Open access peer-reviewed chapter

Colonoscopy — Indications and Contraindications

By Jigar Bhagatwala, Arpit Singhal, Summer Aldrugh, Muhammed Sherid, Humberto Sifuentes and Subbaramiah Sridhar

Submitted: November 26th 2014Reviewed: June 23rd 2015Published: December 2nd 2015

DOI: 10.5772/61097

Downloaded: 4367

Abstract

This chapter discusses some of the major indications and contraindications for colonoscopy. Advances in colonoscopic techniques have expanded the role of colonoscopy beyond conventional screening, surveillance, and diagnosis to various complex therapeutic and interventional utilities. Several guidelines with new information are being published and updated regularly in the field of colonoscopy and are currently used in clinical practice. However, there is still a lack of well-designed randomized clinical trials investigating the role of colonoscopy in early diagnosis and treatment of various conditions and its impact on long-term survival and disease status. Nevertheless, retrospective observational studies and a few randomized clinical trials abundantly supply data supporting the role of colonoscopy in the diagnosis and management of colonic pathologies in the absence of comparable alternatives.

Keywords

  • Colonoscopy
  • Indication
  • Contraindication
  • Screening
  • Surveillance
  • Diagnostic
  • Therapeutic

1. Introduction

In the 1960s, Drs. William Wolff and Hiromi Shinya developed a way to probe the full length of the colon using a tube with electronic sensors [1]. Since its inception, colonoscopy has become a very popular method for screening of colorectal cancers and for treating a variety of conditions of the lower gastrointestinal tract. The decision to perform colonoscopy should take into account the indication and contraindication for the procedure, the risks of the procedure, and the cost. A key quality measure of colonoscopy is the indication for the procedure, because as high as 20-50% of colonoscopies are performed for inappropriate indications [2]. Performing colonoscopy for inappropriate indications not only exposes patients to procedure-related complications such as bowel perforation, bleeding, infection, and cardiovascular events, but also increases on the health-care-related cost. Therefore, several societies including the American Society of Gastrointestinal Endoscopy (ASGE) and the European Panel on the Appropriateness of Gastrointestinal Endoscopy (EPAGE), have established guidelines for appropriate use of colonoscopy. In this chapter, we aim to outline the common indications and contraindications for performing colonoscopy and detail the evidence supporting the facts.

2. Indications for colonoscopy (table 1)

2.1. Lower gastrointestinal (GI) bleeding

Lower GI bleeding may occur in the form of occult bleeding, melena, scant intermittent hematochezia, or severe hematochezia [3]. Lower GI bleeding from any cause requires colonoscopy either urgently or routinely. Patients with occult GI bleeding require colonoscopy to exclude malignant or adenomatous etiologies. Patients who are not good candidates for colonoscopy can be evaluated using CT colonography [4]. In patients presenting with melena, upper GI endoscopy is performed first to identify any upper GI causes. If the upper GI endoscopy does not reveal a source of bleeding, colonoscopy is then indicated to identify any colonic source. Intermittent scant hematochezia can be diagnosed by anoscopy with/without sigmoidoscopy for low-lying lesions in the anus, rectum, and sigmoid in patients who are younger than 40. However, colonoscopy may still be required if a definitive source cannot be identified. On the other hand, colonoscopy is the recommended procedure for patients with intermittent hematochezia who have one of the following risk factors: age >50, family history of colon cancer, or other alarming symptoms such as weight loss, anemia, and change in bowel habits [5, 6]. Overall, colonoscopy has been reported to have a higher yield than other modalities such as proctosigmoidoscopy, single-contrast barium studies, or combined flexible sigmoidoscopy and double-contrast barium enema for diagnosis of lower GI bleeding. In case of severe hematochezia, hemodynamic stability determines the diagnostic and therapeutic approach [7-9]. In hemodynamically stable patients, urgent (within 8-24 h) colonoscopy is recommended [10-13]. In critically ill patients, upper endoscopy is indicated first followed by colonoscopy after excluding the upper GI tract as the source of bleeding [14]. The therapeutic indications of colonoscopy for the treatment of lower GI bleeding are discussed separately in this chapter.

