Open access peer-reviewed Edited volume

Understanding Alzheimer's Disease

Alzheimer's dementia (AD) affects 6 million Europeans with 10% of people over age 65 and more than a quarter over 85. Given the steady aging of European societies, dementia and cognitive decline have developed into a major health problem with an enormous socioeconomic impact for patients, their families and caregivers, national health care systems, and society. Without any means to prevent or delay disease onset, the number of people with dementia is predicted to double by 2030 and triple by 2050. There is an urgent need for innovative strategies to increase understanding of pathological events that would translate into the development of successful prevention or, possibly, novel treatment strategies. Progresses in understanding pathological events in AD have been possible by using cell cultures, genetically modified organisms and animal models that lack the complexity of events occurring in humans. We need to overcome this limitation also by using data from humans - for studying pathological pathways in AD in a multidisciplinary setting.

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IntechOpen
Understanding Alzheimer's DiseaseEdited by Inga Zerr

Published: February 27th 2013

DOI: 10.5772/46004

ISBN: 978-953-51-1009-5

chaptersCrossref citationsDownloads

Open access peer-reviewed

1. Structure and Function of the APP Intracellular Domain in Health and Disease

By Ulrike Müller and Klemens Wild

1622

Open access peer-reviewed

2. Mechanism of Alzheimer Amyloid β-Protein Precursor Localization to Membrane Lipid Rafts

By Yuhki Saito, Takahide Matsushima and Toshiharu Suzuki

1315

Open access peer-reviewed

3. The Amyloidogenic Pathway Meets the Reelin Signaling Cascade: A Cytoskeleton Bridge Between Neurodevelopment and Neurodegeneration

By Daniel A. Bórquez, Ismael Palacios and Christian González-Billault

1069

Open access peer-reviewed

4. γ-Secretase — Regulated Signaling and Alzheimer's Disease

By Kohzo Nakayama, Hisashi Nagase, Chang-Sung Koh and Takeshi Ohkawara

1506

Open access peer-reviewed

5. Phosphorylation of Tau Protein Associated as a Protective Mechanism in the Presence of Toxic, C-Terminally Truncated Tau in Alzheimer's Disease

By José Luna-Muñoz, Charles R. Harrington, Claude M. Wischik, Paola Flores-Rodríguez, Jesús Avila, Sergio R. Zamudio, Fidel De la Cruz, Raúl Mena, Marco A. Meraz-Ríos and Benjamin Floran-Garduño

33638

Open access peer-reviewed

6. Pin1 Protects Against Alzheimer's Disease: One Goal, Multiple Mechanisms

By Lucia Pastorino, Asami Kondo, Xiao Zhen Zhou and Kun Ping Lu

1451

Open access peer-reviewed

7. Alzheimer Disease and Metabolism: Role of Cholesterol and Membrane Fluidity

By Genaro G. Ortiz, Fermín P. Pacheco-Moisés, Luis J. Flores-Alvarado, Miguel A. Macías-Islas, Irma E. Velázquez-Brizuela, Ana C. Ramírez- Anguiano, Erandis D. Tórres-Sánchez, Eddic W. Moráles-Sánchez, José A. Cruz-Ramos, Genaro E Ortiz-Velázquez and Fernando Cortés-Enríquez

1680

Open access peer-reviewed

8. Pre-Analytical and Analytical Critical Factors Influencing the High Variability of the Concentrations Levels of Alzheimer Disease Biomarkers in Cerebral Spinal Fluid

By Armand Perret-Liaudet, Aline Dorey, Yannick Tholance, Benoit Dumont and Isabelle Quadrio

11189

Open access peer-reviewed

9. Candidate Bio-Markers of Alzheimer’s Disease

By B.K. Binukumar and Harish C. Pant

1839

Open access peer-reviewed

10. Using Magnetic Resonance Imaging in the Early Detection of Alzheimer's Disease

By Emily J. Mason, Manus J. Donahue and Brandon A. Ally

1390

Open access peer-reviewed

11. Potential Therapeutic Strategies to Prevent the Progression of Alzheimer to Disease States

By Ester Aso and Isidre Ferrer

12027

Open access peer-reviewed

12. Animal Assisted Therapy and Activities in Alzheimer's Disease

By Sibel Cevizci, Halil Murat Sen, Fahri Güneş and Elif Karaahmet

2642

Open access peer-reviewed

13. Epidemiology of Alzheimer’s Disease

By Weili Xu, Camilla Ferrari and Hui-Xin Wang

1783

Open access peer-reviewed

14. Apathy as a Key Symptom in Behavior Disorders: Difference Between Alzheimer’s Disease and Subcortical Vascular Dementia

By Rita Moretti, Paola Torre, Francesca Esposito, Enrica Barro, Paola Tomietto and Rodolfo M. Antonello

21450

Open access peer-reviewed

15. Predicting Cognitive Decline in Alzheimer’s Disease (AD): The Role of Clinical, Cognitive Characteristics and Biomarkers

By Mei Sian Chong and Tih-Shih Lee

1397

Open access peer-reviewed

16. Alzheimer’s Disease and Diabetes

By Brent D. Aulston, Gary L. Odero, Zaid Aboud and Gordon W. Glazner

1677

Open access peer-reviewed

17. Prevention of Alzheimer’s Disease: Intervention Studies

By Francesca Mangialasche, Weili Xu and Miia Kivipelto

1789

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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20Web of Science citations

8Crossref citations

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