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Medicine » Cardiology and Cardiovascular Medicine » "Artery Bypass", book edited by Wilbert S. Aronow, ISBN 978-953-51-1025-5, Published: March 13, 2013 under CC BY 3.0 license. © The Author(s).

Chapter 15

Pharmacology of Arterial Grafts for Coronary Artery Bypass Surgery

By Oguzhan Yildiz, Melik Seyrek and Husamettin Gul
DOI: 10.5772/54723

  1. Sarabu MR, McClung JA, Fass A, Reed GE. Early postoperative spasm in left internal mammary artery bypass grafts. Ann Thorac Surg. 1987;44(2):199-200.

  2. Houghton JL, Callaghan WE, Frank MJ. Disappearance of high-grade left anterior descending stenosis after revascularization. Cathet Cardiovasc Diagn. 1988;14(3):169-171.

  3. McCormick JR, Kaneko M, Baue AE, Geha AS. Blood flow and vasoactive drug effects in internal mammary and venous bypass grafts. Circulation. 1975;52(2):72-80.

  4. Jett GK, Arcidi JM Jr, Dorsey LM, Hatcher CR Jr, Guyton RA. Vasoactive drug effects on blood flow in internal mammary artery and saphenous vein grafts. J Thorac Cardiovasc Surg. 1987;94(1):2-11.

  5. Kawasuji M, Tedoriya T, Takemura H, Sakakibara N, Taki J, Watanabe Y. Flow capacities of arterial grafts for coronary artery bypass grafting. Ann Thorac Surg. 1993;56(4):957-962.

  6. Loop FD, Thomas JD. Hypoperfusion after arterial bypass grafting. Ann Thorac Surg. 1993;56(4):812-813.

  7. Suma H. Spasm of the gastroepiploic artery graft. Ann Thorac Surg. 1990;49(1):168-169.

  8. Fisk RL, Brooks CH, Callaghan JC, Dvorkin J. Experience with the radial artery graft for coronary artery bypass. Ann Thorac Surg. 1976;21(6):513-518.

  9. Mills NL, Bringaze WL 3rd. Preparation of the internal mammary artery graft. Which is the best method? J Thorac Cardiovasc Surg. 1989;98(1):73-77.

  10. He GW, Angus JA, Rosenfeldt FL. Reactivity of the canine isolated internal mammary artery, saphenous vein, and coronary artery to constrictor and dilator substances: relevance to coronary bypass graft surgery. J Cardiovasc Pharmacol. 1988;12(1):12-22.

  11. Rosenfeldt FL, He GW, Buxton BF, Angus JA. Pharmacology of coronary artery bypass grafts. Ann Thorac Surg. 1999;67(3):878-888. Review.

  12. He GW, Yang CQ. Pharmacological studies and guidelines for the use of vasodilators for arterial grafts. In He GW (ed.) Arterial grafting for coronary artery bypass surgery. Springer; 2006. p38-47.

  13. He GW, Yang CQ, Starr A. Overview of the nature of vasoconstriction in arterial grafts for coronary operations. Ann Thorac Surg. 1995;59(3):676-683

  14. Angus JA, Cocks TM, Satoh K. Alpha 2-adrenoceptors and endothelium-dependent relaxation in canine large arteries. Br J Pharmacol. 1986;88(4):767-777.

  15. Dignan RJ, Yeh T Jr, Dyke CM, Lee KF, Lutz HA 3rd, Ding M, Wechsler AS. Reactivity of gastroepiploic and internal mammary arteries. Relevance to coronary artery bypass grafting. J Thorac Cardiovasc Surg. 1992;103(1):116-122.

  16. Chardigny C, Jebara VA, Acar C, Descombes JJ, Verbeuren TJ, Carpentier A, Fabiani JN. Vasoreactivity of the radial artery. Comparison with the internal mammary and gastroepiploic arteries with implications for coronary artery surgery. Circulation. 1993;88:115-127.