Indications for colonoscopy:
1.Lower GI bleeding
2.Screening and surveillance of colorectal polyps and cancers:
a. Colon cancer
b. Surveillance after polypectomy
c. Colorectal cancer post-resection surveillance
d. Inflammatory bowel diseases
3.Acute and chronic diarrhea
4.Therapeutic indications for colonoscopy:
a. Excision and ablation of lesions
b. Treatment of lower GI bleeding
c. Colonic decompression
d. Dilation of colonic stenosis
e. Foreign body removal
5.Miscellaneous indications:
a. Abnormal radiological examinations
b. Isolated unexplained abdominal pain
c. Chronic constipation
d. Preoperative and intraoperative localization of colonic lesions

Table 1.

Indications for colonoscopy

2.2. Screening and surveillance of colorectal polyps and cancers

2.2.1. Colon cancer

According to the World Health Organization report in 2012, colorectal cancer (CRC) is the third most common cancer in men (746,000 cases, 10% of the total) and the second in women (614,000 cases, 9.2% of the total) worldwide. In 2014, the American Cancer Society predicted that about 136,830 people would be diagnosed with colorectal cancer in the United States, and about 50,310 people were predicted to die of the disease. Recent studies show declining in the CRC incidence and mortality rates, which have been attributed to the awareness of the risk factors and reduced exposure to them, the effect of early detection and prevention through polypectomy, and improved treatment [15]. The recommendations for screening colonoscopies are divided based on the known risk factor profile: 1) screening in the average-risk population and 2) screening in patients with a family history of colon cancer.

In the average-risk patient, current American, European, and Asian guidelines recommend beginning CRC screening with colonoscopy at the age of 50 years and every 10 years thereafter regardless of the gender. However, the American College of Gastroenterology recommends that the screening colonoscopy begin at the age of 45 years in African Americans [16, 17]. Published evidence favoring the effectiveness of colonoscopy in reducing mortality from CRC by routine colonoscopy is insufficient because of a lack of randomized controlled trials and the limited consensus in guidelines on the appropriateness of colonoscopy. However, a few studies have modeled and predicted the impact of screening colonoscopy on CRC incidence and mortality using various transition models in hypothetical average-risk individuals aged 50 years. These studies have found that initial screening colonoscopy and repeat colonoscopy every 10 years might reduce CRC incidence by 58% and the reduction in CRC mortality is approximately 64% [18, 19]. In the average-risk individuals, yearly fecal occult blood testing (FOBT) and flexible sigmoidoscopy (FSIG) every 3 years are also accepted methods of screening for CRC. A follow-up colonoscopy, however, is warranted to completely visualize the entire length of the colon for patients with positive FOBT results or FSIG findings of adenoma in the distal colon [20-23].

Family history of CRC is a major risk factor for CRC. It has been estimated that the first-degree relatives of CRC patients have two- to threefold increased risk of dying from CRC, and the risk is inversely associated with the age of diagnosis of the affected family member [24]. Patients with a single first-degree relative with CRC or advanced adenoma (adenoma ≥1 cm in size, with high-grade dysplasia, or villous elements) diagnosed at age ≥60 years are recommended to undergo routine CRC screening same as an average-risk individual beginning at age 50 years. On the other hand, patients with a single first-degree relative with CRC or advanced adenoma diagnosed at age <60 years, or two first-degree relatives with CRC or advanced adenomas should receive colonoscopy every 5 years beginning at age 40, or 10 years earlier than the age at diagnosis of the youngest affected relative, whichever comes first [16]. The data supporting these recommendations emerge from the retrospective studies rather than the randomized control trials [25, 26].

Patients with a family history of hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant disease, are recommended to start the CRC screening at the age of 20-25 years or 10 years prior to the earliest age of HNPCC diagnosis in the patient’s family member, whichever comes first. The recommended interval for colonoscopy is every 1-2 years until age 40, then annually thereafter [27-30]. This condition, in particular, has two-thirds of adenomas occurring on the right side and warrants colonoscopy for complete colonic surveillance [31]. Indications for performing colonoscopy in individuals with a history of familial adenomatous polyposis (FAP) are guideline-dependent after genetic testing returns positive. FSIG and colonoscopy have not been compared head-to-head regarding their effectiveness and reducing mortality in patients with FAP in the clinical trials and, as such, either FSIG or colonoscopy annually is recommended, starting at the age of 10-12 years [16]. A colonoscopy is deemed necessary when polyps are detected on FSIG and a decision to perform polypectomy is made.

