\r\n\tPPIs may be studied from different perspectives including Biochemistry, Chemistry, Molecular Dynamics, Signal Transduction, Transport across membranes, cellular metabolism, etc. This book will deal with the modern concepts in the field of PPI including but not limited to: Characterization of proteins, Structural analysis of proteins, Functional analysis of proteins, Signaling pathway analysis, Domain analysis, Evolutionary analysis of proteins, Protein – Protein Interaction Networks, Protein – Protein Interaction and OMICS, Protein – Protein Interaction approaches
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However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. 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