  17. He G-W, Yang C-Q, Acuff TE, Ryan WH, Mack MJ. Endothelium-derived hyperpolarizing factor (EDHF) plays a role in human coronary bypass grafts through Na+-K+ pump mechanism [Abstract]. Circulation 1994;90:242.

  18. Henry PJ, Drummer OH, Horowitz JD. S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators. Br J Pharmacol. 1989;98(3):757-766.

  19. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA. 1987;84(24):9265-9269.

  20. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327(6122):524-526.

  21. Moncada S, Korbut R, Bunting S, Vane JR. Prostacyclin is a circulating hormone. Nature. 1978;273(5665):767-768.

  22. Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol. 1988;93(3):515-524.

  23. Chen G, Suzuki H, Weston AH. Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br J Pharmacol. 1988;95(4):1165-1174.

  24. He GW, Yang CQ, Graier WF, Yang JA. Hyperkalemia alters EDHF-mediated hyperpolarization and relaxation in coronary arteries. Am J Physiol. 1996;271:H760-767.

  25. Ge ZD, Zhang XH, Fung PC, He GW. Endothelium-dependent hyperpolarization and relaxation resistance to N(G)-nitro-L-arginine and indomethacin in coronary circulation. Cardiovasc Res. 2000;46(3):547-556.

  26. Schoeffter P, Dion R, Godfraind T. Modulatory role of the vascular endothelium in the contractility of human isolated internal mammary artery. Br J Pharmacol 1988;95:531-543.

  27. Acar C, Jebara VA, Portoghese M, Beyssen B, Pagny JY, Grare P, Chachques JC, Fabiani JN, Deloche A, Guermonprez JL. Revival of the radial artery for coronary artery bypass grafting. Ann Thorac Surg. 1992;54(4):652-659.

  28. van Zwienen JCW, van der Linden CJ, Cimbrere JSF, Lacquet LK, Booij LHDJ, Hendriks T. Endothelin release during coronary artery bypass grafting [Abstract]. Chest 1993;103:176S

  29. Davies GC, Sobel M, Salzman EW. Elevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass. Circulation. 1980;61(4):808-814.

  30. He GW, Shaw J, Hughes CF, Yang CQ, Thomson DS, McCaughan B, Hendle PN, Baird DK. Predominant alpha 1-adrenoceptor-mediated contraction in the human internal mammary artery. J Cardiovasc Pharmacol. 1993;21(2):256-263.

  31. He GW, Buxton B, Rosenfeldt FL, Wilson AC, Angus JA. Weak beta-adrenoceptor-mediated relaxation in the human internal mammary artery. J Thorac Cardiovasc Surg. 1989;97(2):259-266.

  32. Seo B, Oemar BS, Siebenmann R, von Segesser L, Lüscher TF. Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels. Circulation. 1994;89(3):1203-1208.

  33. Yildiz O, Ciçek S, Ay I, Tatar H, Tuncer M. 5-HT1-like receptor-mediated contraction in the human internal mammary artery. J Cardiovasc Pharmacol. 1996;28(1):6-10.

  34. He GW, Yang CQ. Comparison of nitroprusside and nitroglycerin in inhibition of angiotensin II and other vasoconstrictor-mediated contraction in human coronary bypass conduits. Br J Clin Pharmacol. 1997;44(4):361-367.

  35. He GW, Yang CQ. Effect of thromboxane A2 antagonist GR32191B on prostanoid and nonprostanoid receptors in the human internal mammary artery. J Cardiovasc Pharmacol. 1995;26(1):13-19.

  36. He GW, Yang Q, Yang CQ. Smooth muscle and endothelial function of arterial grafts for coronary artery bypass surgery. Clin Exp Pharmacol Physiol. 2002;29(8):717-720. Review.

  37. Liu JJ, Phillips PA, Burrell LM, Buxton BB, Johnston CI. Human internal mammary artery responses to non-peptide vasopressin antagonists. Clin Exp Pharmacol Physiol. 1994;21(2):121-124.

