hoc and sensor networks, secure multicast and broadcast communication in next-generation broadband wireless networks, trust- and reputation-based systems, quality of service in multimedia communication in wireless networks and cross-layer optimization-based resource allocation algorithms in next-generation wireless networks, sensor networks, and privacy issues in ubiquitous and pervasive communication, big data analytics, R, Python, Spark, Hadoop and MapReduce programming. Currently, he is active in the fields of applied statistical modelling, data mining and machine learning, data warehousing and multi-dimensional modelling, social media and mobile analytics, Artificial Intelligence, and Deep Learning. He has more than 200 publications in reputed international journals and referred conference proceedings (IEEE Xplore, ACM Digital Library, Springer LNCS etc.), and eight chapters in books published by internationally renowned publishing houses. He has delivered expert talks and keynote lectures at various international conferences and symposia. He is a senior member of ACM, a member of IEEE, and a lifetime member of Indian Society of Technical Education (ISTE). He was also an active member of the security group of IEEE 802.16 standard body and European Telecommunication Standards Institute (ETSI). His biography has been listed in Marquis Who’s Who in the World annually since 2008. He has delivered invited talks at many prestigious international conferences both in India and abroad and has conducted a number of training programs for teachers of Computer Science and Engineering and Data Science at various universities.",institutionString:"Praxis Business School",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"6",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"537",title:"Network Security",slug:"network-security"}],chapters:[{id:"71876",title:"Introductory Chapter: Machine Learning in Misuse and Anomaly Detection",slug:"introductory-chapter-machine-learning-in-misuse-and-anomaly-detection",totalDownloads:286,totalCrossrefCites:0,authors:[{id:"4519",title:"Prof.",name:"Jaydip",surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen"},{id:"320071",title:"Dr.",name:"Sidra",surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab"}]},{id:"64741",title:"A New Cross-Layer FPGA-Based Security Scheme for Wireless Networks",slug:"a-new-cross-layer-fpga-based-security-scheme-for-wireless-networks",totalDownloads:343,totalCrossrefCites:0,authors:[{id:"267173",title:"Dr.",name:"Michael",surname:"Ekonde Sone",slug:"michael-ekonde-sone",fullName:"Michael Ekonde Sone"}]},{id:"67618",title:"Anomaly-Based Intrusion Detection System",slug:"anomaly-based-intrusion-detection-system",totalDownloads:876,totalCrossrefCites:1,authors:[{id:"269941",title:"Mrs.",name:"Jyothsna",surname:"Veeramreddy",slug:"jyothsna-veeramreddy",fullName:"Jyothsna Veeramreddy"},{id:"321710",title:"Dr.",name:"Koneti Munivara",surname:"Prasad",slug:"koneti-munivara-prasad",fullName:"Koneti Munivara Prasad"}]},{id:"69755",title:"Security in Wireless Local Area Networks (WLANs)",slug:"security-in-wireless-local-area-networks-wlans-",totalDownloads:307,totalCrossrefCites:0,authors:[{id:"267784",title:"Dr.",name:"Rajeev",surname:"Singh",slug:"rajeev-singh",fullName:"Rajeev Singh"},{id:"268313",title:"Dr.",name:"Teek Parval",surname:"Sharma",slug:"teek-parval-sharma",fullName:"Teek Parval Sharma"}]},{id:"71146",title:"Analysis of Network Protocols: The Ability of Concealing the Information",slug:"analysis-of-network-protocols-the-ability-of-concealing-the-information",totalDownloads:233,totalCrossrefCites:0,authors:[{id:"297965",title:"Mr.",name:"Anton",surname:"Noskov",slug:"anton-noskov",fullName:"Anton Noskov"}]},{id:"69777",title:"Multifactor Authentication Methods: A Framework for Their Comparison and Selection",slug:"multifactor-authentication-methods-a-framework-for-their-comparison-and-selection",totalDownloads:255,totalCrossrefCites:0,authors:[{id:"269010",title:"Ph.D.",name:"Angelica",surname:"Caro",slug:"angelica-caro",fullName:"Angelica Caro"},{id:"269446",title:"Dr.",name:"Alfonso",surname:"Rodriguez",slug:"alfonso-rodriguez",fullName:"Alfonso Rodriguez"},{id:"269447",title:"M.Sc.",name:"Ignacio",surname:"Velásquez",slug:"ignacio-velasquez",fullName:"Ignacio Velásquez"}]},{id:"64915",title:"Secure Communication Using Cryptography and Covert Channel",slug:"secure-communication-using-cryptography-and-covert-channel",totalDownloads:155,totalCrossrefCites:0,authors:[{id:"267294",title:"Dr.",name:"Tamer",surname:"Fatayer",slug:"tamer-fatayer",fullName:"Tamer Fatayer"}]},{id:"67728",title:"High-Speed Area-Efficient Implementation of AES Algorithm on Reconfigurable Platform",slug:"high-speed-area-efficient-implementation-of-aes-algorithm-on-reconfigurable-platform",totalDownloads:371,totalCrossrefCites:0,authors:[{id:"269944",title:"Mr.",name:"Altaf",surname:"Mulani",slug:"altaf-mulani",fullName:"Altaf Mulani"},{id:"283911",title:"Dr.",name:"Pradeep",surname:"Mane",slug:"pradeep-mane",fullName:"Pradeep Mane"}]},{id:"64945",title:"Hybrid Approaches to Block Cipher",slug:"hybrid-approaches-to-block-cipher",totalDownloads:437,totalCrossrefCites:0,authors:[{id:"268738",title:"Dr.",name:"Roshan",surname:"Chitrakar",slug:"roshan-chitrakar",fullName:"Roshan Chitrakar"},{id:"278441",title:"Mr.",name:"Roshan",surname:"Bhusal",slug:"roshan-bhusal",fullName:"Roshan