Open access peer-reviewed Edited Volume

Stromal Cells

Structure, Function, and Therapeutic Implications

Edited by Mani T. Valarmathi

The University of Alabama at Birmingham

Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.

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Stromal CellsStructure, Function, and Therapeutic ImplicationsEdited by Mani T. Valarmathi

Published: January 23rd 2019

DOI: 10.5772/intechopen.71899

ISBN: 978-1-78984-985-1

Print ISBN: 978-1-78984-984-4

eBook (PDF) ISBN: 978-1-83881-624-7

Copyright year: 2019

Books open for chapter submissions

7360 Total Chapter Downloads

9 Crossref Citations

6 Web of Science Citations

18 Dimensions Citations


Open access peer-reviewed

1. Stromal Stem Cells: Nature, Biology and Potential Therapeutic Applications

By Amira Hassouna, Marwa M. Abd Elgwad and Hoda Fahmy


Open access peer-reviewed

2. Stromal Cell Ultrastructure

By Amany A. Moneim Solaiman


Open access peer-reviewed

3. Adult Stem Cell Membrane Markers: Their Importance and Critical Role in Their Proliferation and Differentiation Potentials

By Maria Teresa Gonzalez Garza


Open access peer-reviewed

4. Multipotent Stromal Cells in a Tumor Microenvironment

By Flavia Alejandra Bruna


Open access peer-reviewed

5. Stromal-Epithelial Interactions during Mammary Gland Development

By Żaneta Dzięgelewska and Małgorzata Gajewska


Open access peer-reviewed

6. Molecular Aberrations in Bone Marrow Stromal Cells in Multiple Myeloma

By Olga Blau, Rimma Berenstein, Marlies Wächter, Axel Nogai, Aline Künel, Mirgul Bayanova and Igor Wolfgang Blau


Open access peer-reviewed

7. Mesenchymal Stromal Cells as a Therapeutic Intervention

By Ivonne Hernandez Schulman and Joshua M. Hare


Open access peer-reviewed

8. Therapeutic Strategies of Secretome of Mesenchymal Stem Cell

By Daniel Ascencio González, Rogelio Hernández Pando, Miguel Ángel Gómez Lim, Sergio Ayala Fraustro and Aaron Torres Garcia


Open access peer-reviewed

9. Clinical Applications of Mesenchymal Stromal Cells (MSCs) in Orthopedic Diseases

By Jiazhao Yang, Shiyuan Fang, Lei Xu, Li Li, Kai Xie, Jinsen Lu, Hao Wang, Xujin Wang and Lixin Kan

Corrigendum to: Clinical Applications of Mesenchymal Stromal Cells (MSCs) in Orthopedic Diseases

By Jiazhao Yang, Shiyuan Fang, Lei Xu, Li Li, Kai Xie, Jinsen Lu, Hao Wang, Xujin Wang and Lixin Kan

Open access peer-reviewed

10. Human Placenta-Derived Mesenchymal Stromal Cells: A Review from Basic Research to Clinical Applications

By Paz de la Torre, María Jesús Pérez-Lorenzo and Ana I. Flores


Edited Volume and chapters are indexed in

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  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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