2.2.2. Surveillance after polypectomy

Post-polypectomy surveillance constitutes 20% of the performed colonoscopies, thereby constituting a large share in the amount of health care expenditure [32, 33]. Adhering to the indications for the repeat colonoscopy for the surveillance of CRC after the first colonoscopy, therefore, is very important as earlier colonoscopy can increase the risks to the patient and add to the health care cost whereas delaying the surveillance can also increase the risks by increasing the chances of missed interval cancers. Various observational studies report a 2-5% risk of an advanced neoplasia 5-10 years after a negative colonoscopy, a risk that is comparable to the risk of advanced colonic neoplasia in the average-risk patients undergoing their first colonoscopy [34-39]. Moreover, the risk of developing CRC 10 years after a negative colonoscopy is reported to be significantly lower (adjusted OR 0.26) [36, 40], supporting the current recommendation of repeat colonoscopy every 10 years in the average-risk general population.

Although the detection and removal of polyp(s) can offer a significant reduction in the mortality of CRC, the development of interval cancers, i.e., the cancers occurring after the initial colonoscopy with polypectomy, appears to be the highest in the first 3-5 years. In 2012, the United States Multi-Society Task Force (USMSTF) published a revision of the 2006 guidelines on post-polypectomy surveillance and divided recommendations based on the presence of polyp(s) (hyperplastic vs. adenomatous), the number and the size of adenomatous polyp(s), villous component and high-grade dysplasia in the polyp, and the presence of serrated lesions or serrated polyposis syndrome (>20 serrated polyps of any size throughout the colon) at baseline colonoscopy. In 2013, the European Society of Gastrointestinal Endoscopy (ESGE) published its post-polypectomy surveillance guidelines, stratifying risk into: low risk (1-2 adenomas <1 cm), intermediate risk (3-4 small adenomas or one >1 cm), and high risk (>5 small adenomas or >3 adenomas with at least one >1 cm) based on the first colonoscopy. According to the USMSTF guideline, it is indicated that patients with 1-2 tubular adenomas <1 cm have a repeat colonoscopy in 10 years; whereas patients with a high-risk adenoma (defined as adenoma with villous histology, high-grade dysplasia, adenoma>10 mm, or three or more adenomas) are recommended to have surveillance interval of 3 years. According to the ESGE guideline, the high-risk group should undergo surveillance at 1 year, the intermediate-risk group at 3-yearly intervals until two consecutive examinations are negative, and the low-risk group requires no surveillance colonoscopy or 5-yearly colonoscopy until one negative examination after which surveillance can be discontinued. The evidence supporting the indications in the arena of surveillance for the serrated polyp is insufficient. According to the USMSTF guideline, sessile serrated polyp(s) <1 cm with no dysplasia should be considered low risk and can be followed at a 5-year interval. However, sessile serrated polyp(s) ≥1 cm or sessile serrated polyp with dysplasia or serrated adenoma should undergo surveillance at 3 years and serrated polyposis syndrome should be surveyed annually. The ESGE recommends that patients with serrated polyps <10 mm in size without dysplasia should be classified as low risk, whereas patients with large serrated polyps (≥10 mm) or those with dysplasia as high risk and undergo surveillance accordingly. Patients with ≥5 serrated polyps proximal to the sigmoid, of which ≥2 are sized ≥10mm, or with ≥20 serrated polyps of any size are classified as serrated polyposis and should be referred for genetic testing.

