1. Introduction
The history of silicon nitride (Si3N4) has been described previously; detailed analyses of particles of meteroritic rock have been shown to contain silicon nitride crystals, suggesting that this material exists naturally in the galaxy.[1] Synthetic Si3N4 was probably developed by Deville and Wöhler in 1859. Commercial interest in this material increased in the 1950s, as the material properties of silicon nitride were better understood, and its application in internal combustion engines was contemplated.
Today, industrial applications of silicon nitride ceramics and related composites are common; these include bearings, turbine blades, and glow plugs, related to the fact that silicon nitride has high fracture toughness, strength, and attractive wear properties.[2] Ceramic ball bearings made of silicon nitride, for example, have been used in technical applications, and their extreme strength has been validated using a number of techniques. [3] These material qualities have led many investigators to speculate that silicon nitride may also have applicability in biomedical fields, especially since it exhibits biocompatibility [4,5] and is visible on plain radiographs as a partially radiolucent material. Because of the fortuitous combination of these properties, silicon nitride has been investigated for applications in skeletal repair, and for the bearings of prosthetic replacements of arthritic hip and knee joints.
Since clinical data are yet sparse, this review will attempt to give the reader an overview of the rationale for the use of silicon nitride in biomedical, specifically orthopaedic applications. As of the present time, surgical screws, plates, and bearings for use in prosthetic hip and knee joints have been developed and tested, using silicon nitride as the source material. [6-8] Cervical spacers and spinal fusion devices made of silicon nitride composites are presently in use, although clinical results have yet to be reported given the relatively short follow-up time. The goal of this chapter is to examine the scientific rationale to support the adoption of silicon nitride ceramics for use in biomedical, specifically, orthopaedic applications.
2. Clinical rationale for ceramics
Modern biomaterials, such as titanium alloys, polished cobalt-chromium, and high-density polyethylene have revolutionized orthopaedic surgery since the 1970’s, such that at the present time, total hip replacement and total knee replacement for diseased joints are commonplace around the world, with very predictable and durable outcomes. [9,10] One concern, over the long-term, is the host biological response to accumulated, microscopic wear debris particles in the periprosthetic joint space. Strategies to decrease bearing wear in the ball-and-socket joint of artificial hip joints, and the sliding-rolling articulation of artificial knee joints have been pursued vigorously by orthopaedic implant manufacturers and material scientists, with variable success.
The bearing surface credited with ushering in modern hip and knee replacement surgery is metal-on-polyethylene, specifically, a highly polished cobalt chromium surface articulating against a polyethylene surface. In total hip replacements, cobalt-chromium femoral heads are still used widely by surgeons, usually with prosthetic socket components made of ultrahigh-molecular-weight or cross-linked polyethylene. In total knees, the femoral components are made of cobalt-chromium that articulate with a polyethylene spacer, designed to reproduce, at least in part, the complex articular geometry of the human knee joint.
The cross-linking of polyethylene is a manufacturing strategy designed to reduce the incidence of bearing wear in prosthetic hip and knee joints. [11,12] Low wear is desirable since particulate wear in hip and knee replacement ultimately results in inflammation, periprosthetic bone loss, and premature implant loosening, necessitating repeat surgery. These considerations apply even more acutely to the young and active patients who will place greater demands on the prosthetic joint. Alumina and zirconia ceramics were introduced to replace metal surfaces in joint replacement surgery; the goal was to offer a smooth, low-friction surface that could reduce wear more than the metal-polyethylene bearings. Evidence has shown reduced wear when ceramic surfaces are used in hip [13,14] and knee [15] replacement surgery, instead of metal.
Despite their promising role in orthopaedic bearings, zirconia and alumina ceramics have had their drawbacks.Zirconia is an unstable material that can undergo phase transformation
2.1. Material Properties of Silicon Nitride
Silicon nitride has been developed as an industrial ceramic for more than 50 years, and during that time, its mechanical properties have been significantly improved by refining processing methods, and using additives to create composite structures. Of the different processing methods used to make silicon nitride, there are two typical processing routes, known as reaction-bonding and hot isostatic processing (HIP), respectively. Reaction-bonded silicon nitride processing is a method to produce ceramic material by incorporation and nitridation of silicon powders; this method was developed in the 1950s with the goal of developing internal combustion engines with hot-zone components made entirely from ceramics. [1] The resulting material has relatively low density, high porosity, and low strength. The HIP method was developed to address these concerns; it uses silicon nitride powder as the raw material and various sintering additives to produce bulk Si3N4 in confined graphite dies under a hot, nitrogen environment. Silicon nitride thus prepared has improved strength, albeit at a higher manufacturing cost. [21] A compromise is to combine the two technologies; thus, Si3N4 can be made by post-sintering the reaction-bonded silicon nitride in order to achieve a relatively high strength, at a fraction of the fabrication cost of HIPed Si3N4.
