Open access peer-reviewed Edited Volume


An Ongoing and Significant Challenge

Edited by Luciano Azevedo

University of Sao Paulo, Brazil

Sepsis is the major cause of death in non-cardiologic intensive care units around the world. Every year, billions of dollars are consumed in the treatment of sepsis and in research to understand its complex pathophysiology and therefore obtain future therapeutic opportunities. Despite the efforts of the scientists and medical practitioners, the mortality rates are still high and the incidence of sepsis is increasing. In this book we provide an update on several aspects of sepsis. Starting from the history of the disease and finishing with treatment of sepsis-associated organ dysfunctions, this book offers a wide scope of well-written and complete reviews concerning pathophysiological and therapeutic characteristics of sepsis. We hope that the work of the authors will provide a significant forum of discussion on the topic, and increase the awareness of the healthcare team regarding the important aspects of early recognition and treatment of this severe condition.

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SepsisAn Ongoing and Significant ChallengeEdited by Luciano Azevedo

Published: October 3rd 2012

DOI: 10.5772/2958

ISBN: 978-953-51-0780-4

eBook (PDF) ISBN: 978-953-51-7032-7

Copyright year: 2012

Books open for chapter submissions

79499 Total Chapter Downloads

17 Crossref Citations

21 Web of Science Citations

46 Dimensions Citations


Open access peer-reviewed

1. The History of Sepsis from Ancient Egypt to the XIX Century

By Johan Sebastián Hernández Botero and María Cristina Florián Pérez


Open access peer-reviewed

2. Experimental Sepsis Models

By Safiah Mai, Momina Khan, Patricia Liaw and Alison Fox-Robichaud


Open access peer-reviewed

3. Sepsis, the Liver and the Gut

By Neville Azzopardi, Manuel Fenech and Tonio Piscopo


Open access peer-reviewed

4. Nerve Growth Factor and Sepsis

By Ayse Belin Ozer and Mustafa Bayar


Open access peer-reviewed

5. Nicotinamide Phosphoribosyltransferase in Sepsis

By Peixin Huang, Ding You Li, Daniel P. Heruth, Li Qin Zhang, Dmitry N. Grigoryev and Shui Qing Ye


Open access peer-reviewed

6. Neural Reflex Control of Inflammation During Sepsis Syndromes

By Ricardo Fernandez and Claudio Acuña-Castillo


Open access peer-reviewed

7. Early Detection of Sepsis, MOF and Outcome Prediction in Severely Traumatized Patients

By Zeljko Lausevic and Mirjana Lausevic


Open access peer-reviewed

8. New Biomarkers for Sepsis

By Lixin Xie


Open access peer-reviewed

9. The Role of Procalcitonin in the Early Diagnosis of Septic and Non-Septic Complications in the Immediate Postoperative Setting After Orthotopic Liver Transplantation

By Aristotelis Perrakis, Volker Müller, Werner Hohenberger and Roland S. Croner


Open access peer-reviewed

10. Microdialysis Monitoring of Biomarkers for Early Recognition of Intestinal Ischemia

By Radha Swathe Priya M. and Emma P. Córcoles


Open access peer-reviewed

11. Challenges in the Diagnosis of Sepsis of the Neonate

By Bernhard Resch, Nora Hofer and Wilhelm Müller


Open access peer-reviewed

12. Relevance of Procalcitonin for the Diagnosis of Early and Late-Onset Sepsis in Newborns

By C. Savagner, B. Leboucher, G. Gascoin-Lachambre and C. Gras-Leguen


Open access peer-reviewed

13. Catheter-Related Bloodstream Infections in Critical Care

By Efraín Riveros Pérez


Open access peer-reviewed

14. Beware of Unusual Organisms Masquerading as Skin Contaminants

By Marilynn R. Fairfax and Hossein Salimnia


Open access peer-reviewed

15. Blood Culture Systems: From Patient to Result

By Andries William Dreyer


Open access peer-reviewed

16. Sepsis: Antimicrobial Therapy

By Renato Finkelstein and Ilana Oren


Open access peer-reviewed

17. Infections in Leukemia

By Rekha Chandran, Morgan Hakki and Stephen Spurgeon


Open access peer-reviewed

18. Continuous Renal Replacement Therapies in Patients with Severe Sepsis and Septic Shock

By F.J. García-Miguel


Open access peer-reviewed

19. Induction Agents for Endotracheal Intubation in Severe Sepsis and Septic Shock

By Marie Mullen


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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