2.2.3. CRC post-resection surveillance

There are no clear survival benefits for performing colonoscopy in patients who have had colon cancer resection. However, a majority of the groups and societies such as American Cancer Society (ACS), and a joint American Cancer Society/US Multi-Society Task Force on Colorectal Cancer, Cancer Care Ontario [41-44], recommend post CRC resection surveillance. An indication to perform colonoscopy in these patients will help detect metachronous CRCs and polyps as well as anastomotic recurrences of the initial primary cancer at a stage that would allow further treatment. Currently, a follow-up colonoscopy is indicated at 1 year after the surgical removal of CRC. If no new cancer or polyp(s) is identified, a colonoscopy is repeated at 3 years and at 5 years if the findings are negative for interval development of cancer. An exception to this indication is HNPCC, which requires colonoscopic surveillance every 1-2 years regardless of the surgical resection of the cancer.

2.2.4. Inflammatory bowel diseases and other colitis

The indications for colonoscopy in inflammatory bowel disease (IBD), namely ulcerative colitis (UC) and Crohn’s disease (CD) fall under a large spectrum. Colonoscopic diagnosis and differentiation between the UC and CD, assessment of the extent and severity of disease activity, treatment effectiveness, surveillance of malignancies, and endoscopic treatment, such as stricture dilation, are all within the scope of colonoscopy and its indications in IBD. Currently, American, European, and other international societies and guideline-defining bodies recommend endoscopic visualization of the entire colon for the initial diagnosis of IBD and other colitis [45-48]. The clinical presentation and laboratory data characterizing both diseases may overlap but endoscopic visualization of the mucosa of the rectum, colon, and terminal ileum, and the extent of the disease involvement may help differentiate the disease processes. Moreover, colonoscopy offers the opportunity to perform biopsy, which is the major advantage of colonoscopy. Unless contraindicated because of severe colitis or possible toxic megacolon, a full colonoscopy with intubation of the terminal ileum should be performed during the initial evaluation of patients with a clinical presentation suggestive of IBD. Ileoscopy is superior for the diagnosis of CD of the terminal ileum when compared with radiological methods, especially for mild lesions [49, 50]. During the colonoscopic examination, biopsy samples should be obtained both from areas affected by the disease and from unaffected areas. After initiating therapy, a smaller number of biopsy samples may be necessary to confirm the diagnosis. In postsurgical follow-up, biopsies of the neoterminal ileum are indicated when disease recurrence is suspected. In patients who have undergone ileal pouch-anal anastomosis, biopsies of the afferent limb are indicated when Crohn’s disease is suspected [46]. Other forms of colitis, such as drug-induced, infectious, vascular, and radiation colitis also present in a similar pattern and require colonoscopy at baseline for the diagnosis and the assessment of severity.

Patients with IBD have an increased risk of CRC compared to those without IBD [51-55]. In fact, CRC accounts for one-sixth of ulcerative colitis-related deaths [56]. There is a lack of randomized control studies demonstrating the effectiveness of colonoscopy in improving survival in the IBD patients from CRC. However, numerous observational studies have reported that colonoscopic surveillance of CRC in IBD offers early detection of cancers and improves CRC-related survival in IBD patients [57, 58]. In a retrospective study of 6,823 patients with IBD in US tertiary referral hospitals followed-up for at least 3 years, the incidence of CRC among patients without a recent colonoscopy was 2.7% which was significantly higher than among patients with a recent colonoscopy (1.6%) [59]. Additionally, a colonoscopy within 6-36 months before diagnosis was associated with a 64% reduction in mortality rate [59]. According to most guidelines, colonoscopies are indicated for CRC screening starting at 8-10 years from initiation of IBD-related symptoms [48, 53, 60-62]. The National Institute for Health and Clinical Excellence (NICE) London 2011 guideline, however, recommends only offering colonoscopic surveillance to patients with Crohn’s colitis involving more than 1 segment of the colon or left-sided or more extensive UC, but not isolated ulcerative proctitis. Most guidelines recommend yearly follow-up colonoscopy for high-risk patients (those with primary sclerosing cholangitis, extensive colitis, active endoscopic or histologic inflammation, a family history of CRC in a first-degree relative before 50 years of age, personal history of dysplasia, presence of strictures on colonoscopy, and, possibly, gender), and every 2-5 years for those without major risk factors.