Polished test bars with a shape of 3 x 4 x 30 mm made of silicon nitride with 10% Y2O3 and Al2O3 as additives have shown an initial bending strength of approximately 600 MPa; ion implantation of the structural ceramic can increase this strength significantly, as shown by Shi et al. [22] These investigators found increases in specimen bending strength of 56%, 66%, and 35% by the implantation of Ti, Zr, and Cr ions, respectively. [22] Silicon nitride, like other ceramics, is a brittle material; typical material property tests have shown that silicon nitride has a Vickers hardness of 12-13 GPa; Young’s modulus of 299 GPa, Poisson’s ratio of 0.270, and a typical grain size of 0.59 µm. [23]
Composites of silicon nitride with 6 wt% yttrium oxide and 4 wt% alumina were fabricated to measure mechanical strength and related properties, according to ASTM C-1161 standards, using specimens with dimensions of 3 x 4 x 45 mm; results showed a near 100% theoretical material density (3.20 g/cm3), average grain width of 1.5 µm, flexural strength of 923 ± 70 MPa, with a Weibull modulus of 19 and a fracture toughness of 10 ± 1 MPa.m½. [24] Both material strength and toughness are at least an order of magnitude higher than typical values reported for alumina, the most common ceramic bearing material in orthopaedic bearings today. These data have been validated by other authors; using two less favorable compositions of silicon nitride doped with yttrium and aluminum, Guedes et al reported a fracture toughness of 5 MPa m½ and Vickers hardness values of 13 GPa. [25]
The intrinsic material properties of silicon nitride make it suitable for articulation against bearing steel, which is a softer material than ceramic. Thus, silicon nitride has been used in rolling contact applications in automotive, turbomachinery, and power industries, where it has a significant advantage due to its low density (half that of bearing steel), low friction, corrosion resistance, and reliable performance under extreme conditions. [21] In modern aircraft and space vehicles, very demanding bearing operating conditions such as high vacuum (<10-6 Torr), extreme temperatures (e.g. +230 to -150°C), long life (both wear and fatigue life, usually 10-15 years without maintenance) and low friction are common requirements. [26]
Fully densified Si3N4 has many advantages in such extreme applications; all-ceramic silicon nitride ball or roller bearings can operate against silicon nitride rolling elements and rings at temperatures up to 1000°C, at very high speeds. Hybrid ceramic-steel bearings perform just as well under these conditions; silicon nitride ceramic bearings in industry have met the requirements of higher efficiency, greater stiffness, higher speed, higher reliability, higher accuracy, lower friction, corrosion-resistance, and non-conductivity. [26] Thus, from a mechanical standpoint, silicon nitride ceramic should be adaptable to orthopaedic bearings, whether articulating against polyethylene, metal, or silicon nitride itself. [8] Practical barriers to widespread adoption of this technology are related to material and processing costs, and the need for reproducibility and reliability; these problems are common to all ceramic-powder blending and sintering processes.
