Open access peer-reviewed Edited Volume

Tyrosine Kinases as Druggable Targets in Cancer

Edited by Huan Ren

Harbin Medical University

Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment.

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Tyrosine Kinases as Druggable Targets in CancerEdited by Huan Ren

Published: September 25th 2019

DOI: 10.5772/intechopen.79884

ISBN: 978-1-78984-809-0

Print ISBN: 978-1-78984-808-3

eBook (PDF) ISBN: 978-1-83962-219-9

Copyright year: 2019

Books open for chapter submissions

773 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: Tyrosine Kinases as Drug Targets in Cancer Treatment

By Huan Ren

27

Open access peer-reviewed

2. Non-receptor Tyrosine Kinases Role and Significance in Hematological Malignancies

By Ana Azevedo, Susana Silva and José Rueff

143

Open access peer-reviewed

3. JAK, an Oncokinase in Hematological Cancer

By Carlota Recio, Haidée Aranda-Tavío, Miguel Guerra-Rodríguez, Mercedes de Mirecki-Garrido, Patricia Martín-Rodríguez, Borja Guerra and Leandro Fernández-Pérez

159

Open access peer-reviewed

4. Noncoding RNAs as Predictive Biomarkers of Therapeutic Response to Tyrosine Kinase Inhibitors in Metastatic Cancer

By Julia Kovacova and Ondrej Slaby

90

Open access peer-reviewed

5. Cancer Management by Tyrosine Kinase Inhibitors: Efficacy, Limitation, and Future Strategies

By Venice Wing Tung Ho, Hor Yue Tan, Ning Wang and Yibin Feng

362

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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