2.3. Acute and chronic diarrhea

Patients presenting with acute diarrhea should undergo initial evaluation with stool studies. If blood and stool cultures are inconclusive, or if symptoms persist or worsen despite empiric therapy, then colonoscopy is indicated due to its high diagnostic yield [63]. For most patients with chronic diarrhea, patients with suspected acute diffuse Clostridium Difficile colitis, pregnant patients, patients with predominantly left-sided symptoms (tenesmus/urgency) and patients with multiple morbidities, a flexible sigmoidoscopy can be used for the initial evaluation. Even if patients have macroscopically normal-appearing mucosa, biopsies must be obtained to exclude microscopic diseases. If flexible sigmoidoscopy yields inconclusive results, if diarrhea persists, or if there is suspicion of inflammatory bowel disease (IBD) or cancer, then colonoscopy should be the next investigative study.

Histology is an integral component of colonoscopic evaluation of chronic diarrhea because several diseases, such as microscopic colitis, eosinophilic colitis, amyloidosis, and IBD, may appear normal on endoscopy but are abnormal on microscopy. In patients undergoing colonoscopy for chronic diarrhea, IBD or colitis is the most likely disease to be detected [64]. Microscopic colitis can be lymphocytic or collagenous and is characterized by nonbloody, watery diarrhea. On endoscopy, microscopic colitis can be missed because of patchy colonic involvement. Even if mucosa appears normal endoscopically, multiple biopsies from both sides of the colon are necessary to avoid missing microscopic colitis [65]. If there is suspicion of inflammatory diarrhea, then a biopsy of the terminal ileum is helpful in the diagnosis. However, a biopsy of the terminal ileum has the highest diagnostic yield in patients with known or suspected Crohn’s disease, terminal ileal abnormalities on imaging, or endoscopic findings of ulcers, ileitis, or erosions [66].

Colonoscopy is not routinely used to evaluate acute diarrhea because it is commonly due to infectious etiology. If stool tests are negative and/or if diarrhea persists, then endoscopy is indicated. An additional important exception is the case of an immunocompromised patient. In a patient with diarrhea with HIV, organ or bone marrow transplant, or on immunosuppressive medications, a colonoscopy with biopsy is necessary to exclude CMV colitis and graft versus host disease (GVHD). In such cases, colonoscopic evaluation of diarrhea has higher sensitivity and cost-effectiveness than FSIG [67]. Patients who undergo stem cell transplant often present with diarrhea in the initial 3 months following transplantation. In these patients, abnormal mucosa on endoscopy has not been shown to correlate with biopsy results. Therefore, biopsies of normal and abnormal-appearing mucosa are indicated, especially of the distal colon, which has the highest diagnostic yield in patients undergoing endoscopy for gastrointestinal symptoms [68]. Based on the location of highest diagnostic yield, a flexible sigmoidoscopy with distal colon biopsy is indicated in patients with diarrhea suspected of acute GVHD. However, some centers endorse combined upper GI endoscopy as well as colonoscopy in patients following hematopoietic stem cell transplantation to diagnose disease more quickly.

2.4. Therapeutic indications for colonoscopy

2.4.1. Excision and ablation of lesions

Endoscopic mucosal resection (EMR) is a method for treating early CRC. Most adenomas and intramucosal cancers can be removed by EMR. For tumors larger than 2 cm, EMR is less likely to achieve complete resection (histopathologically tumor-free lateral and vertical margins of the resected specimens) [69, 70]. Another method, known as endoscopic submucosal dissection (ESD) is also performed in several countries. The procedure is simpler than the laparoscopic colectomy but is time-consuming and carries a higher risk of perforation than EMR. ESD is indicated in lesions >2 cm, lesions that are suspected to be invasive submucosal cancer, and mucosal lesions with fibrosis or local residual early cancer after endoscopic resection. The rate of complete resection for large colorectal tumors by ESD has been reported to be 80-98.9% [71-74]. However, both procedures are operator-dependent and have limited data supporting their use.

