Open access peer-reviewed Edited Volume

Systemic Sclerosis

An Update on the Aberrant Immune System and Clinical Features

Edited by Timothy Radstake

Radboud University Nijmegen, Netherlands

Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has yet to be determined: endothelial dysfunction, autoantibody formation, and activation of fibroblasts. This current book provides up-to-date information on the pathogenesis and clinical features of this severe syndrome. It is our hope that this book will aid both clinicians and researchers in dealing with patients with this clinical syndrome. In addition, we hope to shed more light on this rare and severely disabling syndrome, ultimately leading to better research and successful therapeutic targeting.

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Systemic SclerosisAn Update on the Aberrant Immune System and Clinical FeaturesEdited by Timothy Radstake

Published: February 3rd 2012

DOI: 10.5772/1326

ISBN: 978-953-307-869-4

Copyright year: 2012

Books open for chapter submissions

21419 Total Chapter Downloads

1 Crossref Citations

1 Web of Science Citations

5 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Pathogenesis of the Endothelial Damage and Related Factors

By Paola Cipriani, Vasiliki Liakouli, Alessandra Marrelli, Roberto Perricone and Roberto Giacomelli

1397

Open access peer-reviewed

2. Blood Platelets and Systemic Sclerosis

By Sébastien Lepreux, Anne Solanilla, Julien Villeneuve, Joël Constans, Alexis Desmoulière and Jean Ripoche

1658

Open access peer-reviewed

3. Using Proteomic Analysis for Studying the Skin Fibroblast Protein Profile in Systemic Sclerosis

By P. Coral-Alvarado, G. Quintana, C. Cardozo, J. Iriarte, Y. Sanchez, S. Bravo, J. Castano, M.F. Garces, L. Cepeda, A. Iglesias-Gamarra and J.E. Caminos

1514

Open access peer-reviewed

4. Apoptosis of T Lymphocytes in Systemic Sclerosis

By M. Szymanek, G. Chodorowska, A. Pietrzak and D. Krasowska

1208

Open access peer-reviewed

5. Cytokines in Systemic Sclerosis: Focus on IL-17

By Julie Baraut, Dominique Farge, Elena Ivan-Grigore, Franck Verrecchia and Laurence Michel

1995

Open access peer-reviewed

6. Biological Ageing Research in Systemic Sclerosis: Time to Grow up?

By J.C.A. Broen, L. McGlynn, T.R.D.J. Radstake and P.G. Shiels

1178

Open access peer-reviewed

7. Fibrocytes in Scleroderma Lung Fibrosis

By Ronald Reilkoff, Aditi Mathur and Erica Herzog

1846

Open access peer-reviewed

8. Inhibition of Thrombin as a Novel Strategy in the Treatment of Scleroderma-Associated Interstitial Lung Disease

By Galina S. Bogatkevich, Kristin B. Highland, Tanjina Akter, Paul J. Nietert, Ilia Atanelishvili, Joanne van Ryn and Richard M. Silver

1416

Open access peer-reviewed

9. Emerging Issues in the Immunopathogenesis, Diagnosis and Clinical Management of Primary Biliary Cirrhosis Associated with Systemic Sclerosis

By Dimitrios P. Bogdanos, Cristina Rigamonti, Daniel Smyk, Maria G. Mytilinaiou, Eirini I. Rigopoulou and Andrew K. Burroughs

1299

Open access peer-reviewed

10. Capillary Dimension Measured by Computer Based Digitalized Image in Patients with Systemic Sclerosis

By Hyun-Sook Kim

1428

Open access peer-reviewed

11. Scleroderma Renal Crisis

By Lola Chabtini, Marwan Mounayar, Jamil Azzi, Vanesa Bijol, Sheldon Bastacky, Helmut G Rennke and Ibrahim Batal

4099

Open access peer-reviewed

12. Pregnancy and Scleroderma

By Charlotte Gorgiard, Alice Bérezné and Luc Mouthon

2381

Edited Volume and chapters are indexed in

  • Worldcat
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  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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