Open access peer-reviewed Edited Volume

Treatment of Metastatic Melanoma

Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, and adjuvant radiotherapy to regional lymph node fields following surgical resection reduces loco-regional recurrence in patients at high risk of relapse. Isolated limb perfusion, electrochemotherapy, and photodynamic therapy continue to be evaluated for treatment of stage IV disease. However, the greatest excitement in new treatment has been with targeted therapies for genetic mutations. In particular, the promising results of partial and complete tumor response in stage IV disease from early phase trials of the B-RAF kinase inhibitors. This book provides a contemporary insight into the therapeutic treatment options for patients with metastatic melanoma and is relevant to clinicians and researchers worldwide. In addition, an update on current clinical trials for melanoma treatment has been included, and two chapters have been reserved to discuss the treatment of oral and uveal melanoma.

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Treatment of Metastatic MelanomaEdited by Rachael Morton

Published: October 5th 2011

DOI: 10.5772/1034

ISBN: 978-953-307-574-7

eBook (PDF) ISBN: 978-953-51-6513-2

Copyright year: 2011

Books open for chapter submissions

45766 Total Chapter Downloads

3 Crossref Citations

19 Web of Science Citations

23 Dimensions Citations


Open access peer-reviewed

1. Cutaneous Metastases from Malignant Melanoma: Clinical Features and New Therapeutic Perspectives

By Paola Savoia, Paolo Fava and Maria Grazia Bernengo


Open access peer-reviewed

2. Impact of Sentinel Node Biopsy on Outcome in Melanoma

By Justin Kelly and MJ Kerin


Open access peer-reviewed

3. Management of Head and Neck Melanoma

By James H F Shaw and Michael Fay


Open access peer-reviewed

4. Diagnosis and Treatment Options for Brain Metastasis of Melanoma

By Khan K. Chaichana and Kaisorn L. Chaichana


Open access peer-reviewed

5. Chemotherapy

By Aylin Türel Ermertcan, Ferdi Öztürk and Kamer Gündüz


Open access peer-reviewed

6. Chemocentric Chemoimmunotherapy: A New Concept in Melanoma Immunotherapy

By Paul Howell, Soroosh Radfar, Yixiang Wang and Hung Khong


Open access peer-reviewed

7. Melanoma Immunomodulation: A War of Attrition

By Bently P. Doonan, Jessica D. Hathaway and Azizul Haque


Open access peer-reviewed

8. Simultaneous Knockdown of Mutant BRAF and Expression of INK4A in Melanoma Cells Leads to Potent Growth Inhibition and Apoptosis

By Jianli Dong and Chet L. Schwab


Open access peer-reviewed

9. Promising Experimental Therapies for Metastatic Melanoma

By Bao Lam, Patrick A. Ott and Anna C. Pavlick


Open access peer-reviewed

10. The Role of Electrochemotherapy in the Treatment of Malignant Melanoma

By Mecker G. Möller, Slawomir Salwa, Declan M. Soden and Gerald C. O’Sullivan


Open access peer-reviewed

11. Pulse Power Ablation of Melanoma with Nanosecond Pulsed Electric Fields

By Stephen J. Beebe, Wentia E. Ford, Wei Ren and Xinhua Chen


Open access peer-reviewed

12. Can Photodynamic Therapy Be an Alternative Method in Melanoma Treatment?

By Anna Choromańska, Julita Kulbacka, Agnieszka Chwiłkowska, Nina Skołucka, Andrzej Gamian and Jolanta Saczko


Open access peer-reviewed

13. Update on Clinical Trials for Malignant Melanoma

By Raffaele Califano, Ruth Board, Aidalena Z Abidin, Louise Carter, Laura Cove-Smith, Bihani Kularatne and Paul Lorigan


Open access peer-reviewed

14. Oral Malignant Melanoma

By Thomas Mücke, Anna Borgmann, Klaus-Dietrich Wolff and David Andrew Mitchell


Open access peer-reviewed

15. Choroidal Melanoma

By Raquel Correa, Mario Lobato and José Antonio Medina


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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