2.4.2. Treatment of lower GI bleeding

Treatment of acute lower GI bleeding from any sources described earlier is indicated either urgently or as an elective procedure. In case of urgent colonoscopy, the colon is prepared using polyethylene glycol based solution administered orally or via nasogastric tube. Currently, metallic clip placement, thermal coagulation, and epinephrine injection are the available methods. Depending on the lesion and the severity of bleeding, colonoscopic intervention with any one of these methods is indicated as the first step in achieving hemostasis. In case of persistent diverticular bleeding, a bleeding vessel can be treated with metallic clip placement [75, 76]. Vascular ectasias can be treated with either thermal or epinephrine injection, though thermal cauterization has 87% of success rate [77]. Cases where a definite bleeding site cannot be located or cases where the visualization of the bleeding source is poor due to inadequate views due to bleeding need referral for angiographic or surgical treatment.

2.4.3. Colonic decompression

Acute colonic obstruction is a common presentation of colon cancer and, often, the presenting patient is in poor overall health making surgical intervention a suboptimal choice. Since 1990, the utility of colonoscopic interventions via either self-expanding metal stent (SEMS), placement of a decompression tube, or tumor debulking has become very popular and has been studied more frequently in recent years in various populations. Endoscopic interventions serve as a bridge to surgery or as a palliative measure in patients who are poor surgical candidates. A majority of the studies comparing SEMS placement with surgery has reported high clinical success rates (92%), better symptomatic relief, lower complication rates (<5%), cost-effectiveness, and higher patient acceptance and shorter hospital stay with endoscopic SEMS placement [78-83]. Argon plasma coagulation (APC) and snare polypectomy have been used to treat colonic obstruction and maintain luminal patency, and are good alternatives to endoscopic SEMS in treating colonic obstruction [84-86].

Endoscopic decompression of an acute colonic pseudo-obstruction or Ogilvie syndrome is another therapeutic indication for colonoscopy. The etiology of this condition is multifactorial (post-intraabdominal surgery, sepsis, hypothyroidism, neurological disorder, spinal cord injury, etc.) in the absence of a true mechanical obstruction. Bowel ischemia and perforation are dreaded complications and management is often conservative, involving the correction of the underlying disorder. However, in cases where the initial management fails, colonoscopic decompression is indicated [87, 88].

Colonoscopy is also used for decompression of sigmoid and cecal volvulus. Volvulus is a condition in which a part of colon twists upon itself. Due to venous congestion and obstruction to blood flow, tissue viability becomes a major issue. Patients presenting with signs of perforation, peritonitis, bowel necrosis or profound hemodynamic instability need immediate surgery. However, patients with less severe sigmoid and cecal volvulus can be managed endoscopically [89, 90]. Endoscopic correction of sigmoid volvulus achieves better success rates than the correction of cecal volvulus and is associated with a lesser need for surgical intervention [91]. A study by Oren and colleagues reported that sigmoidoscopic correction of sigmoid volvulus with a rectal tube was successful in 78% of patients [92]. Nevertheless, the rate of recurrence of sigmoid volvulus is high, ultimately requiring surgical treatment [93]. Cecal volvulus has been treated endoscopically but due to the high failure rate, often requires surgical intervention for most patients. Surgeons usually combine operative detorsion of cecal volvulus with right hemicolectomy (to prevent recurrence) and either a primary anastomosis or an ileostomy with mucus fistula. In medically unstable, high-risk patients who are poor surgical candidates or have poor vascular supplies to the cecum, cecal volvulus detorsion may be achieved with a cecostomy and cecopexy, which also are associated with significant morbidity and mortality [94]. Colonic volvuluses in other areas such as flexural territories are less common and the indication to perform colonoscopic interventions in these situations is not well studied.

2.4.4. Dilation of colonic stenosis

Colonoscopic intervention of stenotic lesions such as anastomotic strictures and strictures caused by IBD are among the common indications for performing colonoscopy. Several studies have reported high success rate with a low complications rate. However, recurrence is common. The methods commonly employed for the treatment of colonic stenosis are balloon dilation with or without steroid injection and electro-incision, all of which have been shown to have a variable amount of success [95-101].