  38. Luu TN, Dashwood MR, Chester AH, Tadjkarimi S, Yacoub MH. Action of vasoactive intestinal peptide and distribution of its binding sites in vessels used for coronary artery bypass grafts. Am J Cardiol. 1993;71(15):1278-1282.

  39. Myers ML, Li GH, Yaghi A, McCormack D. Human internal thoracic artery reactivity to dopaminergic agents. Circulation. 1993;88[Part 2]:110-114.

  40. Cocks TM, Angus JA. Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature. 1983;305(5935):627-630.

  41. Schoeffter P, Hoyer D. 5-Hydroxytryptamine (5-HT)-induced endothelium-dependent relaxation of pig coronary arteries is mediated by 5-HT receptors similar to the 5-HT1D receptor subtype. J Pharmacol Exp Ther. 1990;252(1):387-395.

  42. He GW, Yang CQ. "Vasoactivators"--a new concept for naturally secreted vasoconstrictor substances. Angiology. 1994;45(4):265-271.

  43. Luscher TF, Diederich D, Siebenmann R, Lehmann K, Stulz P, von Segesser L, Yang ZH, Turina M, Grädel E, Weber E. Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N Engl J Med. 1988;319(8):462-467

  44. Liu MH, Jin H, Floten HS, Ren Z, Yim AP, He GW. Vascular endothelial growth factor-mediated, endothelium-dependent relaxation in human internal mammary artery. Ann Thorac Surg. 2002;73(3):819-824.

  45. Wei W, Jin H, Chen ZW, Zioncheck TF, Yim AP, He GW. Vascular endothelial growth factor-induced nitric oxide- and PGI2-dependent relaxation in human internal mammary arteries: a comparative study with KDR and Flt-1 selective mutants. J Cardiovasc Pharmacol. 2004;44(5):615-621.

  46. Liu ZG, Ge ZD, He GW. Difference in endothelium-derived hyperpolarizing factor-mediated hyperpolarization and nitric oxide release between human internal mammary artery and saphenous vein. Circulation. 2000;102(19 Suppl 3):296-301.

  47. He GW, Liu ZG. Comparison of nitric oxide release and endothelium-derived hyperpolarizing factor-mediated hyperpolarization between human radial and internal mammary arteries. Circulation. 2001;104(12 Suppl 1):344-349.

  48. He GW, Acuff TE, Ryan WH, Yang CQ, Mack MJ. Functional comparison between the human inferior epigastric artery and internal mammary artery. Similarities and differences. J Thorac Cardiovasc Surg. 1995;109(1):13-20.

  49. He GW, Yang CQ. Radial artery has higher receptor-mediated contractility but similar endothelial function compared with mammary artery. Ann Thorac Surg. 1997;63(5):1346-1352.

  50. Chen ZW, Huang Y, Yang Q, Li X, Wei W, He GW. Urocortin-induced relaxation in the human internal mammary artery. Cardiovasc Res. 2005;65(4):913-920.

  51. von Segesser L, Simonet F, Meier 8, Finci L, Faidutti B. Inadequate flow after internal mammaryxoronary artery anastomoses. Thorac Cardiovasc Surg 1987;35:352-354.

  52. von Segesser LK, Lehmann K, Turina M. Deleterious effects of shock in internal mammary artery anastomoses. Ann Thorac Surg. 1989;47(4):575-579.

  53. Huddleston CB, Stoney WS, Alford WC Jr, Burrus GR, Glassford DM Jr, Lea JW 4th, Petracek MR, Thomas CS Jr. Internal mammary artery grafts: technical factors influencing patency. Ann Thorac Surg. 1986;42(5):543-549.

  54. He GW, Rosenfeldt FL, Buxton BF, Angus JA. Reactivity of human isolated internal mammary artery to constrictor and dilator agents. Implications for treatment of internal mammary artery spasm. Circulation. 1989;80(3 Pt 1):I141-150.