Bhusal"},{id:"278442",title:null,name:"Prajwol",surname:"Maharjan",slug:"prajwol-maharjan",fullName:"Prajwol Maharjan"}]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"205697",firstName:"Kristina",lastName:"Kardum Cvitan",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/205697/images/5186_n.jpg",email:"kristina.k@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"3412",title:"Theory and Practice of Cryptography and Network Security Protocols and Technologies",subtitle:null,isOpenForSubmission:!1,hash:"edbd5d0f991597aa78defb420d03f547",slug:"theory-and-practice-of-cryptography-and-network-security-protocols-and-technologies",bookSignature:"Jaydip Sen",coverURL:"https://cdn.intechopen.com/books/images_new/3412.jpg",editedByType:"Edited by",editors:[{id:"4519",title:"Prof.",name:"Jaydip",surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2263",title:"Applied Cryptography and Network 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Disk",doi:"10.5772/intechopen.92028",slug:"vortices-in-rotating-and-gravitating-gas-disk-and-in-a-protoplanetary-disk",body:'
Nonlinear equations describing dynamics of 2D vortices are important in the physics of the ocean and the atmosphere, in plasma physics, and in astrophysics. The same type of nonlinear equations describes these vortical structures. In fluid dynamics, Hasegawa-Mima equation is well-known [1].
which describes the nonlinear Rossby waves in the atmosphere [2] and drift nonlinear waves in plasma [3]. Here
The exact solution of the equation, describing a stationary solitary dipole vortex (modon) drifting along the y-axis on rotating shallow water, was obtained in [4]. The same type of solutions later received a large number of similar equations [5, 6, 7, 8, 9, 10].
Nonlinear vortex disturbances of uniformly rotating gravitating gaseous disk were considered in [9]. For short-scale (much smaller than the Jeans wavelength:
IR, submillimeter, and centimeter radiation of protoplanetary disk analyses shows that vortices serve as incubators for the growth of dust particles and formation of planetesimals [11, 12, 13, 14]. The initial stage of growth probably proceeds through the nucleation of submicron-sized dust grains from the primordial nebula, which then forms the monomers of fractal dust aggregates up to ∼1 mm to ∼10 cm for characteristic time of an order of 103 years [15, 16]. The best astrophysical evidence for grain growth to specified sizes is the detection of 3.5 cm dust emission from the face-on disk of radius 225 AU round classical T Tauri star TW Hya [17]. When the planetesimals reached a size of about 1 km, they began to attract other smaller bodies due to their gravity.
In models of protoplanetary disks, gas practically moves on sub-Keplerian speeds. Rigid particles, under the action of a head wind drag, lose the angular momentum and energy. As a result, the ∼10 cm to meter-sized particles drift to the central star for hundreds of years, that is, much less than the lifetime of a disk which makes several millions of years [18, 19].
Long-lived vortical structures in gas disk are a possible way to concentrate the ∼10 cm to meter-sized particles and to grow up them in planetesimal. Similar effect of vortices on the Earth was observed in special laboratories and also in the ocean [20].
In some areas of the stratified protoplanetary disks, the current has a 2D turbulent character. An attractive feature of such hydrodynamic current consists in the fact that in it, through a background of small whirlpools, long-living vortices will spontaneously be formed without requirement of special initial conditions [21, 22, 23]. In laboratory experiments [24, 25], formation of Burgers vortex, which will be considered here, is often observed in 2D turbulent flows. Anticyclonic vortices in a protoplanetary disk merge with each other and amplify, while cyclonic ones are destroyed by a shear flow [26].
In cylindrical system of coordinates (
This is a vortex with a converging stream of substance to its center with gradient
Rotational velocity profiles of Burgers and Rankin vortices.
A typical circumstellar disk is a few hundred AU (astronomical unit, 1 AU = 1.5 1013 cm) in size. It is mainly composed of hydrogen and helium gas. We consider a vortex in such axially symmetrical viscous accretion disk with effective temperature T and gas density
The sound speed in gas is estimated by
where
In a vertical direction, the gas is in hydrostatic balance with a characteristic scale height:
The thickness-to-radius ratio (aspect ratio) is usually ∼ 1/10 and increases slowly with radius, R. The superficial density of the gas in a disk can be estimated as
In “
The dynamic time scale of a disk is
For Keplerian disk, radial momentum equation solution yields to a difference between the speeds of rigid particles and surrounding gas [30]. In a thin gas disk (
At
For a characteristic time
Viscous dissipation and orbital shear limit the sizes of a vortex. Viscous dissipation destroys vortices of sizes less than the viscous scale [32]:
where
The Keplerian shear flow forbids the formation of circular structures with the sizes larger than the shear length scale:
The vortices, whose sizes surpass
In a gas disk, drag force on rigid particles from gas is exposed, which, depending on size of a particle, is expressed either by Stokes or Epstein’s formula (see, e.g., [25]).