3. Tribologicalproperties of silicon nitride
The suitability of silicon nitride for hip and knee bearings has been debated in the literature, but most authors agree that in the absence of material oxidation
Studies on the tribological behavior of ceramics have shown that the wear mechanisms depend on contact conditions during laboratory testing. In most structural ceramics such as silicon nitride, wear occurs through a small-scale surface fracture process if the contact load exceeds a threshold value specific to that material. Another mechanism whereby wear can be generated is surface oxidation of the material. In laboratory testing with pure silicon nitride, both mechanisms of wear have been confirmed. [28] Accordingly, for stable, long-term steady performance of silicon nitride orthopaedic bearings, a chemically-inert material composition that is impervious to surface oxidation is mandatory. Precise control of the raw powders and processing parameters is critical in manufacturing bearing components with predictable, reliable
Laboratory investigations using finite element analyses support the use of silicon nitride in load-bearing hip resurfacing components; these differ from hip replacement in that the diseased femoral head is resurfaced with a prosthetic cap, rather than being cut out and replaced entirely. [32] Stress distributions in the proximal femur bone with implanted silicon nitride hip prostheses are similar to those of intact, healthy bone. Mazzocchi et al investigated silicon nitride ceramics for their potential use in orthopaedic implants, and validated several properties that are critical to biomedical applications, such as wetting behavior and wear performance that simulates conditions typical of a hip joint prosthesis. [33] In three different silicon nitride ceramic materials prepared, these investigators found a lower contact angle of water when compared to oxide ceramics such as alumina and zirconia. Also, very low friction coefficients were consistently measured with undetectable surface modifications and wear tracks in the silicon nitride materials tested, using a disc-on-ball model of wear detection. [33]
4. Material stability of silicon nitride
A key concern in evaluating the use of any new material for
Surface modifications for different silicon nitride material preparations were investigated for a duration of 45 days, using liquid media water and isotonic physiological saline solution. [33] Both weight changes in the specimens, and scanning electron microscopic examination of the exposed surfaces were done to identify morphological and chemical modifications. These experiments showed a very limited surface modification related to exposure to oxygen-containing media; the newly formed phases were limited to the boundary zone, in the nano-scale. [33] Silicon nitride ceramics contain, besides silicon nitride grains, the grain boundary phases formed by sintering additives, and SiO2 that usually exists on the surface of the starting silicon nitride powders. Independent of additives, during sintering, SiO2 partially decomposes forming surface gradients, or even leads to metallic Si inclusions in the ceramic. The often-used additive Al2O3 partially dissolves into the Si3N4 grains by a chemical reaction; the resulting boundary phase has a decisive influence on the mechanical properties and oxidative behavior of the bulk ceramic. Different Y2O3/Al2O3 containing silicon nitride ceramics with amorphous grain boundaries exhibit varying degrees of corrosion-resistance, even to acids. [34]
Aluminum implantation into raw silicon nitride is a valid strategy to control material oxidation that is mediated by sodium. [35] The beneficial role of aluminum is in surface modification of the ceramic, so that sodium-accelerated oxidation processes can be reversed. In addition, the surface morphology and phase characteristics of the oxides are enhanced, resulting in smooth and glassy oxide layers that may play a protective role during oxidation. Related work has identified the optimal concentrations of aluminum ion implantation necessary for the optimization of the oxidation resistance of Si3N4 ceramics. [36]
Accelerated aging
5. Biocompatibility of silicon nitride
A requirement of any material used for
Not only are silicon nitride ceramics non-toxic, but the material may encourage cell adhesion, normal proliferation, and differentiation. Neumann et al investigated silicon nitride ceramics of different surface properties, with titanium alloy as a reference; cytotoxicity testing, cell viability, and morphology assessment were performed applying the L929-mice fibroblast cell culture model in a direct contact assay. [40] These investigators reported favorable results with all silicon nitride materials tested; cell growth, viability, and morphology were comparable to titanium, and polished silicon nitride surfaces appeared to promote cell growth. Further investigation compared industrial-grade silicon nitride using the L929-cell culture model, with alumina and titanium alloy as controls. [41] Again, silicon nitride ceramics showed no cytotoxicity and favorable physicochemical properties. Investigators concluded that silicon nitride ceramic should be considered for biomedical applications.