  55. Cooper GJ, Wilkinson GA, Angelini GD. Overcoming perioperative spasm of the internal mammary artery: which is the best vasodilator? J Thorac Cardiovasc Surg. 1992;104(2):465-468.

  56. Dion RA, Verhelst R, Goenen M, Rousseau M, Baele P, Ponlot R, Schoevaerdts JC, Chalant CH. Sequential mammary artery grafts in one hundred and twenty consecutive patients: indications, operative technique, 6 months postoperative functional and angiographic controls. J Cardiovasc Surg (Torino). 1989;30(4):635-642.

  57. Dion R, Verhelst R, Rousseau M, Goenen M, Ponlot R, Kestens-Servaye Y, Chalant CH. Sequential mammary grafting. Clinical, functional, and angiographic assessment 6 months postoperatively in 231 consecutive patients. J Thorac Cardiovasc Surg. 1989;98(1):80-88.

  58. Galbut DL, Traad EA, Dorman MJ, DeWitt PL, Larsen PB, Kurlansky PA, Button JH, Ally JM, Gentsch TO. Seventeen-year experience with bilateral internal mammary artery grafts. Ann Thorac Surg. 1990;49(2):195-201.

  59. Eckel L, Skupin M, Schräder R, Gusic L, Beyersdorf F, Sarai K, Krause E. Adequate flow through the internal mammary artery graft achieved by a dilatation technique. Thorac Cardiovasc Surg. 1990;38(3):157-160.

  60. Green GE. Rate of blood flow from the internal mammary artery. Surgery. 1971;70(6):809-813.

  61. He GW, Rosenfeldt FL, Angus JA. Pharmacological relaxation of the saphenous vein during harvesting for coronary artery bypass grafting. Ann Thorac Surg. 1993;55(5):1210-1217.

  62. He GW, Yang CQ. Use of verapamil and nitroglycerin solution in preparation of radial artery for coronary grafting. Ann Thorac Surg. 1996;61(2):610-614.

  63. Martin W, Furchgott RF, Villani GM, Jothianandan D. Phosphodiesterase inhibitors induce endothelium-dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor. J Pharmacol Exp Ther. 1986;237(2):539-547.

  64. Huddart H, Saad KH. Papaverine-induced inhibition of electrical and mechanical activity and calcium movements of rat ileal smooth muscle. J Exp Biol. 1980;86:99-114.

  65. Fujioka M. Lack of a causal relationship between the vasodilator effect of papaverine and cyclic AMP production in the dog basilar artery. Br J Pharmacol. 1984;83(1):113-124.

  66. Brading AF, Burdyga TV, Scripnyuk ZD. The effects of papaverine on the electrical and mechanical activity of the guinea-pig ureter. J Physiol. 1983;334:79-89.

  67. Boerboom LE, Olinger GN, Bonchek LI, Gunay II, Kissebah AH, Rodriguez ER, Ferrans VJ. The relative influence of arterial pressure versus intraoperative distention on lipid accumulation in primate vein bypass grafts. J Thorac Cardiovasc Surg. 1985;90(5):756-764.

  68. Malone JM, Kischer CW, Moore WS. Changes in venous endothelial fibrinolytic activity and histology with in vitro venous distention and arterial implantation. Am J Surg. 1981;142(2):178-182.

  69. van Son JA, Tavilla G, Noyez L. Detrimental sequelae on the wall of the internal mammary artery caused by hydrostatic dilation with diluted papaverine solution. J Thorac Cardiovasc Surg. 1992;104(4):972-976.

  70. Constantinides P, Robinson M. Ultrastructural injury of arterial endothelium. 1. Effects of pH, osmolarity, anoxia, and temperature. Arch Pathol. 1969;88(2):99-105.

  71. Roberts AJ, Hay DA, Jawahar LM, et al. Biochemical and ultrastructural integrity of the saphenous vein conduit during CABG: preliminary results of the effect of papaverine. J Thorac Cardiovasc Surg 1984;88:39-48.