Here our main results obtained by investigations of the linear and nonlinear perturbation equations of differentially rotating gravitating gaseous disk in geostrophic and post-geostrophic approximations are presented [35], as well as the results on formation of planetesimals by Burgers vortex in a protoplanetary disk [26].
Consider at first a gravitating pure gas disk of mass density
We will consider isentropic perturbations (S = constant) and therefore enthalpy H(S, P) = H(P),
where
where
Perturbations of the disk in a rotating with angular velocity
The local frame of reference 1.
where the velocity was presented in the form of
and the Poisson equation is
In Eq. (10) we have used the radial equilibrium condition for the disk:
Taking into account Eq. (9), the continuity Eq. (11) can be written as
Taking operator curl on Eq. (10) and then by combining the equation of continuity, after simple transformation, we obtain
The expression in the curly brackets in this equation is a generalized vortencity. The equation shows that for 2D isentropic perturbations, generalized vortencity is conserved along the current lines. So for stationary perturbations, generalized vortencity is an arbitrary function of
In a uniformly rotating (
This approach assumes that Coriolis forces and gravity balance the pressure gradient in the disk.
Then from the equation of motion (17), we get the perturbed geostrophic velocity:
Using the last, Eq. (18) takes the form
In further analysis of this topic, we will introduce the local Cartesian coordinate system (X,Y) such that (Figure 2)
and will explore the vortical perturbations around a point O in a linear approximation.
The stream function
Imagine around a point O function
In this case
Perturbations of density and enthalpy (9) in linear approach are connected by the following formula:
Then Eq. (13) with an accuracy to a constant term will be in the form of
where
If to take the relationship of density perturbations with perturbations of gravitational potential using Poisson equation
instead of Eq. (25), we obtain the equation
where
The order of magnitude of |H/U| can be estimated using the definition
where k is wavenumber of perturbations
where
Limit
By selection of function B, we can explore the stationary vortex solutions of Eqs. (29) and (30).
Let’s take a look at the simplest case of uniformly rotating disk of homogeneous density,
which gives a circularly symmetric solution for relative perturbed density of mass
where
Note that the vortices with positive and negative velocity circulation
To illustrate these results, we will take into account the fact that the Rossby wavenumber usually is of the order of the inverse thickness of the disk. Considering that the size of the vortex a as the disk thickness order, we will get for the Bessel function argument
3D image of relative density perturbations of whirlwind in the range 0≤R/a<1.4 for 2аkR=20.
For long-scale perturbations (33), the Rankin vortex velocity profile is given [27, 28]:
where
In this section, we will get nonlinear perturbation equation, taking into account the inertia term in the equation of motion (10) for homogeneously rotating disk. The cross product of Eq. (10) with ez: ez × Eq. (10), gives
where the first term is geostrophic speed (19) and the second is
Substituting Eq. (35) to Eq. (36) and taking approximation
With the use of Eqs. (19) and (34), we find
where
The continuity equation now takes the form
or, using Eqs. (14), (20), and (21)
Here we have served the terms that are of second order in perturbed amplitude and neglected terms of highest order.
Using the Poisson equation, we get from Eq. (42) the basic nonlinear equation
where
In view of the assessment (28), for short-scale perturbations (
On the limit
Eqs. (45) and (46) have the same structure differing only by their coefficients, and are Hasegawa-Mima type (see Eq. (1)).
In a Cartesian coordinate system (X,Y) (Figure 2), we will look for stationary solutions of Eq. (45) (and (46)) in a small neighborhood of the guiding center O with a radius of
Eq. (46) can be rewritten in the form
or in the form of the Jacobean
where
On basis of Eq. (49)
where F is an arbitrary function. As we are interested in the restricted solutions, then in the limit of large values η, solution U should vanish for arbitrary values x; therefore
We will assume that the function F (51) in the equation is linear not only for large
where k and p are real constants. Soon the sense of splitting the (
Eqs. (53) and (54) have the following stationary solution [9]:
where
For long-scale perturbations
while for small-scale disturbances
From Eqs. (56) and (19), we get the velocity field of a vortex in the form
Moreover, the condition (57) is derived from the requirements of continuity (61) on the circle
The current lines are determined by
Figure 4 shows the current lines of drifting solitary dipole vortex, the appropriate formula (62).
The stream lines of solitary dipole vortex [9].
As shown in Section 3,
In the long-scale limit,
Since equipotentials U = constant, generally speaking, do not coincide with the contours of constant density, it follows that the stream lines ψ = constant do not coincide with the contours of constant density.
Define the contours of constant density of modon. Relative density perturbations in the short-scale range are expressed by the following formula:
The relative perturbed density in long-scale range turns out to be in the form
where
To illustrate, consider a logarithmic model of the disk, describing in equilibrium by the following functions of potential, mass density, and angular velocity:
where
where we used the relation
For illustrations of a perturbed density distribution in dipole vortex (65), we used the following solutions of “dispersion equation” (57): (g,s) = (4.0, 1.52); (4.2, 2.90); (4.5, 6.0); (4.7, 10.0).
