Open access peer-reviewed Edited Volume

Receptors P1 and P2 as Targets for Drug Therapy in Humans

Edited by Robson Faria

Oswaldo Cruz Foundation

This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.

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Receptors P1 and P2 as Targets for Drug Therapy in HumansEdited by Robson Faria

Published: March 11th 2020

DOI: 10.5772/intechopen.78115

ISBN: 978-1-78984-535-8

Print ISBN: 978-1-78984-534-1

eBook (PDF) ISBN: 978-1-83880-078-9

Copyright year: 2020

Books open for chapter submissions

1634 Total Chapter Downloads


Open access peer-reviewed

1. Introductory Chapter: Receptors P1 and P2 as Targets for Drug Therapy in Humans

By Robson Faria


Open access peer-reviewed

2. Functions of Purinergic Receptors

By Eren Sarikaya


Open access peer-reviewed

3. Purinergic Signaling and Dental Orofacial Pain

By Xiuxin Liu


Open access peer-reviewed

4. The Role of Purinergic Signaling in the Pathophysiology of Perinatal Hypoxic-Ischemic Encephalopathy

By Tagore M. Morais-Lima, Joana C. Vicentini, Anael V.P. Alberto, Pedro H.M. de Freitas, Caio M. Perret, Natiele C. da Silva Ferreira, Deepaneeta Sarmah, Bharati Sinha, Gopika Das, Pallab Bhattacharya, Xin Wang, Luiz A. Alves and Renato Rozental


Open access peer-reviewed

5. A Brief View of Molecular Modeling Approaches to P2 Receptors

By Anael V.P. Alberto, Lucianna H.S. Santos, Rafael Ferreira, Dinarte N.M. Ferreira and Luiz A. Alves


Edited Volume and chapters are indexed in

  • Worldcat
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  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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