  72. He GW, Buxton BF, Rosenfeldt FL, Angus JA, Tatoulis J. Pharmacologic dilatation of the internal mammary artery during coronary bypass grafting. J Thorac Cardiovasc Surg. 1994;107(6):1440-1444.

  73. Cunningham JN Jr. Papaverine hydrochloride preservation of vein grafts. J Thorac Cardiovasc Surg. 1982;84(6):933.

  74. He GW, Yang CQ, Mack MJ, Acuff TE, Ryan WH, Starr A. Interaction between endothelin and vasodilators in the human internal mammary artery. Br J Clin Pharmacol. 1994;38(6):505-512.

  75. He GW, Shaw J, Yang CQ, Hughes C, Thomson D, McCaughan B, Hendle PN, Baird DK. Inhibitory effects of glyceryl trinitrate on alpha-adrenoceptor mediated contraction in the human internal mammary artery. Br J Clin Pharmacol. 1992;34(3):236-243.

  76. He GW, Yang CO, Gately H, Furnary A, Swanson J, Ahmad A, Floten S, Wood J, Starr A. Potential greater than additive vasorelaxant actions of milrinone and nitroglycerin on human conduit arteries. Br J Clin Pharmacol. 1996;41(2):101-107.

  77. He GW, Yang CQ. Comparison of the vasorelaxant effect of nitroprusside and nitroglycerin in the human radial artery in vitro. Br J Clin Pharmacol. 1999;48(1):99-104.

  78. Zabeeda D, Medalion B, Jackobshvilli S, Ezra S, Schachner A, Cohen AJ. Comparison of systemic vasodilators: effects on flow in internal mammary and radial arteries. Ann Thorac Surg. 2001;71(1):138-141.

  79. Shapira OM, Xu A, Vita JA, Aldea GS, Shah N, Shemin RJ, Keaney JF Jr. Nitroglycerin is superior to diltiazem as a coronary bypass conduit vasodilator. J Thorac Cardiovasc Surg. 1999;117(5):906-911.

  80. Shapira OM, Alkon JD, Macron DS, Keaney JF Jr, Vita JA, Aldea GS, Shemin RJ. Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm. Ann Thorac Surg. 2000;70(3):883-888.

  81. Chavanon O, Cracowski JL, Hacini R, Stanke F, Durand M, Noirclerc M, Blin D. Effect of topical vasodilators on gastroepiploic artery graft. Ann Thorac Surg. 1999;67(5):1295-1298

  82. Lobato EB, Janelle GM, Urdaneta F, Martin TD. Comparison of milrinone versus nitroglycerin, alone and in combination, on grafted internal mammary artery flow after cardiopulmonary bypass: effects of alpha-adrenergic stimulation. J Cardiothorac Vasc Anesth. 2001;15(6):723-727.

  83. Cable DG, Caccitolo JA, Pearson PJ, O'Brien T, Mullany CJ, Daly RC, Orszulak TA, Schaff HV. New approaches to prevention and treatment of radial artery graft vasospasm. Circulation. 1998;98(19 Suppl):II15-21.

  84. Beavo JA, Reifsnyder DH. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol Sci. 1990;11(4):150-155. Review.

  85. Beavo JA. Multiple isozymes of cyclic nucleotide phosphodiesterase. Adv Second Messenger Phosphoprotein Res. 1988;22:1-38. Review.

  86. He GW, Yang CQ. Inhibition of vasoconstriction by phosphodiesterase III inhibitor milrinone in human conduit arteries used as coronary bypass grafts. J Cardiovasc Pharmacol. 1996;28(2):208-214.

  87. Liu JJ, Doolan LA, Xie B, Chen JR, Buxton BF. Direct vasodilator effect of milrinone, an inotropic drug, on arterial coronary bypass grafts. J Thorac Cardiovasc Surg. 1997;113(1):108-113.

  88. He GW. Effect of milrinone on coronary artery bypass grafts. J Thorac Cardiovasc Surg. 1997;114(2):302-304.

  89. Yildiz O, Nacitarhan C, Seyrek M. Potassium channels in the vasodilating action of levosimendan on the human umbilical artery. J Soc Gynecol Investig. 2006;13(4):312-315.

