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Prediction of Partition Coefficients and Permeability of Drug Molecules in Biological Systems with Abraham Model Solute Descriptors Derived from Measured Solubilities and Water-to-Organic Solvent Partition Coefficients

By William E. Acree, Jr., Laura M. Grubbs and Michael H. Abraham

Submitted: November 1st 2010Reviewed: December 17th 2010Published: February 10th 2012

DOI: 10.5772/19082

Downloaded: 8315

© 2012 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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William E. Acree, Jr., Laura M. Grubbs and Michael H. Abraham (February 10th 2012). Prediction of Partition Coefficients and Permeability of Drug Molecules in Biological Systems with Abraham Model Solute Descriptors Derived from Measured Solubilities and Water-to-Organic Solvent Partition Coefficients, Toxicity and Drug Testing William Acree, IntechOpen, DOI: 10.5772/19082. Available from:

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