2.4.5. Foreign body removal

The current management of the foreign bodies lying in the lower GI tract is based on the type of foreign body, the proximity to the anus, the injury to the adjacent structure, as well as the surgical and endoscopic expertise at the health care center. A foreign body in the GI tract presents after voluntary or involuntary insertion or ingestion of the foreign body. Very often, the patient tries to manipulate the object and attempts self-exploration to remove it before presenting to the hospital. Endoscopy provides an opportunity to avoid abdominal exploration. However if the radiological exam or clinical presentation indicates perforation or higher-lying object(s), colonoscopy may fail and may pose a delay in surgical management [102-106].

2.5. Miscellaneous indications

2.5.1. Abnormal radiological examination

Colonoscopy is commonly performed after an abnormal or suspicious radiological finding in the search for true pathological lesions such as cancers or ulcerative lesions. Filling defect or mucosal defect on barium enema or a luminal narrowing on barium enema or CT scan is routinely evaluated with a colonoscopy. Patients presenting with symptoms suggestive of acute diverticulitis with supportive CT scan findings also need to be evaluated with colonoscopy, but only after the acute inflammation has resolved. Air insufflation during colonoscopy in acute diverticulitis can lead to the bowel perforation and is considered a contraindication. A luminal defect or polyp(s) on CT scan or CT colonography is usually followed-up by a colonoscopy when feasible. However, controversy exists between the American College of Radiology, the American Gastroenterology Association, and American College of Gastroenterology regarding the size and number of polyps on CT colonography that meet the requirement for colonoscopy [107-109]. Patients with abnormal positron emission tomography (PET) scan showing a possible colorectal lesion should undergo colonoscopic evaluation. Nevertheless, in the light of insufficient clinical data, the indications for colonoscopy after abnormal radiological exam are based on individual presentation, availability of the endoscopist, age, and other comorbidities of the patient.

2.5.2. Isolated unexplained abdominal pain

Patients presenting with symptoms of chronic (>3 months) abdominal pain and nonspecific abdominal discomfort might require colonoscopy. In the era of thorough radiologic studies, the need for colonoscopy emerges after noninvasive diagnostic modalities fail and symptoms persist. There is no clear indication for performing colonoscopy in patients presenting with unexplained abdominal pain or discomfort. A detailed history and physical examination provide diagnostic clues but a diagnostic workup often ends up requiring colonoscopy. The diagnostic yield of colonoscopy has been previously studied in retrospective studies. For example, in a study by Neugut et al., a total of 7% of patients who presented with abdominal pain (n=113) either had carcinoma or a polyp >1 cm in size on colonoscopy [110]. It is worth mentioning that detection of the pathological process does not offer symptomatic relief in these cases. In a more recent study by Kueh and colleagues, the diagnostic yield of colonoscopy was evaluated from 2005 to 2010 in a tertiary center in New Zealand among the patients who presented with isolated abdominal pain, which accounted for 1.2% of all colonoscopies (n=2633). The diagnostic yield of colonoscopy for a cancer, adenoma, diverticulosis, or hemorrhoid in the patients with abdominal pain was significantly lower in this cohort than the yield of colonoscopy performed for other symptoms such as rectal bleeding and/or iron deficiency anemia [111].

2.5.3. Chronic constipation

Chronic constipation, as defined by the Rome III criteria [112], is reported to be associated with an increased risk of colon cancer in retrospective studies from the United States [113, 114], Australia [115], and Japan [116]. In contrast, no such association was found in several other studies [117-119]. Interestingly, the yield of colon cancer in colonoscopy performed for constipation alone was lower than in colonoscopy performed for routine colorectal cancer screening [120]. Patients with chronic constipation who present with alarming symptoms such as rectal bleeding, melena, iron-deficiency anemia, unintentional weight loss, or are >50 years should be evaluated with a colonoscopy to identify the etiology of the obstruction, such as cancer, stricture, or extrinsic compression. Colonoscopy can be used to treat chronic constipation based on the etiology. In patients who have undergone prior abdominal surgery, have inflammatory bowel disease, or are prone to ischemia, colonoscopy is used to dilate fibrotic strictures that lead to constipation [121-123]. Patients suffering from chronic constipation due to neurogenic bowel or acute colonic pseudo-obstruction also benefit from a percutaneous endoscopic colostomy [124]. Importantly, chronic constipation as a procedural indication for colonoscopy is independently associated with poor colon preparation requiring a rigorous amount of laxative(s) or a longer duration of preparation [125, 126].