The biocompatibility of Si3N4 has also been assessed in an in vitro model using the human osteoblast-like MG-63 cell line. [42] Results showed that silicon nitride is a non-toxic, biocompatible ceramic surface for the propagation of functional human bone cells in vitro. Its high wear resistance and ability to support bone cell growth and metabolism make silicon nitride an attractive candidate for clinical application. Cappi et al performed mechanical investigations and cell culture tests with mouse fibroblast cells (L929) and human mesenchymal stem cells on silicon nitride; excellent cytocompatibility was demonstrated by live/dead staining for both types of cells. [43] Furthermore, the human mesenchymal stem cells were able to differentiate towards osteoblasts on all silicon-based ceramic materials tested. Guedes et al implanted silicon nitride ceramic constructs into rabbit tibias for 8 weeks, and showed no adverse reaction, with bone ingrowth occurring into and around the implants. [44] In a separate investigation, the authors also found that silicon nitride-based ceramics did not elicit any toxic response when tested with standard cell culture models. [25]
Howlett et al investigated the effect of silicon nitride on rabbit marrow stromal cells and their differentiation when grown in vitro and
6. Orthopaedic applications of silicon nitride
Ceramic materials have been used in orthopaedic bearings for several decades; their advantages over cobalt-chrome metal in terms of low friction and improved wear qualities are well known, and have been reviewed extensively. [45] Silicon nitride ceramic materials are markedly different from the other, alumina-based ceramics presently used in orthopaedic surgery. While alumina, and oxidized zirconium are used presently in the bearings of total hip [46-49], and total knee replacements [50-53], one unique property of silicon nitride ceramics pertains to its ability to be formulated into a porous substrate as well as a hard glassy bearing surface. As a porous material, silicon nitride is capable of direct bone ingrowth. Of all ceramic materials used in biomedical applications therefore, silicon nitride is the only one that addresses the possibility of monolithic implants, capable of an articulating smooth surface on one side, with a porous ingrowth surface fabricated on the opposing side of the same implant. Thus, several skeletal applications of silicon nitride are feasible.
Total joint replacements, like prosthetic hip and knee arthroplasty, require materials with low wear rates and favorable frictional coefficients that remain stable
Osteofixation using plates and screws, such as in maxillofacial surgery is another potential application of silicon nitride. Unlike metal devices, silicon nitride is partially radiolucent, which means that both the implant and the underlying bone can be visualized on plain radiography. Such is not the case with metal implants. Reaction-bonded porous silicon nitride yields an implant material suitable for spinal surgery, particularly fusion of intervertebral bodies; in this application, silicon nitride has already been in clinical use in the United States for at least two years, with no reports of adverse effects. [55] Other potential biomedical applications of silicon nitride include drug-release devices, microelectro-mechanical systems (Bio-MEMS), and traumatic reconstructions of otorhinolaryngologic skeletal defects. [56-59]
A cancellous-structured porous silicon nitride composite ceramic has been developed and is in commercial use as a spinal fusion implant; cylindrical implants have shown bone ingrowth rates similar to those reported for porous titanium, indicating that porous silicon nitride is an excellent substrate for implants designed for direct, biological skeletal fixation. [60] New bone forms even in the cortical region of the rabbit tibia, and around silicon nitride implants, suggesting that the material is osteoconductive, and promotes stable osseous fixation. [61]
7. Conclusions
Ceramic materials have remarkable properties that have fueled speculation about their potential applications in the biomedical field, where the need for improved biocompatibility, strength, endurance, reliability, and related properties is especially acute. Oxide ceramics such as zirconium and alumina have been used in skeletal reconstruction; specifically as bearings in total hip and knee replacements. Today, alumina is the most common ceramic bearing used in orthopaedic surgery, and oxidized zirconium has replaced zirconia as a bearing surface.
As the world population increases, the demand for maintaining an active, healthy lifestyle has increased and will likely do so for the foreseeable future. Consistent with this demand, the need for artificial hip and knee replacements has continued a steady upward trend, especially in economically developed nations. [62] The limitations of the materials used in orthopaedic joint reconstructions are evident in the significant burden of repeat surgery, with attendant increases in costs and morbidity, associated with failed total hip and knee replacements. [63,64] Improved materials, such as silicon nitride composites, when thoroughly investigated in terms of their mechanical properties and suitability for
References
- 1.
Riley FL. 2000 Silicon Nitride and Related Materials. ;83 2 245 265 - 2.
Brook RE. 1991 : Pergamon Press: Oxford;. - 3.
Supancic P. Danze R. Harrer W. Wang Z. Witschnig S. Schöppl O. 2009 Strength tests on silicon nitride balls.409 - 4.
Howlett C. R. Mc Cartney E. Ching W. 1989 The effect of silicon nitride ceramic on rabbit skeletal cells and tissue. An in vitro and investigation. Clinical Orthopaedics and Related Research. (244):293-304. - 5.
Neumann A. Jahnke K. Maier H. R. Ragoß C. 2004 Biocompatibility of silicon nitride ceramic in vitro. A comparative fluorescence-microscopic and scanning electron-microscopic study. ;83 12 845 851 - 6.