  90. Yildiz O. Vasodilating mechanisms of levosimendan: involvement of K+ channels. J Pharmacol Sci. 2007;104(1):1-5.

  91. Yildiz O, Seyrek M, Yildirim V, Demirkilic U, Nacitarhan C. Potassium channel-related relaxation by levosimendan in the human internal mammary artery. Ann Thorac Surg. 2006;81(5):1715-1719.

  92. He GW, Acuff TE, Ryan WH, Yang CQ, Douthit MB, Bowman RT, Mack MJ. Inhibitory effects of calcium antagonists on alpha-adrenoceptor-mediated contraction in the human internal mammary artery. Br J Clin Pharmacol. 1994;37(2):173-179.

  93. Wei W, Floten HS, He GW. Interaction between vasodilators and vasopressin in internal mammary artery and clinical significance. Ann Thorac Surg. 2002;73(2):516-522.

  94. Atwal KS. Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers. J Cardiovasc Pharmacol. 1994;24 Suppl 4:S12-17. Review.

  95. Quast U, Guillon JM, Cavero I. Cellular pharmacology of potassium channel openers in vascular smooth muscle. Cardiovasc Res. 1994;28(6):805-810. Review.

  96. Lazdunski M, Allard B, Bernardi H, De Weille J, Fosset M, Heurteaux C, Honoré E. ATP-sensitive K+ channels. Ren Physiol Biochem. 1994;17(3-4):118-120.

  97. He GW, Yang CQ, Graier WF, Yang JA. Hyperkalemia alters EDHF-mediated hyperpolarization and relaxation in coronary arteries. Am J Physiol. 1996;271(2 Pt 2):760-767.

  98. He GW, Yang CQ. Superiority of hyperpolarizing to depolarizing cardioplegia in protection of coronary endothelial function. J Thorac Cardiovasc Surg. 1997;114(4):643-650.

  99. He GW. Potassium-channel opener in cardioplegia may restore coronary endothelial function. Ann Thorac Surg. 1998;66(4):1318-1322.

  100. Liu MH, Floten HS, Furnary AP, Yim AP, He GW. Effects of potassium channel opener aprikalim on the receptor-mediated vasoconstriction in the human internal mammary artery. Ann Thorac Surg. 2001;71(2):636-641.

  101. Ren Z, Floten S, Furnary A, Liu M, Gately H, Swanson J, Ahmad A, Yim AP, He GW. Effects of potassium channel opener KRN4884 on human conduit arteries used as coronary bypass grafts. Br J Clin Pharmacol. 2000;50(2):154-160.

  102. He GW, Yang CQ. Inhibition of vasoconstriction by potassium channel opener aprikalim in human conduit arteries used as bypass grafts. Br J Clin Pharmacol.1997;44(4):353-359.

  103. Yan M, Liu DL, Chua YL, Chen C, Lim YL. Tyrosine kinase inhibitors suppress alpha1-adrenoceptor mediated contraction in human radial, internal mammary arteries and saphenous vein. Neurosci Lett. 2002;333(3):171-174.

  104. Conant AR, Shackcloth MJ, Oo AY, Chester MR, Simpson AW, Dihmis WC. Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators. J Thorac Cardiovasc Surg. 2003;126(2):448-454.

  105. Shafiei M, Omrani G, Mahmoudian M. Coexistence of at least three distinct beta-adrenoceptors in human internal mammary artery. Acta Physiol Hung. 2000;87(3):275-286.

  106. Cracowski JL, Stanke-Labesque F, Chavanon O, Blin D, Mallion JM, Bessard G, Devillier P. Vasorelaxant actions of enoximone, dobutamine, and the combination on human arterial coronary bypass grafts. J Cardiovasc Pharmacol. 1999;34(5):741-748.