The curves in Figure 5 show perturbed density as a function of dimensionless distance R/a from the guiding center O in the short-scale (curves increasing towards the center) and in the long-scale (curves descending towards the center) limit.
Dependence of relative perturbed density from the dimensionless distance R/a in short-scale and long-scale modons.
The density distribution is antisymmetrical to the guiding center. Depending on the choice of the dispersion curve (57) range, there are two types of mass distribution in dipole vortex. One is antisymmetrically located almost round condensation, and one rarefaction (Figure 6) characterizes the first type. The second type is characterized by the two antisymmetrically located condensations and two rarefactions, and second condensation-rarefaction pair has sickle-form (Figure 7). For small values g and s, the short-scale modon is of the second type, with distinctive two condensations (see Figure 8). In the middle part of the dispersion curve, the short-scale and long-scale modons have roughly the same structure. They have one antisymmetrical located prominent pair of condensation-rarefaction and another weak pair of sickle forms. For large values of g and s, the short-scale modon is the first type and has the character of a cyclone-anticyclone couple; the long-scale one is the second type and is characterized by a nearly round and sickle-shaped condensations. In laboratory experiments, the solitary dipole vortices on shallow water, obviously, are the short-scale modons of the first type with the asymmetry between high- and low-pressure centers.
3D image of density distribution in the first type modon.
3D image of density distribution in the second type modon.
“Dispersive curve”—the solution of Eq. (57). In the three ranges of the curve, 3D images described the relative perturbed density of modon in short-scale (lower row) and long-scale (upper row) limits. The blue color indicates condensations, and red color indicates rarefactions.
Let’s estimate the masses of condensations in long-scale modon:
where
Numerical estimations show that the ratio of the masses of condensations in the long-scale modon, depending on values of parameters g and s, varies in the range
Now we will focus our attention on a role of vortices for the formation of planetesimals in a protoplanetary light dusty disk.
Let’s use the local approach, choosing frame of reference, rotating with a disk with angular speed
The local frame of reference 2.
In case when only the gravitation of the central star operates, rotation will be Keplerian with q = 3/2, and for homogeneously rotating disk,
The substance stream in chosen frame of reference, has X component of speed -
In the local approach, the equation stationary isentropic shear flow of dusk viscous substance is described by Navier–Stokes and continuity equations:
where h is specific enthalpy
In the Cartesian coordinate system, the Burgers vortex (2) will be presented in the form
where
Let us study the two-dimensional dynamics of dust rigid particles in a Burgers vortex. We will neglect the influence of rigid particles on dynamics of gas and the interaction of rigid particles among themselves.
As we consider centimeter- to meter-sized particles, then D considerably surpass the mean free path of gas molecules; therefore, the friction of rigid particles with gas will be described by Stokes drag force:
u = (dX/dt, dY/dt) is velocity of a particle, and X and Y are particle coordinates.
In a dimensionless form, the equation of motion of particles in the accepted approach looks like
where
In Eqs. (76) and (77) a characteristic length is accepted: the size of a trunk of a vortex
In the vortex trunk area (
where
With the use of Eqs. (76)–(81), we receive the equations of motion of rigid particles in the field of a vortex trunk:
where
From Eq. (82) it follows that the equilibrium position of rigid particles in a vortex trunk is its center
For establishing the stability of this position of balance, it is necessary to require real parts of eigenvalues of a matrix in Eq. (82) to be zero or negative.
Eigenvalues are complex:
which gives stability condition
Taking into account Eq. (83), Eq. (84) leads to stability criterion
Hence, the unique position of balance for rigid particles in a Burgers vortex is its center where all particles captured by a vortex will gather during the characteristic time:
The mass of the rigid particles captured by a vortex during this time is in the order
which forms a planetesimal.
So far we have considered the behavior of a whirlwind in a disk plane. However the whirlwind of Burgers is in 3D formation. We will discuss now a question on a thickness of a disk in the area where the Burgers vortex is located. For this purpose we will address a z-projection of the Navier–Stokes Eq. (72). Integrating this equation taking into account the formula for speed
where
The question arises whether the disk thickness in area of vortex localization changed. On radius of
is positive if
First let’s pay attention to the nontrivial structure of monopoly and dipole vortices in a rotating and gravitating pure gas disk. Monopole vortices (33) with mass distribution (32) are localized formations and can have positive and negative velocity circulation, and
More interesting are properties of solitary dipole vortex - modon (60), (61) with mass distribution (65) in short-scale and long-scale limits. There exist two types of mass distribution in dipole vortex. Anti-symmetrically located one almost round condensation and one rarefaction (Figure 6) characterizes the first type. The second type is characterized by the anti-symmetrical located two condensations and two rarefactions, and second condensation-rarefaction pair has sickle-form (Figure 7). Circulation of substance in different parts of modon occurs in opposite direction (Figure 4)!
Now it is difficult to judge about a way of evolution of these structures, for example, whether monopole vortices lead to the formation of planets in circumstellar disks, or the formation of stars or clouds in the galactic gas disk? Or, if it could transformed the dipole vortices to well-known double objects, such as double stars, double nuclei in galaxies (as Mrk 266 [36], Figure 10), as well as in giant molecular clouds, or a planet with a companion in circumstellar disk, or not?
The isodense picture of the galaxy Markaryan 266 with two nuclei, rotating in the opposite direction [36].
