Abstract
Soybean is a most important crop providing edible oil and plant protein source for human beings, in addition to animal feed because of high protein and oil content. This review summarized the progresses in the QTL mapping, candidate gene cloning and functional analysis and also the regulation of soybean oil and seed storage protein accumulation. Furthermore, as soybean genome has been sequenced and released, prospects of multiple omics and advanced biotechnology should be combined and applied for further refine research and high-quality breeding.
Keywords
- soybean
- seed oil content
- seed storage protein
1. Introduction
Soybean (
1.1. Soybean protein and oil content QTL analysis
Soybean oil and protein content were quantitative trait and effected by multiple genes and environments factors [2, 3]; there were over 312 soybean oil QTLs and 231 soybean protein QTLs having been detected by different population and environments (SoyBase, http://www.soybase.org), with the main mapping methods including the analysis of variance (ANOVA; [4]), interval mapping (IM; [5, 6, 7]), composite interval mapping (CIM; [8, 9]), multiple interval mapping (MIM; [10]) and inclusive composite interval mapping (ICIM; [11]). Among the published soybean oil content QTLs, some of them showed ‘hot regions’ that have been identified four or more times at the same or similar intervals in different studies, which include Gm05: 35.2–40.8 Mb, Gm09: 40.3–46.8 Mb, Gm12: 34.1–40.6 Mb, Gm14: 33.8–49.2 Mb, Gm15: 0.8–13.9 Mb, Gm18: 51.6–59.8 Mb, Gm19: 32.9–48.0 Mb and Gm20: 23.5–34.6 Mb [12]. For soybean protein content, there were also some ‘hot regions’ included Gm04: 43.6–47.7 Mb, Gm05: 39.7–41.4 Mb, Gm07: 4.2–9.6 Mb, Gm08: 5.8–10.2 Mb, Gm14: 4.8–9.6 Mb, Gm15: 0.0–7.5 Mb, Gm18: 47.9–54.0 Mb, Gm19: 35.5–42.1 Mb and Gm20: 2.1–34.2 Mb [13, 14]. Meta-analysis is a statistical method that could combine results from different sources in a single study [15]; it can increase QTL precision and validity by using mathematical models to refine the integration of QTLs [16] and have been performed in maize [17] and soybean [18] at the beginning of application. Meta-analysis method has also been employed to analyze the soybean oil and protein content separately by Qi et al. [19, 20].
However, soybean oil and protein content always showed the opposite relationship [21, 22], with the observation and data collections from many classical genetic analysis, the high oil variety with lower protein content and high protein variety with lower oil content [23]. And also, many classical genetic and breeding books or data noted the opposite relationship for soybean oil and protein content [2, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34]. Although it was very hard to find the locus which could increase soybean oil and protein content at the same time [35], based on the big amounts of QTL mapping results, few regions showed the same direction of contribution to soybean oil and protein content in the same genetic population. Orf et al. [36] mapped the additive QTL affected the soybean oil content at 39.5–41.2 Mb of Gm05 with the population crossed by Minsoy and Noir1, the results implied Minsoy bring the positive alleles for increasing soybean oil and protein content, however, Specht et al. [37] identified the similar region with the opposite results that Noir1 bring the positive alleles. Hyten et al. [38] identified a QTL at 4.8–8.7 Mb of Gm07 and the parent Williams bring the positive alleles for both traits. Reinprecht et al. [39] also demonstrated that the variety OX948 bring the positive alleles. Mao et al. [40] identified the additive QTLs affected the soybean oil and content at 51.2–56.3 Mb of Gm01, 1.0–2.3 Mb of Gm09 and 39.4–46.1 Mb of Gm19 in the cross population of Hefeng47 and Heinong37, which indicated that the soybean variety Heinong37 bring the positive alleles of those regions that could increase the soybean oil and protein content at the same time. Heinong37 was the only one Chinese variety, which may bring the positive alleles for both traits based on published data.
