Open access peer-reviewed Edited Volume

Synucleins

Biochemistry and Role in Diseases

Edited by Andrei Surguchov

Kansas University Medical Center

Neurodegenerative diseases are debilitating conditions that result in degeneration and death of nerve cells. A significant group of these diseases is the synucleinopathies, which are characterized by the accumulation of aggregates of alpha-synuclein in neurons, nerve fibers, or glial cells. There are three main types of synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Synucleins are small, naturally unfolded proteins prone to aggregate and form intracellular inclusions, which impair normal cellular functions. This book presents new data on synuclein aggregation and its effect on cholesterol transport. It also discusses the role of genetic contribution to these diseases and approaches to inhibition of synuclein aggregation.

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SynucleinsBiochemistry and Role in DiseasesEdited by Andrei Surguchov

Published: April 8th 2020

DOI: 10.5772/intechopen.73750

ISBN: 978-1-78984-588-4

Print ISBN: 978-1-78984-565-5

eBook (PDF) ISBN: 978-1-78984-589-1

Copyright year: 2020

Books open for chapter submissions

1399 Total Chapter Downloads

3 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: Little Pigeons Can Carry Great Messages

By Andrei Surguchov

217

Open access peer-reviewed

2. Alpha-Synuclein Aggregation, Cholesterol Transport, and the 18-kDa Translocator Protein

By Jasmina Dimitrova-Shumkovska and Ljupcho Krstanoski

117

Open access peer-reviewed

3. The Relationship between Alpha-Synuclein (SNCA) Gene Polymorphisms and Development Risk of Parkinson’s Disease

By Nevra Alkanli and Arzu Ay

351

Open access peer-reviewed

4. Therapeutic Potential of Baicalein in Parkinson’s Disease: Focus on Inhibition of α-Synuclein Oligomerization and Aggregation

By Hayate Javed and Shreesh Ojha

388

Open access peer-reviewed

5. Role of Phenylalanine and Its Metabolites in Health and Neurological Disorders

By Muhammad Akram, Muhammad Daniyal, Aatiqa Ali, Rida Zainab, Syed Muhammad Ali Shah, Naveed Munir and Imtiaz Mahmood Tahir

47

Open access peer-reviewed

6. Role of Osmolytes in Amyloidosis

By Sheeza Khan, Zeba Mueed, Ravi Deval, Pankaj Kumar Rai, Dinesh Kumar Prajapati and Nitesh Kumar Poddar

287

Edited Volume and chapters are indexed in

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  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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