As for dusty protoplanetary disks, long-lived anticyclonic vortical structures can capture the ∼10 cm to meter-sized particles and grow up them into planetesimals. Let’s estimate an order of magnitudes of time (86), and mass (87) for planetesimal formation by Burgers vortex for a model of a disk of radius 30 AU and mass
Let the maximum rotation speed of a vortex be ∼10 m/s at distance
The condition (85) is carried out with a large supply for protoplanetary disks. The molecular viscosity of gas, estimated by the formula
Taking
Therefore, during an order of ∼106 year, for meter-sized rigid particles, in the vortex trunk the mass amount comparable with mass of Venus accumulates.
Finally, note that the disk in the Burgers vortex localization area is thicker.
Worldwide, childbearing carries a major risk to the life of women [1]. The Millennium Development Goals (MDGs) were the eight international development goals, and the 192 United Nations states and 23 international organizations had agreed to achieve those goals. Reducing maternal mortality by three quarters over 15 years was a specific part of Goal 5 (Improving Maternal Health) of the eight MDGs [2].
The WHO defines maternal mortality as “the death of a woman while pregnant or within 42 days of termination of pregnancy, irrespective of the duration and site of the pregnancy, from any cause related to or aggravated by the pregnancy or its management but not from accidental or incidental causes” [3].
The maternal mortality ratio (MMR) is a key performance indicator for efforts to improve the safety of mothers before, during, and after childbirth per country. It is the annual number of deaths per 100,000 live births from causes related to or aggravated by pregnancy or its management (not accidental or incidental). It is not to be confused by the maternal mortality rate, which is the number of deaths (direct and indirect) in a given period per 100,000 women of reproductive age during the same time period [1, 2, 3].
The regional MMRs for the year 2015 ranged from 11 to 14 for developed regions to 511–652 for sub-Saharan Africa [4].
In a study that estimated the MMR (maternal deaths per 100,000 live births) among Jordanian women aged between 15 and 49 years, there were 76 maternal deaths out of 397,588 live births. The MMR being 19.1. Of these, 43 (56.6%) deaths were caused by hemorrhage, thrombosis, and sepsis [5].
In this same study, avoidable deaths were found in 53.9% of the dead women, 52.6% had substandard care, and 31.5% were poor hospital attenders, having had three or less antenatal visits [5].
Regarding family planning, less than one third of the 76 dead women had ever used any form of contraception [5].
The incidence of venous thromboembolism (VTE) is 1–2 per 1000 pregnancies. In the antenatal period, there is a fivefold higher incidence than nonpregnant women of same age, with deep venous thrombosis (DVT) being more common. In the postnatal period, there is a 20-fold higher incidence, with pulmonary embolism (PE) being more common. Therefore, VTE is considered as one of the leading causes of pregnancy-related deaths [6, 7, 8, 9, 10].
The German physician, anthropologist, pathologist, prehistorian, and “father of modern pathology,” Rudolf Virchow (1821–1902), postulated a triad to explain the pathophysiology of the increased incidence of VTE in pregnancy, as follows [11]:
Compression of Lt iliac vein by Rt iliac artery or ovarian artery, with 90% DVT on left (vs. 55% nonpregnant), and 70% in iliofemoral veins (vs. 9% nonpregnant)
Hypercoagulability
Increased clotting factors V, VII, VIII, X, VWf, and fibrinogen
Increased resistance to protein C
Decreased protein S activity
Increased levels of fibrinolytic inhibitors via decreased tissue plasminogen activators and increased plasminogen activator inhibitors
Acquired antithrombin III deficiency
Endothelial injury
Compression by the uterus (and edema)
Vascular damage during delivery
There are identifiable risk factors in numerous fatal and nonfatal cases of PE in relation to VTE in pregnancy and puerperium. Therefore, there is a need for risk stratification to determine pharmacological thromboprophylaxis [12].
The risk assessment may be conducted in early pregnancy or prepregnancy at antenatal clinics, at admission to hospital for any reason, intrapartum and immediately postpartum [13].
Hypercoagulability or prothrombotic states increase the risk of thrombosis. Pathologies of this kind are found in a large proportion of women who report one or more episodes of hypercoagulability, such as lower limb or pelvic vein thrombosis, especially when these occur without being provoked by other conditions. A significant number of women have a detectable thrombotic abnormality, where the majority would develop VTE that is related to one or more additional prothrombotic risk factors [13].
Following the description of the development of thrombosis in 1856 by Virchow, antithrombin deficiency was described in 1965 by Norwegian hematologist Egeberg [14]. Researchers from the Scripps Research Institute described protein C deficiency in 1981 [15]. Researchers at the University of Oklahoma described protein S deficiency in 1984 [16, 17, 18].
Graham Hughes, British rheumatologist, described antiphospholipid syndrome 1980s after the finding of antibodies that were associated with SLE and thrombosis [19].
In the 1990s, more studies described genetic thrombophilias and resistance to activated protein C. In 1994, researchers from Leiden, the Netherlands, described a mutation that affected factor V, which made it resistant to activated protein C. Being a genetic defect, it was named factor V Leiden mutation, after its place of discovery [20]. This was followed by the discovery of prothrombin gene mutation by the same group. This mutation results in an increase in prothrombin levels, which may result in some thrombotic episodes [21].
