Open access peer-reviewed Edited Volume


Biology, Behavior and Mechanisms

Edited by Kanya Honoki

Nara Medical University, Japan


Kurt Weiss

University of Pittsburgh, United States of America

Osteosarcoma is the most common malignant bone tumor and mainly affects children, adolescents, and young adults. Osteosarcoma shows significant genetic instability, resulting in very complex biology with multifaceted cellular and molecular mechanisms and behavior. Although clinical outcomes, both prognostic and functional, of osteosarcoma dramatically improved in the 1980s, the prognoses of the patients with relapsed and/or metastatic disease remained very poor in spite of our continuous efforts to overcome this difficulty. This book aims to delve into the current advances of basic and clinical sciences in osteosarcoma that are guiding the future directions of its research and clinical practice. The knowledge presented here will lead to further inspiration, ideas, and novel insights into the field of osteosarcoma research. Hopefully, this work will foster improvement of the prognosis for patients suffering from the disease.

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OsteosarcomaBiology, Behavior and MechanismsEdited by Kanya Honoki

Published: April 26th 2017

DOI: 10.5772/62700

ISBN: 978-953-51-3096-3

Print ISBN: 978-953-51-3095-6

eBook (PDF) ISBN: 978-953-51-4859-3

Copyright year: 2017

Books open for chapter submissions

16090 Total Chapter Downloads

6 Crossref Citations

3 Web of Science Citations

11 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: From Chaos to Cosmos – Toward Precision Medicine in Osteosarcoma

By Kanya Honoki and Kurt Richard Weiss


Open access peer-reviewed

2. Characterizing Osteosarcoma Through PTEN and PI3K: What p53 and Rb1 Can’t Tell Us

By Matthew G. Cable and R. Lor Randall


Open access peer-reviewed

3. The Use of Molecular Pathway Inhibitors in the Treatment of Osteosarcoma

By Adel Mahjoub, Jared A. Crasto, Jonathan Mandell, Mitchell S. Fourman, Rashmi Agarwal and Kurt R. Weiss


Open access peer-reviewed

4. Osteosarcoma: From Molecular Biology to Mesenchymal Stem Cells

By Matthew L. Broadhead, Saumiyar Sivaji, Zsolt Balogh and Peter F.M. Choong


Open access peer-reviewed

5. Microenvironment Signals and Mechanisms in the Regulation of Osteosarcoma

By Yu Zhang, Qing Mai, Xiaowen Zhang, Chunyuan Xie and Yan Zhang


Open access peer-reviewed

6. Immune Environment and Osteosarcoma

By Marie-Françoise Heymann and Dominique Heymann


Open access peer-reviewed

7. Immune Checkpoint Blockade: Subjugation of the Masses

By Danielle M. Lussier, Nicole T. Appel, John L. Johnson and Joseph N. Blattman


Open access peer-reviewed

8. Osteosarcomagenesis: Biology, Development, Metastasis, and Mechanisms of Pain

By Branden A. Smeester, Branden S. Moriarity and Alvin J. Beitz


Open access peer-reviewed

9. The Biological Role and Clinical Implication of MicroRNAs in Osteosarcoma

By Yutaka Nezu, Kosuke Matsuo, Akira Kawai, Tomoyuki Saito and Takahiro Ochiya


Open access peer-reviewed

10. OMICS Approach for Identifying Predictive Biomarkers in Osteosarcoma

By Tadashi Kondo


Open access peer-reviewed

11. Biological Reconstruction Using Liquid Nitrogen-Treated Tumor Bearing Bone

By Norio Yamamoto and Hiroyuki Tsuchiya


Open access peer-reviewed

12. Osteosarcoma of the Jaw: Classification, Diagnosis and Treatment

By Daris Ferrari, Laura Moneghini, Fabiana Allevi, Gaetano Bulfamante and Federico Biglioli


Open access peer-reviewed

13. A Dog in the Cancer Fight: Comparative Oncology in Osteosarcoma

By Alexander L. Lazarides, Allison B. Putterman, William C. Eward and Cindy Eward


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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