Open access peer-reviewed Edited Volume

Renin-Angiotensin System

Past, Present and Future

Edited by Anna Tolekova

Trakia University, Bulgaria

Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system.

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Renin-Angiotensin SystemPast, Present and FutureEdited by Anna Tolekova

Published: July 12th 2017

DOI: 10.5772/63179

ISBN: 978-953-51-3352-0

Print ISBN: 978-953-51-3351-3

eBook (PDF) ISBN: 978-953-51-4748-0

Copyright year: 2017

Books open for chapter submissions

10708 Total Chapter Downloads

5 Crossref Citations

4 Web of Science Citations

17 Dimensions Citations


Open access peer-reviewed

1. The Angiotensin Affair: How Great Minds Thinking Alike Came to a Historical Agreement

By Matilde Otero‐Losada, Mariana H. Nobile and José Milei


Open access peer-reviewed

2. Involvement of the Renin‐Angiotensin System in Atherosclerosis

By Ana Kolakovic, Maja Zivkovic and Aleksandra Stankovic


Open access peer-reviewed

3. RAAS Blockade as First-Line Antihypertensive Therapy among People with CKD

By Panagiotis I. Georgianos, Elias V. Balaskas and Pantelis E. Zebekakis


Open access peer-reviewed

4. Signaling Pathways of Cardiac Remodeling Related to Angiotensin II

By Carolina Baraldi Araujo Restini, Arthur F. Engracia Garcia, Henrique Melo Natalin, Guilherme Melo Natalin and Elen Rizzi


Open access peer-reviewed

5. Renin-Angiotensin System on Reproductive Biology

By Anthony C.S. Castilho, Patrícia K. Fontes, Fernanda F. Franchi, Priscila H. Santos and Eduardo M. Razza


Open access peer-reviewed

6. Role of the Renin-Angiotensin System in Healthy and Pathological Pregnancies

By Émilie Pepin, Shahin Shabanipour Dehboneh, Nozha Raguema, Maedeh Talebi Esfandarani and Julie L. Lavoie


Open access peer-reviewed

7. The Role of Renin-Angiotensin System in Ocular Inflammation and Uveitis

By Ozlem Sahin and Alireza Ziaei


Open access peer-reviewed

8. Regulation of the Renin-Angiotensin-Aldosterone System by Reactive Oxygen Species

By Manuela Morato, Marta Reina-Couto, Dora Pinho, António Albino- Teixeira and Teresa Sousa


Open access peer-reviewed

9. Current Research of the Renin-Angiotensin System Effect on Stem Cell Therapy

By Elham Ahmadian, Aziz Eftekhari and Ahmad Yari Khosroushahi


Open access peer-reviewed

10. Renin-Angiotensin System MicroRNAs, Special Focus on the Brain

By Jose Gerardo-Aviles, Shelley Allen and Patrick Gavin Kehoe


Open access peer-reviewed

11. Renin-Angiotensin System and Renal Allograft Long-Term Outcome: A Review

By Rosa M. Viero and Luis Gustavo Modelli de Andrade


Open access peer-reviewed

12. Local Renin-Angiotensin System at Liver and Crosstalk with Hepatic Diseases

By Eylem Taskin and Celal Guven


Open access peer-reviewed

13. The Function of Renin and the Role of Food-Derived Peptides as Direct Renin Inhibitors

By Anne Pihlanto and Sari Mäkinen


Edited Volume and chapters are indexed in

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  • CNKI

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