2.5.4. Preoperative and intraoperative localization of colonic lesions

Colonic lesions, depending on the size and consistency, may pose some difficulty in localization by surgeons during the surgical procedure, and this could be even more difficult for laparoscopic surgeries than for open procedures. In such cases, localization of a mass or polyp of interest is very important. Preoperative colonoscopy to localize the lesion using penetrating India ink, Spot, or indocyanine green is becoming a common practice [127, 128]. The dye migrates to the peritoneal surface and allows for accurate localization. An alternative colonoscopic method of applying clips around the area of interest has also been studied, which requires intraoperative ultrasound to precisely locate the site. Both methods have their own advantages and disadvantages, such as inflammatory reaction to the dye, micro-abscesses, broad spreading of the dye in the field in smaller lesions, migration of the metallic clips, false localization, or inadvertent injection of dye in the adjacent vital structures. A recent review reported that the accuracy of endoscopic tattooing is 70-100% and the incidence of intraoperative invisible lesions is 1.6-15% [129]. The complications reviewed were mostly related to transmural injection and the spillage rates varied from 2.4 to 13% and were asymptomatic. Intraoperative colonoscopy can also be performed to localize the site of a tumor or a polypectomy site. However, intraoperative colonoscopy is an understudied field and has reported problems with insufflated air in the colon which interferes with the surgical technique.

3. Contraindications for colonoscopy (table 2)

A patient who is either unwilling to give informed consent, or has given informed consent but is uncooperative and/or unable to achieve adequate sedation for colonoscopy, should not undergo colonoscopy. Colonoscopy is also contraindicated for known or suspected colonic perforation. Medical conditions associated with a high risk of perforation such as severe toxic megacolon and fulminant colitis are considered contraindications to colonoscopy. Although not strictly contraindicated, severe IBD with deep ulceration in the rectum/distal sigmoid colon and acute diverticulitis increase the risk of colonic perforation. The risk factors for colonic perforation during colonoscopy are age > 65, low body mass index, female gender, hypoalbuminemia, inpatient status, critically ill condition, multiple morbidities, IBD, and other forms of colitis such as ischemic colitis, colonic stricture dilation, polypectomy, foreign body removal, and hemostasis such as cautery [130-132].

Patients who are or are suspected of becoming hemodynamically unstable should be medically stabilized before colonoscopy. In patients who have had a myocardial infarction, a colonoscopy performed in the first 3 weeks following the infarction can provoke an arrhythmia although the only reported complications during colonoscopy in the 30 days following an myocardial infarction are hypotension and bradycardia [133]. Adequate bowel preparation is necessary because inadequate or poor bowel preparation increases colonoscopy duration with an increase in complications as well as an increase in the number of missed adenomas and high-risk lesions [134].

Contraindications for colonoscopy:
1. Patient refusal
2. Uncooperative patients
3. Inadequate sedation
4. Known or suspected colonic perforation
5. Severe toxic megacolon and fulminant colitis
6. Clinically unstable patients
7. Recent myocardial infarction
8. Inadequate bowel preparation
9. Peritonism

Table 2.

Contraindications for colonoscopy

Patients with severe abdominal pain and peritoneal signs may be at risk for possible complete obstruction or gangrenous bowel and should be evaluated by other modalities first. These patients should not undergo colonoscopy due to the risk of bowel perforation from air insufflation of a distended bowel [135]. Colonoscopic decompression of cecal volvulus, though reported, has a high failure rate. Therefore, cecal volvulus should be managed surgically [94]. Failure of endoscopic bowel detorsion, or colonic volvulus with bowel perforation, bowel infarction, or peritonitis are indications for emergent surgery [135].

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Jigar Bhagatwala, Arpit Singhal, Summer Aldrugh, Muhammed Sherid, Humberto Sifuentes and Subbaramiah Sridhar (December 2nd 2015). Colonoscopy — Indications and Contraindications, Screening for Colorectal Cancer with Colonoscopy, Rajunor Ettarh, IntechOpen, DOI: 10.5772/61097. Available from:

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