Open access peer-reviewed Edited volume

Treatment of Metastatic Melanoma

Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, and adjuvant radiotherapy to regional lymph node fields following surgical resection reduces loco-regional recurrence in patients at high risk of relapse. Isolated limb perfusion, electrochemotherapy, and photodynamic therapy continue to be evaluated for treatment of stage IV disease. However, the greatest excitement in new treatment has been with targeted therapies for genetic mutations. In particular, the promising results of partial and complete tumor response in stage IV disease from early phase trials of the B-RAF kinase inhibitors. This book provides a contemporary insight into the therapeutic treatment options for patients with metastatic melanoma and is relevant to clinicians and researchers worldwide. In addition, an update on current clinical trials for melanoma treatment has been included, and two chapters have been reserved to discuss the treatment of oral and uveal melanoma.

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Treatment of Metastatic MelanomaEdited by Rachael Morton

Published: October 5th 2011

DOI: 10.5772/1034

ISBN: 978-953-307-574-7

Books open for chapter submissions

37469 Total Chapter Downloads

1 Crossref Citations

9 Web of Science Citations

14 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Cutaneous Metastases from Malignant Melanoma: Clinical Features and New Therapeutic Perspectives

By Paola Savoia, Paolo Fava and Maria Grazia Bernengo

5306

Open access peer-reviewed

2. Impact of Sentinel Node Biopsy on Outcome in Melanoma

By Justin Kelly and MJ Kerin

1924

Open access peer-reviewed

3. Management of Head and Neck Melanoma

By James H F Shaw and Michael Fay

1342

Open access peer-reviewed

4. Diagnosis and Treatment Options for Brain Metastasis of Melanoma

By Khan K. Chaichana and Kaisorn L. Chaichana

10009

Open access peer-reviewed

5. Chemotherapy

By Aylin Türel Ermertcan, Ferdi Öztürk and Kamer Gündüz

702

Open access peer-reviewed

6. Chemocentric Chemoimmunotherapy: A New Concept in Melanoma Immunotherapy

By Paul Howell, Soroosh Radfar, Yixiang Wang and Hung Khong

1070

Open access peer-reviewed

7. Melanoma Immunomodulation: A War of Attrition

By Bently P. Doonan, Jessica D. Hathaway and Azizul Haque

1168

Open access peer-reviewed

8. Simultaneous Knockdown of Mutant BRAF and Expression of INK4A in Melanoma Cells Leads to Potent Growth Inhibition and Apoptosis

By Jianli Dong and Chet L. Schwab

1587

Open access peer-reviewed

9. Promising Experimental Therapies for Metastatic Melanoma

By Bao Lam, Patrick A. Ott and Anna C. Pavlick

1075

Open access peer-reviewed

10. The Role of Electrochemotherapy in the Treatment of Malignant Melanoma

By Mecker G. Möller, Slawomir Salwa, Declan M. Soden and Gerald C. O’Sullivan

2110

Open access peer-reviewed

11. Pulse Power Ablation of Melanoma with Nanosecond Pulsed Electric Fields

By Stephen J. Beebe, Wentia E. Ford, Wei Ren and Xinhua Chen

1679

Open access peer-reviewed

12. Can Photodynamic Therapy Be an Alternative Method in Melanoma Treatment?

By Anna Choromańska, Julita Kulbacka, Agnieszka Chwiłkowska, Nina Skołucka, Andrzej Gamian and Jolanta Saczko

1837

Open access peer-reviewed

13. Update on Clinical Trials for Malignant Melanoma

By Raffaele Califano, Ruth Board, Aidalena Z Abidin, Louise Carter, Laura Cove-Smith, Bihani Kularatne and Paul Lorigan

1493

Open access peer-reviewed

14. Oral Malignant Melanoma

By Thomas Mücke, Anna Borgmann, Klaus-Dietrich Wolff and David Andrew Mitchell

4839

Open access peer-reviewed

15. Choroidal Melanoma

By Raquel Correa, Mario Lobato and José Antonio Medina

1328

Edited volume and chapters are indexed in

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  • Google Scholar
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  • Base
  • CNKI

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