Open access peer-reviewed Edited Volume

Oncogenes and Carcinogenesis

Edited by Pinar Erkekoglu

Hacettepe University

Oncogenes are mutated and/or overexpressed at high levels in tumor cells. Tumors of the lung, breast, pancreas, and colon may display specific oncogenetic features. These tumors have been largely associated with exposure to environmental carcinogens and a variety of biological agents, including viruses. These carcinogens can induce specific genetic and epigenetic alterations in these tissues, leading to aberrant functioning of oncogenes and tumor suppressor genes. On the microRNAs (miRNAs) there are significant modifiers of both transcription and translation of oncogenes in carcinogenesis. In the last 50 years, several oncogenes and microRNAs related to these oncogenes have been identified in different types of human cancers. It is now clear that high expression of oncogenes, DNA damage response, and regulation of the cell cycle are related to the circadian clock. This book will mainly focus on the expressions of different oncogenes in breast, colon, and lung cancers. Moreover, readers will gain qualified scientific knowledge of the alterations in miRNAs in different types of cancers and the effects of the circadian clock on the expression of oncogenes in carcinogenesis.

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Oncogenes and CarcinogenesisEdited by Pinar Erkekoglu

Published: March 6th 2019

DOI: 10.5772/intechopen.74727

ISBN: 978-1-78985-172-4

Print ISBN: 978-1-78985-171-7

Copyright year: 2019

Books open for chapter submissions

719 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: Interactions between Environmental Chemicals and KRAS Oncogene in Different Cancers - Special Focus on Colorectal, Pancreatic, and Lung Cancers

By Pinar Erkekoglu

147

Open access peer-reviewed

2. A Molecular Link between the Circadian Clock, DNA Damage Responses, and Oncogene Activation

By Yoshimi Okamoto-Uchida, Junko Izawa and Jun Hirayama

162

Open access peer-reviewed

3. MicroRNAs (miRNAs) in Colorectal Cancer

By Burcin Baran, Nazli-Mert Ozupek, Gizem Calibasi-Kocal and Yasemin Basbinar

228

Open access peer-reviewed

4. The AIB1/NCOA3/SRC-3 Oncogene

By Max H. Kushner, Anna T. Riegel and Ghada M. Sharif

77

Open access peer-reviewed

5. Oncogenetics of Lung Cancer Induced by Environmental Carcinogens

By Victor D. Martinez, Adam P. Sage, Erin A. Marshall, Miwa Suzuki, Aaron A. Goodarzi, Graham Dellaire and Wan L. Lam

105

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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