Neumann A. Unkel C. Werry C. et al. 2006 Osteosynthesis in facial bones. Silicon nitride ceramic as material. ;54 12 937 942 - 7.
Neumann A. Unkel C. Werry C. et al. 2006 Prototype of a silicon nitride ceramic-based miniplate osteofixation system for the midface. ;134 6 923 930 - 8.
BS Bal Khandkar. A. Lakshminarayanan R. Clarke I. AA Hoffman Rahaman. M. N. 2008 Testing of silicon nitride ceramic bearings for total hip arthroplasty. ;87 2 447 454 - 9.
Kowalczewski J. B. Milecki M. Marczak D. 2005 What’s new in total hip replacement?]. ;70 6 401 405 - 10.
Blumenfeld TJ, Scott RD. 2010 The role of the cemented all-polyethylene tibial component in total knee replacement: a 30-year patient follow-up and review of the literature. Dec;17 6 412 416 - 11.
Lachiewicz PF, Geyer MR. 2011 The use of highly cross-linked polyethylene in total knee arthroplasty. Mar;19 3 143 151 - 12.
Capello W. N. D’Antonio J. A. Ramakrishnan R. Naughton M. 2011 Continued improved wear with an annealed highly cross-linked polyethylene. Mar;469 3 825 830 - 13.
Bascarevic Z. Vukasinovic Z. Slavkovic N. et al. 2010 Alumina-on-alumina ceramic versus metal-on-highly cross-linked polyethylene bearings in total hip arthroplasty: a comparative study. Dec;34 8 1129 1135 - 14.
Kim-H Y. Choi Y. Kim-S J. 2011 Cementless total hip arthroplasty with alumina-on-highly cross-linked polyethylene bearing in young patients with femoral head osteonecrosis. Feb;26 2 218 223 - 15.
Oonishi H. Kim S. C. Kyomoto M. Masuda S. Asano T. Clarke I. C. 2005 Change in UHMWPE properties of retrieved ceramic total knee prosthesis in clinical use for 23 years. Aug;74 2 754 759 - 16.
Clarke I. C. Manaka M. Green D. D. et al. 2003 Current status of zirconia used in total hip implants. Journal of Bone & Joint Surgery- American85-A Suppl 4:73-84. - 17.
Fukui K. Kaneuji A. Sugimori T. Ichiseki T. Kitamura K. Matsumoto T. 2011 Wear comparison between a highly cross-linked polyethylene and conventional polyethylene against a zirconia femoral head: minimum 5-year follow-up. Jan;26 1 45 49 - 18.
Nakahara I. Nakamura N. Nishii T. Miki H. Sakai T. Sugano N. 2010 Minimum five-year follow-up wear measurement of longevity highly cross-linked polyethylene cup against cobalt-chromium or zirconia heads. Dec;25 8 1182 1187 - 19.
Iwakiri K. Iwaki H. Minoda Y. Ohashi H. Takaoka K. 2008 Alumina inlay failure in cemented polyethylene-backed total hip arthroplasty. May;466 5 1186 1192 - 20.
Rhoads D. P. Baker K. C. Israel R. Greene P. W. 2008 Fracture of an alumina femoral head used in ceramic-on-ceramic total hip arthroplasty. Dec;23(8):1239.e1225 1230 - 21.
Wang W. Hadfield M. AA Wereszczak 2009 Surface strength of silicon nitride in relation to rolling contact performance. ;35 8 3339 3346 - 22.
Shi F. Miao H. Peng Z. Si W. Qi L. Li W. 2005 Bending strength of ceramics implanted by titanium, zirconium, and chromium ions with MEVVA source.280-283 - 23.
Chen FC, Ardell AJ. 2000 Fracture toughness of ceramics and semi-brittle alloys using a miniaturized disk-bend test. ;3 5 250 262 - 24.
Bal BS, Khandkar A, Lakshminarayanan R, Clarke I, Hoffman AA, Rahaman MN. 2009 Fabrication and Testing of Silicon Nitride Bearings in Total Hip Arthroplasty. Winner of the 2007 "HAP" PAUL Award. Journal of Arthroplasty.;1 24 110 116 - 25.
Guedes e Silva CC, Higa OZ, Bressiani JC. 2004 Cytotoxic evaluation of silicon nitride-based ceramics. ;24 5 643 646 - 26.
