Open access peer-reviewed Edited Volume


Human Diseases and Protein Functions


Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field. This book covers four important and diverse areas of current proteomic research: Proteomic Discovery of Disease Biomarkers, Proteomic Analysis of Protein Functions, Proteomic Approaches to Dissecting Disease Processes, and Organelles and Secretome Proteomics. We believe that clinicians, students and laboratory researchers who are interested in Proteomics and its applications in the biomedical field will find this book useful and enlightening. The use of proteomic methods in studying proteins in various human diseases has become an essential part of biomedical research.

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ProteomicsHuman Diseases and Protein FunctionsEdited by Tsz Kwong Man

Published: February 10th 2012

DOI: 10.5772/1288

ISBN: 978-953-307-832-8

eBook (PDF) ISBN: 978-953-51-5183-8

Copyright year: 2012

Books open for chapter submissions

48520 Total Chapter Downloads

13 Crossref Citations

36 Web of Science Citations

49 Dimensions Citations


Open access peer-reviewed

1. Overview of Current Proteomic Approaches for Discovery of Vascular Biomarkers of Atherosclerosis

By Lepedda Antonio Junior, Zinellu Elisabetta and Formato Marilena


Open access peer-reviewed

2. From Biomarker Discovery to Clinical Evaluation for Early Diagnosis of Lung Surgery-Induced Injury

By Mei-Ling Tsai, Shu-Hui Chen, Chih-Ching Chang and Ming-Ho Wu


Open access peer-reviewed

3. Urinary Exosomes for Protein Biomarker Research

By Delfin Albert Amal Raj, Immacolata Fiume, Giovambattista Capasso and Gabriella Pocsfalvi


Open access peer-reviewed

4. Circadian Proteomics and Its Unique Advantage for Discovery of Biomarkers of Heart Disease

By Peter S. Podobed, Gordon M. Kirby and Tami A. Martino


Open access peer-reviewed

5. Exploring the Role of Biomarkers for the Diagnosis and Management of Traumatic Brain Injury Patients

By Linda Papa


Open access peer-reviewed

6. Comparative Proteomics: An Approach to Elucidating the Function of a Novel Gene Called BRE

By Kenneth Ka Ho Lee, Mei KuenTang, John Yeuk-Hon Chan, Yiu Loon Chui, Elve Chen, Yao Yao, Olivia Miu Yung Ngan and Henry Siu Sum Lee


Open access peer-reviewed

7. Proteomic Approaches to Unraveling the RB/E2F Regulatory Pathway

By Jone Mitxelena, Nerea Osinalde, Jesus M. Arizmendi, Asier Fullaondo and Ana M. Zubiaga


Open access peer-reviewed

8. F0F1 ATP Synthase: A Fascinating Challenge for Proteomics

By Federica Dabbeni-Sala, Amit Kumar Rai and Giovanna Lippe


Open access peer-reviewed

9. Proteomic Analysis of Wnt-Dependent Dishevelled-Based Supermolecular Complexes

By Noriko Yokoyama


Open access peer-reviewed

10. Identification of the Novel Plasminogen Receptor, Plg-RKT

By Lindsey A. Miles, Nicholas M. Andronicos, Emily I. Chen, Nagyung Baik, Hongdong Bai, Caitlin M. Parmer, Shahrzad Lighvani, Samir Nangia, William B. Kiosses, Mark P. Kamps, John R. Yates III and Robert J. Parmer


Open access peer-reviewed

11. Posttranslational Modifications of Myosin Light Chains Determine the Protein Fate

By Virgilio J. J. Cadete and Grzegorz Sawicki


Open access peer-reviewed

12. Proteomic Study of Esophageal Squamous Cell Carcinoma

By Yi-Jun Qi and Jen-Fu Chiu


Open access peer-reviewed

13. Multidimensional Proteomics for the Identification of Endothelial Post Mortem Signals of Importance in Vascular Remodeling

By Isabelle Sirois, Alexey V. Pshezhetsky and Marie-Josée Hébert


Open access peer-reviewed

14. The Microtubule-Dissociating Tau in Neurological Disorders

By Francisco José Fernández-Gómez, Susanna Schraen-Maschke and Luc Buée


Open access peer-reviewed

15. Identification of Factors Involved in Neurogenesis Recovery After Irradiation of the Adult Mouse Subventricular Zone: A Preliminary Study

By François Chevalier, Alexandra Chicheportiche, Mathieu Daynac, Jordane Depagne, Pascale Bertrand, François D. Boussin and Marc-André Mouthon


Open access peer-reviewed

16. Analysis of Organelle Dynamics by Quantitative Mass Spectrometry Based Proteomics

By Florian Fröhlich, Tobias C. Walther and Romain Christiano


Open access peer-reviewed

17. Mitochondrial Proteomics: From Structure to Function

By Bernardo A. Petriz, Jeeser A. Almeida, Mirna S. Freire, Luiz A. O. Rocha, Taia M. B. Rezende and Octavio L. Franco


Open access peer-reviewed

18. Proteomic Analysis of Plasma Membrane Proteins in an In Vitro Blood-Brain Barrier Model

By Sophie Duban-Deweer, Johan Hachani, Barbara Deracinois, Roméo Cecchelli, Christophe Flahaut and Yannis Karamanos


Open access peer-reviewed

19. Quantitative Proteomics for Investigation of Secreted Factors: Focus on Muscle Secretome

By Jeanette Henningsen, Blagoy Blagoev and Irina Kratchmarova


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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