  107. Katai R, Tsuneyoshi I, Hamasaki J, Onomoto M, Suehiro S, Sakata R, Kanmura Y. The variable effects of dopamine among human isolated arteries commonly used for coronary bypass grafts. Anesth Analg. 2004;98(4):915-920, table of contents.

  108. Yildiz O, Ciçek S, Ay I, Demirkiliç U, Tuncer M. Hypertension increases the contractions to sumatriptan in the human internal mammary artery. Ann Thorac Surg. 1996;62(5):1392-1395.

  109. Yildiz O, Smith JR, Purdy RE. Serotonin and vasoconstrictor synergism. Life Sci. 1998;62(19):1723-1732. Review.

  110. Chen J, Yildiz O, Purdy RE. Phenylephrine precontraction increases the sensitivity of rabbit femoral artery to serotonin by enabling 5-HT1-like receptors. J Cardiovasc Pharmacol. 2000;35(6):863-870.

  111. Rego AC, Oliveira CR. Influence of lipid peroxidation on [3H]ketanserin binding to 5-HT2 prefrontal cortex receptors. Neurochem Int. 1995;27(6):489-496.

  112. Yildiz O, Seyrek M, Gul H, Un I, Yildirim V, Ozal E, Uzun M, Bolu E. Testosterone relaxes human internal mammary artery in vitro. J Cardiovasc Pharmacol. 2005;45(6):580-585.

  113. Yildiz O, Seyrek M, Un I, Gul H, Candemir G, Yildirim V. The relationship between risk factors and testosterone-induced relaxations in human internal mammary artery. J Cardiovasc Pharmacol. 2005;45(1):4-7.

  114. Seyrek M, Yildiz O, Ulusoy HB, Yildirim V. Testosterone relaxes isolated human radial artery by potassium channel opening action. J Pharmacol Sci. 2007;103(3):309-316.

  115. Yildiz O, Seyrek M. Vasodilating mechanisms of testosterone. Exp Clin Endocrinol Diabetes. 2007;115(1):1-6. Review.

  116. Irkilata HC, Yildiz O, Yildirim I, Seyrek M, Basal S, Dayanc M, Ulku C. The vasodilator effect of testosterone on the human internal spermatic vein and its relation to varicocele grade. J Urol. 2008;180(2):772-776.

  117. Seyrek M, Irkilata HC, Vural IM, Yildirim I, Basal S, Yildiz O, Dayanc M. Testosterone relaxes human internal spermatic vein through potassium channel opening action. Urology. 2011;78(1): 233.e1-5.

  118. Yildiz O, Seyrek M, Irkilata HC, Yildirim I, Tahmaz L, Dayanc M. Testosterone might cause relaxation of human corpus cavernosum by potassium channel opening action. Urology. 2009;74(1):229-232.

  119. Yildiz O, Seyrek M. Effects of testosterone on vascular tone. In Chichinadze K (ed.) Testosterone: Biochemistry, therapeutic uses and physiological effects. Nova Science Publishers; 2012. p159-183.

  120. Murakami E, Iwata H, Imaizumi M, Takemura H. Prevention of arterial graft spasm by botulinum toxin: an in-vitro experiment. Interact Cardiovasc Thorac Surg. 2009;9(3):395-398.

  121. Ozdemir C, Ikizler M, Besogul Y, Karakaya A, Sirmagul B. An alternative agent for radial arterial graft spasm: application of topical iloprost. Scand Cardiovasc J. 2007;41(3):201-206.

  122. Mussa S, Choudhary BP, Taggart DP. Radial artery conduits for coronary artery bypass grafting: current perspective. J Thorac Cardiovasc Surg. 2005;129(2):250-253. Review.

  123. [123] Barner HB. The continuing evolution of arterial conduits. Ann Thorac Surg. 1999;68(3 Suppl):S1-8.

  124. Shah PJ, Bui K, Blackmore S, Gordon I, Hare DL, Fuller J, Seevanayagam S, Buxton BF. Has the in situ right internal thoracic artery been overlooked? An angiographic study of the radial artery, internal thoracic arteries and saphenous vein graft patencies in symptomatic patients. Eur J Cardiothorac Surg. 2005;27(5):870-875.