Wang L. Snidle R. W. Gu L. 2000 Rolling contact silicon nitride bearing technology: A review of recent research. ;246(1-2):159-173. - 27.
Mazzocchi M. Bellosi A. 2008 On the possibility of silicon nitride as a ceramic for structural orthopaedic implants. Part I: Processing, microstructure, mechanical properties, cytotoxicity. ;19 8 2881 2887 - 28.
Jahanmir S. 2002 Wear transitions and tribochemical reactions in ceramics. ;216 6 371 385 - 29.
Iliev C. 2010 On the wear behaviour of silicon nitride sliding against metals in water. ;62 1 32 36 - 30.
Blewis ME, Nugent-Derfus GE, Schmidt TA, Schumacher BL, Sah RL. 2007 A model of synovial fluid lubricant composition in normal and injured joints. ;13 26 39 - 31.
Mazzucco D. Spector M. 2004 The John Charnley Award Paper. The role of joint fluid in the tribology of total joint arthroplasty. Dec (429):17-32. - 32.
Zhang W. Titze M. Cappi B. Wirtz D. C. Telle R. Fischer H. 2010 Improved mechanical long-term reliability of hip resurfacing prostheses by using silicon nitride. ;21 11 3049 3057 - 33.
Mazzocchi M. Gardini D. Traverso P. L. Faga M. G. Bellosi A. 2008 On the possibility of silicon nitride as a ceramic for structural orthopaedic implants. Part II: Chemical stability and wear resistance in body environment. ;19 8 2889 2901 - 34.
Herrmann M. Schilm J. Hermel W. Michaelis A. 2006 Corrosion behaviour of silicon nitride ceramics in aqueous solutions. ;114 1335 1069 1075 - 35.
Cheong Y. S. Mukundhan P. Du H. H. Withrow S. P. 2000 Improved oxidation resistance of silicon nitride by aluminum implantation: I. Kinetics and oxide characteristics. ;83 1 154 160 - 36.
Cheong Y. S. Mukundhan P. Du H. H. Withrow S. P. 2000 Improved oxidation resistance of silicon nitride by aluminum implantation: II. Analysis and optimization. ;83 1 161 165 - 37.
Chowdhury S. Vohra Y. K. Lemons J. E. Ueno M. Ikeda J. 2007 Accelerating aging of zirconia femoral head implants: change of surface structure and mechanical properties. May;81 2 486 492 - 38.
Hayaishi Y. Miki H. Yoshikawa H. Sugano N. 2008 Phase transformation of a new generation yttria-stabilized zirconia femoral head after total hip arthroplasty. ;18 6 647 650 - 39.
Masonis J. L. Bourne R. B. MD Ries Mc Calden. R. W. Salehi A. Kelman D. C. 2004 Zirconia femoral head fractures: a clinical and retrieval analysis. Oct;19 7 898 905 - 40.
Neumann A. Jahnke K. Maier H. R. Ragoss C. 2004 Biocompatibilty of silicon nitride ceramic in vitro. A comparative fluorescence-microscopic and scanning electron-microscopic study]. Dec;83 12 845 851 - 41.
Neumann A. Reske T. Held M. Jahnke K. Ragoss C. Maier H. R. 2004 Comparative investigation of the biocompatibility of various silicon nitride ceramic qualities in vitro. Oct;15 10 1135 1140 - 42.
Kue R. Sohrabi A. Nagle D. Frondoza C. Hungerford D. 1999 Enhanced proliferation and osteocalcin production by human osteoblast-like MG63 cells on silicon nitride ceramic discs. Jul;20 13 1195 1201 - 43.
Cappi B. Neuss S. Salber J. Telle R. Knüchel R. Fischer H. 2010 Cytocompatibility of high strength non-oxide ceramics. ;93 1 67 76 - 44.
Guedes E. Silva C. C. König Jr B. MJ Carbonari Yoshimoto. M. Allegrini Jr S. Bressiani J. C. 2008 Tissue response around silicon nitride implants in rabbits. ;84 2 337 343 - 45.
BS Bal Garino. J. Ries M. Rahaman M. N. 2006 Ceramic Materials in Total Joint Arthroplasty. ;17(3-4):94-101. - 46.
