Open access peer-reviewed Edited Volume

Pancreatic Cancer

Molecular Mechanism and Targets

This book provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer. Book also summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail. Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5-flourouracil.

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Pancreatic CancerMolecular Mechanism and TargetsEdited by Sanjay Srivastava

Published: March 23rd 2012

DOI: 10.5772/1271

ISBN: 978-953-51-0410-0

eBook (PDF) ISBN: 978-953-51-6935-2

Copyright year: 2012

Books open for chapter submissions

55942 Total Chapter Downloads

7 Crossref Citations

10 Web of Science Citations

17 Dimensions Citations


Open access peer-reviewed

1. Risk Factors in Pancreatic Cancer

By Andrada Seicean and Radu Seicean


Open access peer-reviewed

2. Epigenetics and Pancreatic Cancer: The Role of Nutrigenomics

By Beverly D. Lyn-Cook


Open access peer-reviewed

3. Characterization of the Molecular Genetic Mechanisms that Contribute to Pancreatic Cancer Carcinogenesis

By Jiaming Qian, Hong Yang, Jingnan Li and Jian Wang


Open access peer-reviewed

4. Pancreatic Cancer: Current Concepts in Invasion and Metastasis

By Sara Chiblak and Amir Abdollahi


Open access peer-reviewed

5. Nitric Oxide Regulates Growth Factor Signaling in Pancreatic Cancer Cells

By Hiroki Sugita, Satoshi Furuhashi and Hideo Baba


Open access peer-reviewed

6. Kinase Activity is Required for Growth Regulation but not Invasion Suppression by Syk Kinase in Pancreatic Adenocarcinoma Cells

By Tracy Layton, Felizza Gunderson, Chia-Yao Lee, Cristel Stalens and Steve Silletti


Open access peer-reviewed

7. New Targets for Therapy in Pancreatic Cancer

By Nicola Tinari, Michele De Tursi, Antonino Grassadonia, Marinella Zilli, Stefano Iacobelli and Clara Natoli


Open access peer-reviewed

8. Failure of Pancreatic Cancer Chemotherapy: Consequences of Drug Resistance Mechanisms

By Vikas Bhardwaj, Satya Murthy Tadinada, James C.K. Lai and Alok Bhushan


Open access peer-reviewed

9. Prevention of Pancreatic Cancer

By Xia Jiang, Shigeru Sugaya, Qian Ren, Tetsuo Sato, Takeshi Tanaka, Fujii Katsunori, Kazuko Kita and Nobuo Suzuki


Open access peer-reviewed

10. Vitamin D for the Prevention and Treatment of Pancreatic Cancer

By Kun-Chun Chiang and Tai C. Chen


Open access peer-reviewed

11. Molecular Targets of Benzyl Isothiocyanates in Pancreatic Cancer

By Srinivas Reddy Boreddy, Kartick C. Pramanik and Sanjay K. Srivastava


Open access peer-reviewed

12. The Potential Role of Curcumin for Treatment of Pancreatic Cancer

By Masashi Kanai, Sushovan Guha and Bharat B. Aggarwal


Open access peer-reviewed

13. Immunotherapy for Pancreatic Cancer

By Shigeo Koido, Sadamu Homma, Akitaka Takahara, Yoshihisa Namiki, Hideo Komita, Kan Uchiyama, Toshifumi Ohkusa and Hisao Tajiri


Open access peer-reviewed

14. The Role of Mesothelin in Pancreatic Cancer

By Christian Marin-Muller, Changyi Chen and Qizhi Yao


Open access peer-reviewed

15. Establishment of Primary Cell Lines in Pancreatic Cancer

By Felix Rückert, Christian Pilarsky and Robert Grützmann


Open access peer-reviewed

16. Disruption of Cell Cycle Machinery in Pancreatic Cancer

By Steven Kennedy, Hannah Berrett and Robert J. Sheaff


Open access peer-reviewed

17. Glycans and Galectins: Sweet New Approaches in Pancreatic Cancer Diagnosis and Treatment

By Neus Martínez-Bosch and Pilar Navarro


Open access peer-reviewed

18. The Adhesion Molecule L1CAM as a Novel Therapeutic Target for Treatment of Pancreatic Cancer Patients?

By Susanne Sebens and Heiner Schäfer


Open access peer-reviewed

19. p53 Re-Activating Small Molecule Inhibitors for the Treatment of Pancreatic Cancer

By Asfar S. Azmi, Minsig Choi and Ramzi M. Mohammad


Open access peer-reviewed

20. Toll-Like Receptors as Novel Therapeutic Targets for the Treatment of Pancreatic Cancer

By Kelly D. McCall, Fabian Benencia, Leonard D. Kohn, Ramiro Malgor, Anthony Schwartz and Frank L. Schwartz


Open access peer-reviewed

21. Grb7 - A Newly Emerging Target in Pancreatic Cancer

By Nigus D. Ambaye and Jacqueline A. Wilce


Open access peer-reviewed

22. Human Telomerase Reverse Transcriptase Gene Antisense Oligonucleotide Increases the Sensitivity of Pancreatic Cancer Cells to Gemcitabine In Vitro

By Yong-ping Liu, Yang Ling, Yue-di Hu, Ying-ze Kong, Feng Wang and Peng Li


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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