Studies of the human genome and minor gene changes are likely to reveal more genetic abnormalities in cases of hereditary thrombosis [16, 17].
Thrombophilia can be congenital or acquired. Congenital thrombophilia refers to hereditary conditions that increase the tendency to develop thrombosis, while acquired thrombophilia arise later in life [22, 23, 24]. The types of thrombophilia are:
Inherited thrombophilias
Factor V Leiden mutation
Prothrombin C 20210 mutation (PTM)
Antithrombin III deficiency
Protein S deficiency
Protein C deficiency
MTHFR mutation (homocysteine)
Acquired thrombophilias - Antiphospholipid syndrome
Anticardiolipin antibodies
Lupus anticoagulant antibodies
Anti β2 glycoprotein 1 antibodies
Thrombophilia is divided into two groups according to risk types:
High risk
Factor V Leiden mutation, homozygous
Prothrombin C 20210 mutation, homozygous
Antithrombin III deficiency
Antiphospholipid syndrome
Low risk
Factor V Leiden mutation, heterozygous
Prothrombin C 20210 mutation, heterozygous
Protein S deficiency
Protein C deficiency
Most thrombophilias have no specific therapy, but when thrombosis is recurrent, long-term prophylactic anticoagulation is necessary [22, 23, 24].
In general, thrombophilia testing is required for women with history of idiopathic or recurrent episodes of VTE, in addition to women with history of thrombophilia in a first-degree relative [25, 26, 27, 28].
The risk factors for VTE are:
Thrombophilia
Parity of three children or more
Major orthopedic surgery
Lower-extremity paralysis due to spinal cord injury
Fracture of the pelvis, hip, or long bones
Multiple trauma
Paraplegia
Medical comorbidities, for example, cancer, heart failure, SLE, nephrotic syndrome, type I diabetes mellitus with nephropathy, sickle cell disease, and drug addiction
Prior VTE
Smoking
Gross varicose veins
Age, if older than 35
Obesity (BMI more than 30)
Multiple pregnancy
Preeclampsia
Cesarean section
Prolonged labor
Mid-cavity-assisted vaginal delivery
Stillbirth
Preterm birth
Postpartum hemorrhage
Hyperemesis and dehydration
Ovarian hyperstimulation syndrome (OHSS)
Immobility, such as hospitalization and during long travel
Oral contraceptives or estrogen treatment for menopause symptoms
Family history of VTE, especially in a first-degree relative
Physical inactivity
Women who are pregnant or have just had a baby are at greater risk of developing a blood clot. The risk is greater in the presence of other factors. A score is given to each risk factor as follows:
Previous VTE (except a single event related to major surgery) = 4
Previous VTE provoked by major surgery = 3
Known high-risk thrombophilia = 3
Medical comorbidities = 3
Obesity BMI ≥ 30 = 1; BMI ≥ 40 = 2
Cesarean section in labor = 2
Any surgical procedure in pregnancy or puerperium except immediate repair of the perineum + = 3
Hyperemesis =3
OHSS (first trimester only) = 4
Any other = 1
Prophylaxis is administered according to the risk assessment’s total score as follows:
≥4 antenatal: prophylaxis from first trimester and puerperium
3 antenatal: prophylaxis from 28 weeks and puerperium
≥2 postnatal: prophylaxis for at least 10 days
There should be a lower postnatal threshold for prophylaxis than antenatally as risk per day is higher and duration of risk is shorter.
Women with antithrombin deficiency are often on long term oral anticoagulants, and extra advice is necessary as follows:
Prophylaxis with a higher dose of low molecular weight heparin (LMWH) antenatally and 6 weeks postpartum or until return to oral therapy
Anti-Xa monitoring (4-h peak levels 0.5–1.0 iu/ml)
Possible antithrombin therapy at start of labor or prior to cesarean section (CS)
Women with previous recurrent VTE need extra advice as follows:
Higher doses of LMWH
If on long-term warfarin or other oral anticoagulants
Counsel about the risks to the fetus
Stop oral therapy, change to LMWH, within 2 weeks of the missed period and before the sixth week of pregnancy
Not on oral anticoagulants: LMWH as soon as pregnancy test is +ve
There are other first trimester risk factors for VTE that include:
Women with hyperemesis should be considered for prophylaxis with LMWH. Discontinue when it resolves
Women with OHSS need prophylaxis with LMWH in the first trimester
In vitro fertilization pregnancy and three other risk factors need prophylaxis, with LMWH starting in the first trimester
Thromboprophylaxis should be interrupted for delivery in the case of any vaginal bleeding or labor, no further LMWH is administered [13].