Lewis P. M. Al-Belooshi A. Olsen M. Schemitch E. H. Waddell J. P. 2010 Prospective randomized trial comparing alumina ceramic-on-ceramic with ceramic-on-conventional polyethylene bearings in total hip arthroplasty. Apr;25 3 392 397 - 47.
Lombardi AV, Jr., Berend KR, Seng BE, Clarke IC, Adams JB. 2010 Delta ceramic-on-alumina ceramic articulation in primary THA: prospective, randomized FDA-IDE study and retrieval analysis. Feb;468 2 367 374 - 48.
Garvin K. L. Hartman C. W. Mangla J. Murdoch N. Martell J. M. 2009 Wear analysis in THA utilizing oxidized zirconium and crosslinked polyethylene. Jan;467 1 141 145 - 49.
Good V. Ries M. Barrack R. L. Widding K. Hunter G. Heuer D. 2003 Reduced wear with oxidized zirconium femoral heads. Journal of Bone & Joint Surgery- American85-A Suppl 4:105-110. - 50.
Koshino T. Okamoto R. Takagi T. Yamamoto K. Saito T. 2002 Cemented ceramic YMCK total knee arthroplasty in patients with severe rheumatoid arthritis. Dec;17 8 1009 1015 - 51.
Vavrik P. Landor I. Denk F. 2008 Clinical evaluation of the ceramic femoral component used for reconstruction of total knee replacement]. Dec;75 6 436 442 - 52.
Innocenti M. Civinini R. Carulli C. Matassi F. Villano M. 2010 The 5-year results of an oxidized zirconium femoral component for TKA. May;468 5 1258 1263 - 53.
Tsukamoto R. Chen S. Asano T. et al. 2006 Improved wear performance with crosslinked UHMWPE and zirconia implants in knee simulation. Jun;77 3 505 511 - 54.
Luo M. Hou G. Y. Yang J. F. et al. 2009 Manufacture of fibrous β-Si<sub>3</sub>N<sub>4</sub>-reinforced biomorphic SiC matrix composites for bioceramic scaffold applications. ;29 4 1422 1427 - 55.
Sorrell C. C. Hardcastle P. H. Druitt R. K. Mc Cartney E. R. 1999 Paper presented at: Proceedings 5th Meeting and Seminar on: Implants for Spine, Ceramics, Cells and Tissues annaul conferences; Faenza, Italy. - 56.
Kotzar G. Freas M. Abel P. et al. 2002 Evaluation of MEMS materials of construction for implantable medical devices. Jul;23 13 2737 2750 - 57.
Kristensen B. W. Noraberg J. Thiebaud P. Koudelka-Hep M. Zimmer J. 2001 Biocompatibility of silicon-based arrays of electrodes coupled to organotypic hippocampal brain slice cultures. Mar 30;896(1-2):1-17. - 58.
Davis DH, Giannoulis CS, Johnson RW, Desai TA. 2002 Immobilization of RGD to < 1 1 1 > silicon surfaces for enhanced cell adhesion and proliferation. Oct;23 19 4019 4027 - 59.
Neumann A. Unkel C. Werry C. et al. 2006 Osteosynthesis in facial bones: silicon nitride ceramic as material]. Dec;54 12 937 942 - 60.
Anderson M. C. Olsen R. 2010 Bone ingrowth into porous silicon nitride. ;92 4 1598 1605 - 61.
Guedes e. Silva C. C. König Jr B. MJ Carbonari Yoshimoto. M. Allegrini Jr S. Bressiani J. C. 2008 Bone growth around silicon nitride implants-An evaluation by scanning electron microscopy. ;59 9 1339 1341 - 62.
Otten R, van Roermund PM, Picavet HSJ. 2010 [Trends in the number of knee and hip arthroplasties: considerably more knee and hip prostheses due to osteoarthritis in 2030]. Nederlands Tijdschrift voor Geneeskunde.;154:A1534 - 63.
Oduwole KO, Molony DC, Walls RJ, Bashir SP, Mulhall KJ. 2010 Increasing financial burden of revision total knee arthroplasty. Jul;18 7 945 948 - 64.
Ong K. L. Mowat F. S. Chan N. Lau E. Halpern M. T. Kurtz S. M. 2006 Economic burden of revision hip and knee arthroplasty in Medicare enrollees. May;446 22 28