Open access peer-reviewed Edited Volume

Protein Kinases

Edited by Gabriela Da Silva Xavier

Imperial College London, United Kingdom

Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development.

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Protein KinasesEdited by Gabriela Da Silva Xavier

Published: June 5th 2012

DOI: 10.5772/2334

ISBN: 978-953-51-0640-1

eBook (PDF) ISBN: 978-953-51-5302-3

Copyright year: 2012

Books open for chapter submissions

39846 Total Chapter Downloads

18 Crossref Citations

25 Web of Science Citations

32 Dimensions Citations


Open access peer-reviewed

1. The Target of Rapamycin: Structure and Functions

By Chang-Chih Wu, Po-Chien Chou and Estela Jacinto


Open access peer-reviewed

2. SNF1/AMP-Activated Protein Kinases: Genes, Expression and Biological Role

By Dmytro O. Minchenko and Oleksandr H. Minchenko


Open access peer-reviewed

3. Alternating Phosphorylation with O-GlcNAc Modification: Another Way to Control Protein Function

By Victor V. Lima and Rita C. Tostes


Open access peer-reviewed

4. Technologies for the Use of Protein Kinases into Medical Applications

By Yoshiki Katayama


Open access peer-reviewed

5. Role of Kinases and Phosphatases in Host-Pathogen Interactions

By Horacio Bach


Open access peer-reviewed

6. Pathogen Strategies to Evade Innate Immune Response: A Signaling Point of View

By Bruno Miguel Neves, Maria Celeste Lopes and Maria Teresa Cruz


Open access peer-reviewed

7. Phosphorylation-Regulated Cell Surface Expression of Membrane Proteins

By Yukari Okamoto and Sojin Shikano


Open access peer-reviewed

8. Regulation of Retrotransposition of Long Interspersed Element-1 by Mitogen-Activated Protein Kinases

By Yukihito Ishizaka, Noriyuki Okudaira and Tadashi Okamura


Open access peer-reviewed

9. Connexins as Substrates for Protein Kinases and Phosphoprotein Phosphatases

By José L. Vega, Elizabeth Baeza, Viviana M. Berthoud and Juan C. Sáez


Open access peer-reviewed

10. Protein Phosphatases Drive Mitotic Exit

By Megan Chircop


Open access peer-reviewed

11. Regulations and Functions of ICK/MAK/MOK - A Novel MAPK-Related Kinase Family Linked to Human Diseases

By Zheng "John" Fu


Open access peer-reviewed

12. Protein Kinases and Protein Phosphatases as Participants in Signal Transduction of Erythrocytes

By Ana Maneva and Lilia Maneva-Radicheva


Open access peer-reviewed

13. Role of Protein Kinase Network in Excitation-Contraction Coupling in Smooth Muscle Cell

By Etienne Roux, Prisca Mbikou and Ales Fajmut


Open access peer-reviewed

14. Regulation of Na+/H+ Exchanger Isoform 3 by Protein Kinase A in the Renal Proximal Tubule

By Adriana Castello Costa Girardi and Luciene Regina Carraro-Lacroix


Open access peer-reviewed

15. cGMP-Dependent Protein Kinase in the Regulation of Cardiovascular Functions

By Yuansheng Gao, Dou Dou, Xue Qin, Hui Qi and Lei Ying


Open access peer-reviewed

16. The Crucial Role of c-Src Tyrosine Kinase in Bone Metabolism

By Barbara Peruzzi, Nadia Rucci and Anna Teti


Open access peer-reviewed

17. The ERK MAPK Pathway in Bone and Cartilage Formation

By Takehiko Matsushita and Shunichi Murakami


Open access peer-reviewed

18. Protein Kinases and Pancreatic Islet Function

By Gabriela Da Silva Xavier


Open access peer-reviewed

19. Raf Serine/Threonine Protein Kinases: Immunohistochemical Localization in the Mammalian Nervous System

By András Mihály


Open access peer-reviewed

20. Protein Kinases in Spinal Plasticity: A Role for Metabotropic Glutamate Receptors

By J. Russell Huie and Adam R. Ferguson


Open access peer-reviewed

21. Protein Kinases and Pain

By Mani Indiana Funez, Fabiane Hiratsuka Veiga de Souza, José Eduardo Pandossio and Paulo Gustavo Barboni Dantas Nascimento


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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