Open access peer-reviewed Edited Volume

Towards New Therapies for Parkinson's Disease

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

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Towards New Therapies for Parkinson's DiseaseEdited by David Finkelstein

Published: November 2nd 2011

DOI: 10.5772/954

ISBN: 978-953-307-463-4

eBook (PDF) ISBN: 978-953-51-6545-3

Copyright year: 2011

Books open for chapter submissions

33847 Total Chapter Downloads

8 Crossref Citations

18 Web of Science Citations

23 Dimensions Citations


Open access peer-reviewed

1. Controversial Issues in Deep Brain Stimulation in Parkinson's Disease

By Shin-Yuan Chen, Sheng-Tzung Tsai and Sheng-Huang Lin


Open access peer-reviewed

2. Cost and Efficacy of Therapies for Advanced Parkinson's Disease

By Francesc Valldeoriola


Open access peer-reviewed

3. Botulinum A Toxin Intravesical Injections in the Treatment of Refractory Overactive Bladder in Patients with Parkinson's Disease

By Antonella Giannantoni, Silvia Proietti, Antonella Conte, Massimo Porena and Alfredo Berardelli


Open access peer-reviewed

4. Alpha-Synuclein and the Immune Response in Parkinson’s Disease

By Cintia Roodveldt, Adahir Labrador-Garrido, Guillermo Izquierdo and David Pozo


Open access peer-reviewed

5. The Knoll-Concept to Decrease the Prevalence of Parkinson’s Disease

By Ildikó Miklya


Open access peer-reviewed

6. Utility of Organotypic Slices in Parkinson's Disease Research

By Fabio Cavaliere and Carlos Matute


Open access peer-reviewed

7. Therapeutic Potential of Polyphenols in Parkinson’s Disease

By Rajeswara Babu Mythri, G. Harish, N. Raghunath and M.M. Srinivas Bharath


Open access peer-reviewed

8. Inhibition of Tau Phosphorylation as a Potential Strategy in Treatment of Parkinson’s Disease

By Wang Wenya


Open access peer-reviewed

9. The Protective Effects of Pre-Treatment with Glutamate Metabotropic Receptor Agonists on the Development of Parkinsonian Movements

By Munir Qazzaz, Rateb M. Husein, Munther Metani and Abdul-Salam Abdul-Ghani


Open access peer-reviewed

10. GDNF and PD: Less Common Points of View

By Ana Saavedra and Graça Baltazar


Open access peer-reviewed

11. The Potential of Neurotrophic Factors for the Treatment of Parkinson’s Disease

By Aideen M. Sullivan and André Toulouse


Open access peer-reviewed

12. Gene Therapy for Parkinson’s Disease

By Michael Douglas and Jonathan Hazlehurst


Open access peer-reviewed

13. Gene Therapy for Parkinson’s Disease: Towards Non Invasive Approaches

By Manuel Rodríguez, José M. Brito-Armas and Rafael Castro


Open access peer-reviewed

14. Epigenetic Modulation of Adenosine A2A Receptor: A Putative Therapeutical Tool for the Treatment of Parkinson’s Disease

By Marta Barrachina, Mairena Martín, Francisco Ciruela and Isidre Ferrer


Open access peer-reviewed

15. 1980-2011: Parkinson's Disease and Advance in Stem Cell Research

By Lidia Cova and Marie-Therese Armentero


Open access peer-reviewed

16. Cell Therapy for Parkinson’s Disease: Status and Perspectives

By Pia Jensen, Christina Krabbe and Morten Meyer


Open access peer-reviewed

17. Transplantation of Foetal Ventral Mesencephalic Grafts in Parkinson’s Disease: A Still Evolving Concept with New Regulatory Challenges

By Sven Möllers, Máté Döbrössy and Guido Nikkhah


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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