Open access peer-reviewed Edited volume

Prion

An Overview

Edited by Yusuf Tutar

Sivas Cumhuriyet University

Protein aggregation causes malfunction in several biochemical processes. Genetic and spontaneous formations of these transmissible spongiform encephalopathies are fatal to humans and animals. Conformational change of normal form of the protein to misfolded form causes its accumulation. The misfolded infectious protein agent forms the pathogenesis of the disease. This book presents pathology of the disease along with current knowledge of the structure-activity mechanism in the first two sections. Dyshomeostasis of metals is implicated in the pathogenesis of prions, and this influence is discussed further to understand the prion mechanism. Genetic resistance and immunobiology of the disease are elaborated in the following section. Finally, a computational study on the dynamics of the prion propagation provides a structural basis of the mechanism.

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IntechOpen
PrionAn OverviewEdited by Yusuf Tutar

Published: March 8th 2017

DOI: 10.5772/63289

ISBN: 978-953-51-3002-4

Print ISBN: 978-953-51-3001-7

Books open for chapter submissions

4740 Total Chapter Downloads

1 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Classical and Atypical Bovine Spongiform Encephalopathy: Epidemiology, Pathogenesis and Diagnosis

By Barbara Iulini, Elena Vallino Costassa, Cristiano Corona, Daniela Meloni, Alessandra Favole, Maria Mazza, Maria Caramelli, Cristiana Maurella and Cristina Casalone

593

Open access peer-reviewed

2. Past, Present and Potential Future Prion Disease Treatment Strategies

By Pamela J. Skinner and Davis M. Seelig

602

Open access peer-reviewed

3. Structure-Property Relationship of Amyloidogenic Prion Nanofibrils

By Myeongsang Lee, Hyunsung Choi, Jae In Kim, Gwonchan Yoon and Sungsoo Na

270

Open access peer-reviewed

4. The Role of the Hsp40 Chaperone Sis1 in Yeast Prion Propagation

By Michael Reidy

490

Open access peer-reviewed

5. Molecular Signature in Human and Animal Prion Disorders

By Michele Fiorini, Matilde Bongianni and Gianluigi Zanusso

403

Open access peer-reviewed

6. Disruption of Metal Homeostasis and the Pathogenesis of Prion Diseases

By Masahiro Kawahara, Ken‐ichiro Tanaka and Dai Mizuno

498

Open access peer-reviewed

7. Immunobiology of Prion Diseases

By Konstantinos Xanthopoulos, Dimitra Dafou, Eirini Kanata and Theodoros Sklaviadis

488

Open access peer-reviewed

8. Genetic Resistance to Prion Diseases

By Yalçın Yaman and Cemal Ün

517

Open access peer-reviewed

9. Neurobehavioral Testing in Prion Disease Studies

By Davis M. Seelig, Michael A. Benneyworth and Damani N. Bryant

411

Open access peer-reviewed

10. Mathematical Modeling of Prion Disease

By Suzanne S. Sindi

468

Edited volume and chapters are indexed in

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