Open access peer-reviewed Edited volume

Osteosarcoma

Biology, Behavior and Mechanisms

Co-editor:

Osteosarcoma is the most common malignant bone tumor and mainly affects children, adolescents, and young adults. Osteosarcoma shows significant genetic instability, resulting in very complex biology with multifaceted cellular and molecular mechanisms and behavior. Although clinical outcomes, both prognostic and functional, of osteosarcoma dramatically improved in the 1980s, the prognoses of the patients with relapsed and/or metastatic disease remained very poor in spite of our continuous efforts to overcome this difficulty. This book aims to delve into the current advances of basic and clinical sciences in osteosarcoma that are guiding the future directions of its research and clinical practice. The knowledge presented here will lead to further inspiration, ideas, and novel insights into the field of osteosarcoma research. Hopefully, this work will foster improvement of the prognosis for patients suffering from the disease.

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OsteosarcomaBiology, Behavior and MechanismsEdited by Kanya Honoki

Published: April 26th 2017

DOI: 10.5772/62700

ISBN: 978-953-51-3096-3

Print ISBN: 978-953-51-3095-6

Books open for chapter submissions

5590 Total Chapter Downloads

1 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: From Chaos to Cosmos – Toward Precision Medicine in Osteosarcoma

By Kanya Honoki and Kurt Richard Weiss

277

Open access peer-reviewed

2. Characterizing Osteosarcoma Through PTEN and PI3K: What p53 and Rb1 Can’t Tell Us

By Matthew G. Cable and R. Lor Randall

301

Open access peer-reviewed

3. The Use of Molecular Pathway Inhibitors in the Treatment of Osteosarcoma

By Adel Mahjoub, Jared A. Crasto, Jonathan Mandell, Mitchell S. Fourman, Rashmi Agarwal and Kurt R. Weiss

347

Open access peer-reviewed

4. Osteosarcoma: From Molecular Biology to Mesenchymal Stem Cells

By Matthew L. Broadhead, Saumiyar Sivaji, Zsolt Balogh and Peter F.M. Choong

375

Open access peer-reviewed

5. Microenvironment Signals and Mechanisms in the Regulation of Osteosarcoma

By Yu Zhang, Qing Mai, Xiaowen Zhang, Chunyuan Xie and Yan Zhang

451

Open access peer-reviewed

6. Immune Environment and Osteosarcoma

By Marie-Françoise Heymann and Dominique Heymann

398

Open access peer-reviewed

7. Immune Checkpoint Blockade: Subjugation of the Masses

By Danielle M. Lussier, Nicole T. Appel, John L. Johnson and Joseph N. Blattman

337

Open access peer-reviewed

8. Osteosarcomagenesis: Biology, Development, Metastasis, and Mechanisms of Pain

By Branden A. Smeester, Branden S. Moriarity and Alvin J. Beitz

351

Open access peer-reviewed

9. The Biological Role and Clinical Implication of MicroRNAs in Osteosarcoma

By Yutaka Nezu, Kosuke Matsuo, Akira Kawai, Tomoyuki Saito and Takahiro Ochiya

345

Open access peer-reviewed

10. OMICS Approach for Identifying Predictive Biomarkers in Osteosarcoma

By Tadashi Kondo

319

Open access peer-reviewed

11. Biological Reconstruction Using Liquid Nitrogen-Treated Tumor Bearing Bone

By Norio Yamamoto and Hiroyuki Tsuchiya

351

Open access peer-reviewed

12. Osteosarcoma of the Jaw: Classification, Diagnosis and Treatment

By Daris Ferrari, Laura Moneghini, Fabiana Allevi, Gaetano Bulfamante and Federico Biglioli

686

Open access peer-reviewed

13. A Dog in the Cancer Fight: Comparative Oncology in Osteosarcoma

By Alexander L. Lazarides, Allison B. Putterman, William C. Eward and Cindy Eward

1052

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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