When regional anesthetic techniques are considered, the following should be implemented:
Avoid for 12 h after the previous prophylactic dose of LMWH
No LMWH for 4 h after spinal or after epidural catheter removal
No catheter removal for 12 h of injection
If on a therapeutic LMWH, it should be avoided for 24 h after the last dose
With regard to prophylaxis in labor and delivery:
Women on antenatal LMWH having an elective CS should receive prophylactic LMWH on the day prior to CS
The morning dose on CS day should be omitted, the operation should take place that morning
The first prophylactic dose of LMWH should be given 4–6 h after vaginal delivery, 6–12 h after CS (if no postpartum hemorrhage or regional anesthesia)
Women with previous VTE and postpartum thromboprophylaxis should receive LMWH or warfarin for at least 6 weeks regardless of mode of delivery
Women that undergo emergency CS should receive cover with LMWH for 10 days. The same applies for elective CS in the presence of additional risk factors
With regard to LMWH:
It is the agent of choice for antenatal and postnatal prophylaxis
For prophylaxis, the doses based on booking or most recent weight
Platelet count needs monitoring only if prior exposure to unfractionated heparin (UFH)
No need for monitoring of anti-Xa levels if LMWH is for prophylaxis
LMWH should be reduced in renal impairment
LMWH is safe in breastfeeding
Unfractionated heparin should be considered in cases of very high risk of thrombosis, and an increased risk of hemorrhage, UFH may be used peripartum, especially if regional anesthetic may be required. If UFH is used, platelet count should be monitored every 2–3 days from days 4–14 or until UFH is stopped [13].
The molecular weight (MW) of natural heparin is 5000–40,000 Daltons. The MWH is less than 8000 Daltons. The half-life of UFH is 1–2 h, whereas LMWH is 4–8 h.
Danaparoid and fondaparinux are used only when heparins cannot be used due to heparin induced thrombocytopenia or a skin allergy and perhaps should be prescribed by a hematologist with expertise in hemostasis in pregnancy. Regional anesthesia is to be avoided because of 24-h half-life [13].
Low-dose aspirin is not recommended for thromboprophylaxis in obstetric patients [13].
Dextran should be avoided antenatally and intrapartum because it is less effective than LMWH, increases the risk of bleeding and anaphylaxis that has been associated with uterine hypertonus, fetal distress, fetal neurological abnormalities, and fetal death [13].
Oral thrombin and Xa inhibitors are non-vitamin K antagonist oral anticoagulants (NOACs) that should be avoided in pregnant women and are not currently recommended in breastfeeding [13].
Warfarin crosses placenta. If used between 6 and 12 weeks, there is a dose-dependent risk of embryopathy, as 5% of fetuses develop nasal bridge hypoplasia, heart defects, vetriculomegaly, agenesis of corpus callosum, and stippled epiphysis. In addition, it is associated with an increased incidence of spontaneous miscarriage, stillbirth, neurological problems, and fetal and maternal hemorrhage. Its use in pregnancy is restricted to women with mechanical heart valves. It is safe in breastfeeding, and may convert from LMWH to warfarin postpartum when risk of hemorrhage is low, 5–7 days after delivery [13].
The suggested daily thromboprophylactic doses for antenatal and postnatal LMWH are weight dependent. For the average weight of 50–90 kg, the doses of enoxaparin, dalteparin and tinzaparin are 20 mg, 2500 and 3500 iu, respectively.
Contraindications to LMWH are the following:
Known bleeding disorder
Previous or current allergic reactions
Active antenatal or postpartum bleeding
High risk of major hemorrhage
Thrombocytopenia <75 × 109/l
Acute stroke in previous 4 weeks
Severe renal or liver disease
Uncontrolled hypertension
Diagnosis of acute VTE requires high index of suspicion. Its symptoms and signs are:
Leg pain and swelling, usually unilateral
Lower abdominal pain
PE: dyspnea, chest pain, hemoptysis and collapse
Low-grade pyrexia and leukocytosis can occur
The symptoms or signs of VTE require objective testing and treatment with LMWH expeditiously. If DVT remains untreated, 20% will develop pulmonary embolism (PE), which, in pregnancy is fatal in 15%, and in 66% of these, death will result within 30 min of the embolic event [13], that is, there are three deaths per 100 DVTs.
The investigations for suspected DVT include compression duplex ultrasound, CBC, coagulation screen, kidney, and liver function tests. D-dimer and thrombophilia screen are not recommended prior to therapy [13].
The following is recommended in the initial anticoagulant treatment of VTE in pregnancy:
Clinically suspected DVT or PE, LMWH immediately until the diagnosis is excluded by objective testing, unless strongly contraindicated
LMWHs are not associated with an increased risk of severe PPH
Lower risk of heparin-induced osteoporosis with LMWH versus UFHs
LMWH titrated against booking or early pregnancy weight. Insufficient evidence for once daily or in two divided doses
No routine peak anti-Xa activity of LMWH except in weight < 50 kg and > 90 kg or with renal impairment or recurrent VTE
Routine platelet count monitoring should not be carried out
Initial management of DVT, leg elevation, and a graduated elastic compression stocking. Mobilization with graduated elastic compression stockings
Temporary IVC filter peripartum for patients with iliac vein VTE to reduce the risk of PE or recurrent PE despite adequate anticoagulation
Therapeutic doses of subcutaneous LMWH for the remainder of pregnancy and for at least 6 weeks postnatally and for at least 3 months of treatment in total
Because of their adverse effects on the fetus, warfarin should not be used for antenatal VTE treatment
With regard to anticoagulation during labor and delivery, the following should apply:
VTE at term: consider IV UFH, more easily manipulated
If on LMWH for maintenance and in early labor, no further heparin
Planned elective CS or induction of labor, discontinue LMWH maintenance 24 h in advance
No regional anesthesia or analgesia for 24 h after therapeutic LMWH dose
No LMWH for 4 h after spinal anesthesia or after epidural catheter removal. No epidural catheter removal within 12 h of the most recent injection
The initial daily therapeutic doses of enoxaparin, dalteparin, and tinzaparin are weight dependent, their initial doses for the average women between 50 and 90 kg are 60 mg twice daily or 90 mg once daily, 6000 iu twice daily or 1200 iu once daily, 175 iu/kg once daily, respectively [13].
