Open access peer-reviewed Edited Volume

Peripheral Nerve Regeneration

From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Development

Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.

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Peripheral Nerve RegenerationFrom Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies DevelopmentEdited by Ana Colette Maurício

Published: May 31st 2017

DOI: 10.5772/65612

ISBN: 978-953-51-3166-3

Print ISBN: 978-953-51-3165-6

eBook (PDF) ISBN: 978-953-51-4812-8

Copyright year: 2017

Books open for chapter submissions

11420 Total Chapter Downloads

4 Crossref Citations

5 Web of Science Citations

10 Dimensions Citations


Open access peer-reviewed

1. Peripheral Nerve Injury and Current Treatment Strategies

By Aysu Hayriye Tezcan


Open access peer-reviewed

2. Peripheral Nerve Entrapment and their Surgical Treatment

By Vicente Vanaclocha‐Vanaclocha, Nieves Sáiz‐Sapena, Jose María Ortiz‐Criado and Nieves Vanaclocha


Open access peer-reviewed

3. Nerve Transfers in the Treatment of Peripheral Nerve Injuries

By Vicente Vanaclocha-Vanaclocha, Jose María Ortiz-Criado, Nieves Sáiz-Sapena and Nieves Vanaclocha


Open access peer-reviewed

4. Surgical Treatment of Brachial Plexus Injury

By Pavel Haninec and Libor Mencl


Open access peer-reviewed

5. The Role of Nucleotides in Glial Cells during Peripheral Nerve Trauma and Compressive Disorders

By Marina Manhães, Marcelo Cesar, Rayssa Justo, Mauro Geller, Mendel Suchmacher and Rafael Cisne


Open access peer-reviewed

6. The Role of Pharmacological Agents in Nerve Regeneration after Peripheral Nerve Repair

By Agon Mekaj and Ymer Mekaj


Open access peer-reviewed

7. Adult and Reparative Neurogenesis in Fish Brain

By Evgeniya V. Pushchina, Anatoly A. Varaksin, Mariya E. Stukaneva and Eva I. Zharikova


Open access peer-reviewed

8. Effect of Local Delivery of GDNF Conjugated Iron Oxide Nanoparticles on Nerve Regeneration along Long Chitosan Nerve Guide

By Federica Fregnan, Michela Morano, Ofra Ziv-Polat, Mira M. Mandelbaum-Livnat, Moshe Nissan, Tolmasov Michael, Akiva Koren, Tali Biran, Yifat Bitan, Evgeniy Reider, Mara Almog, Nicoletta Viano, Shimon Rochkind, Stefano Geuna and Abraham Shahar


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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