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Engineering » Biomedical Engineering » "Biosensors for Health, Environment and Biosecurity", book edited by Pier Andrea Serra, ISBN 978-953-307-443-6, Published: July 19, 2011 under CC BY-NC-SA 3.0 license. © The Author(s).

Chapter 7

Label-free Biosensors for Health Applications

By Cai Qi, George F. Gao and Gang Jin
DOI: 10.5772/17103

  1. Y. J. Bai, J. R. Zhao, G. T. Lv, W. H. Zhang, Y. Wang, X. J. Yan, 2003 Rapid and high throughput detection of HBV YMDD mutants with fluorescence polarization. World J Gastroenterol 9 10 2344 2347 .

  2. S. K. Bhatia, L. C. Shriver-Lake, K. J. Prior, J. H. Georger, J. M. Calvert, R. Bredehorst, F. S. Ligler, 1989 Use of thiol-terminal silanes and heterobifunctional crosslinkers for immobilization of antibodies on silica surfaces. Anal Biochem 178 2 408 413 .

  3. Y. Chen, W. Wu, L. J. Li, B. Lou, J. Zhang, J. Fan, 2006 Comparison of the results for three automated immunoassay systems in determining serum HBV markers. Clin Chim Acta 372(1-2): 129 EOF -133.

  4. M. S. De Mitri, R. Cassini, M. Bernardi, 2010 Hepatitis B virus-related hepatocarcinogenesis: molecular oncogenic potential of clear or occult infections. Eur J Cancer 46 12 2178 2186 .

  5. N. S. El Saghir, C. A. Adebamowo, B. O. Anderson, R. W. Carlson, P. A. Bird, M. Corbex, R. A. Badwe, M. A. Bushnaq, A. Eniu, J. R. Gralow, J. K. Harness, R. Masetti, F. Perry, M. Samiei, D. B. Thomas, B. Wiafe-Addai, E. Cazap, 2011 Breast cancer management in low resource countries (LRCs): Consensus statement from the Health Global Initiative. Breast. Pressing

  6. Y. Feng, G. F. Gao, 2007 Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus. Comp Immunol Microbiol Infect Dis 30(5-6): 309 EOF 327 EOF .

  7. J. Ferlay, H. R. Shin, F. Bray, D. Forman, C. Mathers, D. M. Parkin, 2010 Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127 12 2893 2917

  8. B. Friguet, A. F. Chaffotte, L. Djavadi-Ohaniance, M. E. Goldberg, 1985 Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay. J Immunol Methods 77 2 305 19 .

  9. B. Guezguez, P. Vigneron, N. Lamerant, C. Kieda, T. Jaffredo, D. Dunon, 2007 Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor. J Immunol 179 10 6673 6685 .

  10. K. Hall, M. I. Aguilar, 2010 Surface plasmon resonance spectroscopy for studying the membrane binding of antimicrobial peptides. Methods Mol Biol 627 2 13 23 .

  11. J. A. Handley, B. J. Mc Neil, 1982 The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143 1 29 36 .

  12. R. Jahn, R. H. Scheller, 2006 SNAREs--engines for membrane fusion. Nat Rev Mol Cell Biol 7 9 631 43 .

  13. G. Jin, P. Tengvall, I. Lundstrom, H. Arwin, 1995 Abiosensor concept based on imaging ellipsometry for visualization of biomolecular interactions. Anal Biochem 232 1 69 72 .

  14. G. Jin, R. Jansson, H. Arwin, 1996 Imaging ellipsometry revisited: developments for visualization of thin transparent layers on silicon substrates. Rev Sci Instrum 67 8 2930 2936 .

  15. G. Jin, Z. H. Wang, C. Qi, Z. Y. Zhao, S. Chen, Y. H. Meng, P. Q. Ying, L. H. Xia, L. J. Wan, 2003 Immune-microassay with optical proteinchip for protein detection. Proceedings of the 25th annual international conference of the IEEE EMBS, Cancun Mexico, 3575 3577 . Sep 17-21, 2003.

  16. G. Jin, Z. Y. Zhao, Z. H. Wang, Y. H. Meng, P. Q. Ying, S. Chen, Y. Y. Chen, C. Qi, L. H. Xia, 2004 The development of biosensor with imaging ellipsometry. Proceedings of 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 0589-1019 San Francisco, CA, United states. September 1 5 .

  17. G. Jin, 2008 Development of biosensor based on imaging ellipsometry. Phys Stat Sol 205 4 810 816 .

  18. G. Jin, Y. H. Meng, L. Liu, Y. Niu, S. Chen, Q. Cai, T. J. Jiang, 2011 Development of biosensor based on imaging ellipsometry and biomedical applications. Thin Solid Films 519 9 2750 2757 .

  19. I. Langmuir, V. J. Schaefer, 1936 Optical measurements of the thickness of a film adsorbed from a solution. J Am Chem Soc 59: 1406

  20. A. L. Li, H. W. Li, J. Zhang, R. J. Xiu, 2004 Initial Study on Thymidine Phosphorylase in Breast Cancer Tissue by Optical Protein Chip. J of Chinese Microcirculation 8 4 257 260 .

