Open access peer-reviewed Edited Volume

Novel Aspects on Motor Neuron Disease

Edited by Humberto Foyaca Sibat

Walter Sisulu University


Lourdes de Fátima Ibañez-Valdés

Walter Susulu University

Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book contains selected peer-reviewed chapters written by international researchers. In this publication, the readers will find a compilation of state-of-the-art reviews about etiology, therapies, investigations, the molecular basis of disease progression and clinical manifestations, and the genetic familial ALS, as well as novel therapeutic modalities. We look forward with confidence and pride to the remarkable role that this book will play for a new vision and mission.

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Novel Aspects on Motor Neuron DiseaseEdited by Humberto Foyaca Sibat

Published: May 20th 2020

DOI: 10.5772/intechopen.73840

ISBN: 978-1-83880-774-0

Print ISBN: 978-1-83880-773-3

eBook (PDF) ISBN: 978-1-83880-800-6

Copyright year: 2020

Books open for chapter submissions

2481 Total Chapter Downloads

1 Crossref Citations

1 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Introduction to Novel Aspects on Motor Neuron Disease

By Humberto Foyaca Sibat and Lourdes de Fátima Ibañez Valdés


Open access peer-reviewed

2. Contribution of Aberrant Astrocytes to Motor Neuron Damage and Death in the SOD1G93A Rat Experimental Model of ALS

By Gabriel Otero Damianovich, Olga Cristina Parada, Pablo Díaz-Amarilla, Eugenia Eloísa Isasi, Carmen Isabel Bolatto Pereira and Silvia Olivera-Bravo


Open access peer-reviewed

3. Stem Cell Therapy in Motor Neuron Disease

By Alok Sharma, Hemangi Sane, Nandini Gokulchandran, Prerna Badhe, Amruta Paranjape, Radhika Pradhan, Rohit Das and Hema Biju


Open access peer-reviewed

4. Introduction to Novel Motor Neuron Disease

By Humberto Foyaca Sibat and Lourdes de Fátima Ibañez Valdés


Open access peer-reviewed

5. Novel Aspects on Motor Neuron Disease: The Recent Genetic Studies on ALS

By Junling Wang


Open access peer-reviewed

6. Structural and Functional Consequences of the SMA-Linked Missense Mutations of the Survival Motor Neuron Protein: A Brief Update

By Wei Li


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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