Open access peer-reviewed Edited Volume

Traumatic Brain Injury

Neurobiology, Diagnosis and Treatment

Edited by Yongxia Zhou

University of Southern California

Traumatic brain injury (TBI) is a significant public health problem. There are several advanced techniques available for the investigation of disease neurobiology, diagnosis, and treatment. This book covers many topics in the active TBI research field such as cumulative mild head injury review, brain changes, and risk factors, as well as post-concussion syndrome (PCS) definition, classification, and association with brain dysfunction. Brain changes, including blood flow, intracranial pressure, and neuroinflammation, the neurobiological basis of neuroprotective activation, as well as correlation with PCS, including sleep, are illustrated further. Furthermore, multiple biomarkers, including S-100?, UCH-L1, and GFAP for blood-brain barrier breakdown and neuronal injury, are reviewed thoroughly. Lastly, well-evaluated neuroprotective agents, hypothermia as a neuroprotective effect in TBI, and effects investigation, as well as sedation in TBI as a neurocritical and therapeutic strategy with different assessments, are reported. This book introduces readers to a number of perspectives, including TBI disease pathophysiology and post-concussion syndrome classification, associated brain changes, imaging diagnosis, and several useful biomarkers with high sensitivities, as well as multiple therapeutic strategies. Various advanced technical developments, upfront neuroimaging, and clinical data are presented together with comprehensive, up-to-date, and interesting examples. Detailed reviews and accurate illustrations together with objective and informative discussions of several challenging problems such as PCS and neuroprotective treatments are the advantages of this book. Finally, this book will hopefully convey the clinical aspects of TBI and help guide diagnosis and therapeutic research in this field.

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Traumatic Brain InjuryNeurobiology, Diagnosis and TreatmentEdited by Yongxia Zhou

Published: September 11th 2019

DOI: 10.5772/intechopen.77680

ISBN: 978-1-78984-296-8

Print ISBN: 978-1-78984-295-1

eBook (PDF) ISBN: 978-1-78984-500-6

Copyright year: 2019

Books open for chapter submissions

3683 Total Chapter Downloads

2 Dimensions Citations


Open access peer-reviewed

1. Post Concussion Syndrome

By Mohammad Nadir Haider and Itai Bezherano


Open access peer-reviewed

2. Neuroprotection, Photoperiod, and Sleep

By Marina Martinez-Vargas, Mercedes Graciela Porras-Villalobos, Francisco Estrada-Rojo, Ricardo Jesus Martinez-Tapia, Adan Perez-Arredondo, Antonio Barajas-Martinez and Luz Navarro


Open access peer-reviewed

3. Cumulative Mild Head Injury (CMHI) in Contact Sports

By Kathryn Nel and Saraswathie Govender


Open access peer-reviewed

4. Neuronal and Glial Biomarkers Research for Traumatic Brain Injury

By Alexander Rodríguez, Eliana Cervera and Pedro Villalba


Open access peer-reviewed

5. Use of Neuroprotective agents for Traumatic Brain Injury

By Mohammad Meshkini, Ali Meshkini and Homayoun Sadeghi-Bazargani


Open access peer-reviewed

6. Direct Brain Cooling in Treating Severe Traumatic Head Injury

By Zamzuri Idris, Ang Song Yee, Regunath Kandasamy, Asrulnizam Abd Manaf, Mohd Hasyizan Bin Hassan and Wan Nazaruddin Wan Hassan


Open access peer-reviewed

7. Sedation in TBI Patients

By Lorenzo Peluso, Berta Monleon Lopez and Rafael Badenes


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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