  21. A. C. Malmborg, A. Michaëlsson, M. Ohlin, B. Jansson, C. A. Borrebaeck, 1992 Real time analysis of antibody-antigen reaction kinetics. Scand J Immunol 35 6 643 650 .

  22. Y. Niu, J. Zhuang, L. Liu, X. Y. Yan, G. Jin, 2011 Two kinds of anti-ricin antibody and ricin interaction evaluated by biosensor based on imaging ellipsometry. Thin Solid Films 519 9 2768 2771 .

  23. S.M. Poutanen, D.E. Low, B. Henry, S. Finkelstein, D. Rose, K Green, R. Tellier, R. Draker, D. Adachi, M. Ayers, A.K. Chan, D.M. Skowronski, I. Salit, A.E. Simor, A.S. Slutsky, P.W. Doyle, M. Krajden, M. Petric, R.C. Brunham, A.J. McGeer, National Microbiology Laboratory, Canada.& Canadian Severe Acute Respiratory Syndrome Study Team. (2003).Identification of severe acute respiratory syndrome in Canada. N Engl J Med 348(20):1995-2005.

  24. C. Qi, J. Z. Duan, Z. H. Wang, et al. 2006a Investigation of interaction between two neutralizing monoclonal antibodies and SARS virus using biosensor based on imaging ellipsometry. Biomed Microdevices 8 3 247 253 .

  25. C. Qi, R. Q. Hao, G. Jin, 2006b Detection Alzheimer’s disease (AD) tau protein using protein chip biosensor. Acta Biophysica Sinica 22: 17

  26. C. Qi, W. Zhu, Y. Niu, H. G. Zhang, G. Y. Zhu, Y. H. Meng, S. Chen, G. Jin, 2009a Clinical HBV markers detection with biosensor based on imaging ellipsometry. J Viral Hepat 16 11 822 832 .

  27. C. Qi, Y. Lin, J. Feng, Z. H. Wang, C. F. Zhu, Y. H. Meng, X. Y. Yan, L. J. Wan, G. Jin, 2009b Phage M13KO7 detection with biosensor based on imaging ellipsometry and AFM microscopic confirmation. Virus Res 140(1-2): 79 EOF 84 EOF -86.

  28. M. Schena, 2005 Protein microarrays. Jones and Bartlett Publishers,Inc. 0-76373-127-7

  29. Z. Sun, L. Ming, X. Zhu, J. Lu, 2002 Prevention and control of hepatitis B in China. J Med Virol 67 3 447 450 .

  30. R. A. Vijayendran, D. E. Leckband, 2001 A quantitative assessment of heterogeneity for surface- immobilized proteins. Anal Chem 73 3 471 480 .

  31. C. L. Wang, J. Q. Li, H. W. Li, G. Jin, Z. H. Wang, Y. H. Meng, R. J. Xiu, 2009 Soluble angiopoietin receptor Tie-2 in patients with acute myocardial infarction and its detection by optical protein-chip. Artif Cells Blood Substit Immobil Biotechnol 37 4 183 186 .

  32. Z. H. Wang, G. Jin, 2003b A label-free multisensing immunosensor based on imaging ellipsometry. Anal chem 75 22 6119 6123 .

  33. Z. H. Wang, G. Jin, 2003a Feasibility of protein A for the oriented immobilization of immunoglobulin on silicon surface for a biosensor with imaging ellipsometry. J Biochem Biophys Methods 57 3 203 211 .

  34. Z. H. Wang, G. Jin, 2004 Covalent immobilization of proteins for the biosensor based on imaging ellipsometry. J Immunol Meth 285 2 237 243 .

  35. Z. H. Wang, Y. H. Meng, P. Ying, C. Qi, G. Jin, 2006 A label-free protein microfluidic array for parallel immunoassays. Electrophoresis 27 20 4078 4085 .

  36. World Health Organization [WHO]. 2011 Available from: March 2011.

  37. X. Yan, Y. Lin, D. Yang, et al. 2003 A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth. Blood 102 1 184 191 .

  38. H. Zhang, J. Chen, Y. Wang, L. Peng, X. Dong, Y. Lu, A. E. Keating, T. Jiang, 2009 A computationally guided protein-interaction screen uncovers coiled-coil interactions involved in vesicular trafficking. J Mol Biol 392 1 228 241 .

  39. H. G. Zhang, Cai. Qi, Z. H. Wang, G. Jin, R. J. Xiu, 2005 Evaluation of a New CA15-3 Protein Assay Method: Optical Protein-Chip System for Clinical Application. Clinical Chemistry 51 6 1038 1040 .

  40. W. Zhu, H. L. Sun, G. Jin, C. Qi, Z. Y. Zhao, 2007 Study on ellipsometry-imaging protein-chip for CRP quantitative detection. lnt J Lab Med 28 7 577 582 .

  41. C. Qi, X.S. Tian, S. Chen, J.H. Yan, Z. Cao, K.G. Tian, G.F. Gao, G. Jin, 2010 Detection of avian influenza virus subtype H5 using a biosensor based on imaging ellipsometry. Biosens Bioelectron 25(6: 1530-1534.