  125. Sahin MA, Guler A, Cingoz F, Yokusoglu M, Demirkol S, Ozal E, Demirkilic U, Arslan M. Mid-term results of radial artery grafts used in coronary bypass surgery. Gulhane Med J. 2012; 54(1): 7-13. Turkish.

  126. Possati G, Gaudino M, Prati F, Alessandrini F, Trani C, Glieca F, Mazzari MA, Luciani N, Schiavoni G. Long-term results of the radial artery used for myocardial revascularization. Circulation. 2003;108(11):1350-1354.

  127. Lockowandt U, Ritchie A, Grossebener M, Franco-Cereceda A. Endothelin and effects of endothelin-receptor activation in the mammary and radial artery. Scand Cardiovasc J. 2004;38(4):240-244.

  128. Gupte SA, Zias EA, Sarabu MR, Wolin MS. Role of prostaglandins in mediating differences in human internal mammary and radial artery relaxation elicited by hypoxia. J Pharmacol Exp Ther. 2004;311(2):510-518.

  129. Attaran S, John L, El-Gamel A. Clinical and potential use of pharmacological agents to reduce radial artery spasm in coronary artery surgery. Ann Thorac Surg. 2008;85(4):1483-1489. Review.

  130. Vuurmans T, Hilton D. Brewing the right cocktail for radial intervention. Indian Heart J. 2010;62(3):221-225. Review.

  131. Suma H. Optimal use of the gastroepiploic artery. Semin Thorac Cardiovasc Surg. 1996;8(1):24-28.

  132. Koike R, Suma H, Kondo K, Oku T, Satoh H, Fukuda S, Takeuchi A. Pharmacological response of internal mammary artery and gastroepiploic artery. Ann Thorac Surg. 1990;50(3):384-386.

  133. Ochiai M, Ohno M, Taguchi J, Hara K, Suma H, Isshiki T, Yamaguchi T, Kurokawa K. Responses of human gastroepiploic arteries to vasoactive substances: comparison with responses of internal mammary arteries and saphenous veins. J Thorac Cardiovasc Surg. 1992;104(2):453-438.

  134. He GW, Yang CQ. Comparison among arterial grafts and coronary artery. An attempt at functional classification. J Thorac Cardiovasc Surg. 1995;109(4):707-715.

  135. Yang Z, Siebenmann R, Studer M, Egloff L, Lüscher TF. Similar endothelium-dependent relaxation, but enhanced contractility, of the right gastroepiploic artery as compared with the internal mammary artery. J Thorac Cardiovasc Surg. 1992;104(2):459-464.

  136. Ali AT, Montgomery WD, Santamore WP, Spence PA. Preventing gastroepiploic artery spasm: papaverine vs calcium channel blockade. J Surg Res. 199715;71(1):41-48.

  137. Formica F, Ferro O, Brustia M, Corti F, Colagrande L, Bosisio E, Paolini G. Effects of papaverine and glycerylnitrate-verapamil solution as topical and intraluminal vasodilators for internal thoracic artery. Ann Thorac Surg. 2006;81(1):120-124.

  138. Mügge A, Barton MR, Cremer J, Frombach R, Lichtlen PR. Different vascular reactivity of human internal mammary and inferior epigastric arteries in vitro. Ann Thorac Surg. 1993;56(5):1085-1089.

  139. Tadjkarimi S, O'Neil GS, Schyns CJ, Borland JA, Chester AH, Yacoub MH. Vasoconstrictor profile of the inferior epigastric artery. Ann Thorac Surg. 1993;56(5):1090-1095.

  140. Tadjkarimi S, Chester AH, Borland JA, Schyns CJ, O'Neil GS, Yacoub MH. Endothelial function and vasodilator profile of the inferior epigastric artery. Ann Thorac Surg. 1994;58(1):207-210.