For anticoagulated patients undergoing CS, the following is recommended:
If therapeutic doses of LMWH: wound drains (abdominal and rectus sheath) at CS. Skin closure with interrupted sutures for drainage of any hematoma
Women at high risk of hemorrhage, in whom continued heparin is considered essential, manage with IV UFH until the risk factors for hemorrhage resolve
The regimen for the IV UFH is:
Loading dose of 80 u/kg, followed by a continuous IV infusion of 18 u/kg/h
In case of thrombolysis, omit loading dose and infusion starts at 18 u/kg/h
Mandatory APTT 4–6 h after loading dose, 6 h after dose change, then daily when in therapeutic range. The target is 1.5–2.5 X control value
The infusion rate should be adjusted according to the APTT
To monitor heparin therapy in pregnancy, routine measurement of peak anti-Xa activity of LMWH for acute VTE, if body weight is less than 50 and more than 90 kg, in renal impairment or recurrent VTE is required. Postoperative women receiving UFH should have platelet count every 2–3 days until heparin is stopped. Women are taught to self-inject LMWH and to safely dispose needles etc. [13].
In cases of acute PE, CXR, compression duplex ultrasound and ECG should be performed. ECG may show “S1Q3T3” pattern (large S wave in lead I, Q wave in lead III, and inverted T wave in lead III), Rt BBB, M wave V1 and broad S V6, due to acute right heart strain [13].
If DVT is present, no further investigations are required, and treatment should continue [13].
In suspected PE without symptoms and signs of DVT, CT pulmonary angiogram or V/Q lung scan should be performed. If CXR is abnormal with suspicion of PE, CTPA is better than V/Q scan. In cases of normal ventilation with multiple segmental perfusion deficits, the probability of PE is 80%. There is a slightly increased risk of childhood Ca but lower risk of maternal breast Ca than CTPA. The absolute risk is very small in both [13].
Anticoagulation should be continued until PE is definitively excluded [13].
In acute PE, it is recommended that:
Shocked women who are pregnant or in the puerperium are managed individually regarding IV UFH, thrombolytic therapy or thoracotomy and embolectomy
Multidisciplinary involvement of senior physicians, obstetricians, surgeons, and radiologists
IV UFH is preferred in massive PE with cardiovascular compromise
Urgent portable ECG or CTPA within 1 h of presentation. Immediate thrombolysis should be considered
Maternal resuscitation as per immediate life support. Cardiopulmonary resuscitation in a left lateral tilt. Perimortem CS by 5 min if resuscitation is unsuccessful and the pregnancy is more than 20 weeks
LMWH is the agent of choice for antenatal prophylaxis
Score ≥ 4 antenatal: prophylaxis in first trimester and 6 weeks postnatally
Score = 3 antenatal: prophylaxis from 28 weeks and 6 weeks postnatally
Score ≥ 2 postnatal: prophylaxis for a minimum of 10 days
Women on antenatal prophylaxis are for postnatal prophylaxis for 6 weeks
Women with symptoms or signs of VTE should have LMWH until the diagnosis is excluded by objective testing, unless strongly contraindicated
All women should undergo a documented thromboembolic risk profile for VTE before conception and in early pregnancy
The documented thromboembolic risk profile should be repeated if admission to hospital is required or if an intercurrent medical condition does occur
A repetition of the thromboembolic risk profile is required intrapartum and in the immediate postpartum period
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I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. He is an expert in structural, absorptive, catalytic and photocatalytic properties, in structural organization and dynamic features of ionic liquids, in magnetic interactions between paramagnetic centers. The author or co-author of 3 books, over 200 articles and reviews in scientific journals and books. He is an actual member of the International EPR/ESR Society, European Society on Quantum Solar Energy Conversion, Moscow House of Scientists, of the Board of Moscow Physical Society.",institutionString:null,institution:{name:"Semenov Institute of Chemical Physics",country:{name:"Russia"}}},{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62389/images/3413_n.jpg",biography:"Dr. Ali Demir Sezer has a Ph.D. from Pharmaceutical Biotechnology at the Faculty of Pharmacy, University of Marmara (Turkey). He is the member of many Pharmaceutical Associations and acts as a reviewer of scientific journals and European projects under different research areas such as: drug delivery systems, nanotechnology and pharmaceutical biotechnology. Dr. Sezer is the author of many scientific publications in peer-reviewed journals and poster communications. Focus of his research activity is drug delivery, physico-chemical characterization and biological evaluation of biopolymers micro and nanoparticles as modified drug delivery system, and colloidal drug carriers (liposomes, nanoparticles etc.).",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"61051",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"100762",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"St David's Medical Center",country:{name:"United States of America"}}},{id:"107416",title:"Dr.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Texas Cardiac Arrhythmia",country:{name:"United States of America"}}},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/64434/images/2619_n.jpg",biography:"My name is Angkoon Phinyomark. I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). 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