1.2. Soybean fatty acid composition biosynthesis and transcriptional regulation
The accumulation of starch, lipid and protein supplied the raw materials and energy for soybean seed growth and maturity. Lipid was one of the three significant raw materials, although the biochemical pathway about synthesis of lipid has been studied thoroughly, the regulation mechanism is unclear till now [41, 42, 43, 44, 45, 46, 47]. De novo synthesis of fatty acid mainly started in plant plastid. Acetyl -CoA is a precursor of soybean seed fatty acid synthesis. It is an important intermediate of many cellular metabolisms, and it synthesizes a lot in plant cell and then acetyl-CoA carboxylase (ACCase) catalyzes the first committed step of fatty acid synthesis, acetyl-CoA carboxylate to malonyl-CoA [48]. After that, malonyl-CoA has been catalyzed by fatty acid synthase complex (FAS) and proceeding of continuous polymerization reaction based on the acyl carbon chains synthesized with a frequency of two carbons per cycle. The growing acyl carbon chain binds to acyl-carried proteins (ACP) and termination with the acyl-ACP thioesterase or acyltransferase form into acyl ACP. Furthermore, different lengths of acyl ACP synthesized the acyl-CoA with acyl-CoA synthetase and transferred from the plasmids to the endoplasmic reticulum or the cytoplasm. At last, fatty acids were attached to glycerol to synthesize triacylglycerides (TAGs) with three different acyltransferases respectively [49, 50, 51, 52]. Till now, seed oil content can be increased by changing the expression levels of individual enzymes involved in oil metabolism [53, 54, 55, 56, 57, 58, 59]. However, the key enzyme responsible for TAG assembly is encoded by diacylglycerol acyltransferase 1 (
Fatty acid composition were determined mainly by five fatty acids, palmitic (C16:0), stearic (C18:0), oleic (C18:1), linoleic (C18:2) and linolenic (C18:3) [67, 68]. Most palmitic acid (16:0) produced by the type II synthase is elongated to stearic acid (18:0) [67, 69]. In recent decades, there were many reports about the QTLs of each components of fatty acid, and there were also some ‘hot regions’ for soybean seed linoleic included Gm05 39.36–40.87 Mb and Gm18 48.35–50.78 Mb (with the original QTLs from Diers and Shoemaker [70]; Bachlava et al. [71]; Li et al. [65]; Xie et al. [72]); for soybean seed linolenic included Gm02 17.07–34.9 Mb, Gm09 34.56–37.74 Mb, Gm14 17.08–39.5 Mb and 45.68–46.78 Mb, Gm15 6.7–7.71 Mb, 13.07–25.6 Mb and Gm19 35.75–37.38 Mb (with the original QTLs from Li et al. [65], Bachlava et al. [71]; Diers and Shoemaker [70]; Spencer et al. [73]; Reinprecht et al. [39]; Xie et al. [72]; Shibata et al. [74]; Hyten et al. [38]); for soybean seed oleic included Gm05 39.07–40.80 Mb and Gm18 49.24–51.95 Mb (with the original QTLs from Diers and Shoemaker [70]; Reinprecht et al. [39]; Xie et al. [72]); for soybean seed palmitic included Gm05 2.84–3.92 Mb, Gm09 7.74–11.83 Mb and 34.59–38.73 Mb, Gm15 9.13–13.16 Mb, Gm17 7.60–9.45 Mb and Gm18 38.38–41.09 Mb (with the original QTLs from Li et al. [75]; Wang et al. [76]; Xie et al. [72]; Hyten et al. [38]; Li et al. [65]; Kim et al. [77], Reinprecht et al. [39]). In soybean, stearoyl-acyl carrier protein desaturase (SAD) catalyzes the first step in seed oil biosynthesis, converting stearoyl-ACP to oleoyl-ACP, which plays a key role in determining the ratio of total saturated to unsaturated fatty acid in plants [35, 78, 79].Then, microsomal oleate desaturase (FAD2) and linoleoyl desaturase (FAD3) catalyze oleic to linoleic acid mainly in the sn-2 position, and then, fatty acid elongase converts fatty acids into a long-chain fatty acid [80]. The
However, overexpression of a single gene of fatty acid synthesis does not significantly improve the fatty acid biosynthesis [88, 89]. Fatty acid synthesis is regulated by some major classical transcription factors coupling with seed development, including
In addition, other transcription factors have been identified to affect oil content in Arabidopsis, including
1.3. Soybean seed storage protein (SSP) and transcriptional regulation
Soybean seed storage proteins (SSP) have been identified and classified into four basic categories, including albumins (water-soluble), globulins (salt-soluble), prolamins (alcohol-soluble) and glutelins (weak acid/weak base-soluble) [113, 114]. Globulin is the main component of SSP and can be classified into four groups according to different sedimentation coefficients, which are 2S (including trypsin inhibitors and cytochrome and other ingredients), 7S (β-conglycinin), 11S (glycinin) and 15S (polymer of glycinin) [115]. 7S and 11S are the main components of soybean seed storage protein, and they are accounting for 60–80% of the whole soybean seed storage protein [116, 117, 118, 119, 120]. Till now, about the genetic mechanisms of 7S and 11S, globulin subunits are clear in general [121, 122, 123, 124]. β-conglycinin is accounting for roughly 30–40% of the total seed protein and is mainly composed of α-(76kD), α ‘-(72kD) and β-(53kD) subunits [125, 126, 127]. Glycinin is accounting for roughly 40–60% of the total seed protein and is mainly composed of G1, G2, G3, G4 and G5 subunits (approximately 56, 54, 54, 64 and 58 kD, respectively) [113, 118, 128]. In the past several years, few QTL mapping researches were conducted for soybean seed 7S and 11S; the QTL region of 11S includes Gm09 45.6–47.6 Mb and 103.7–105.8 Mb, Gm17 79–81 Mb, Gm19 55.1–57.1 Mb, Gm19 60.3–62.35 Mb and Gm20 81.7–83.7 Mb [129]; the QTL region of 7S includes one QTL of α’-7S located on Gm08 35.7–37.7 Mb and nine QTLs of β-7S located on Gm01 65–104 Mb, Gm03 75.4–77.49 Mb, Gm17 26–81 Mb, Gm19 30–31 Mb, 100.7–115 Mb and Gm20 92–98 Mb [129, 130]. The genes of 11S and 7S have been reported, the genes of 11S subunit include
Accumulation of soybean seed storage protein is always coupling with TAGs and some key transcription factors involved in the process [144]. B3-type transcription factors can act directly on the expression of SSP genes [145]. The B3 domain, identified as the DNA-binding motif, recognizes the RY motif (CATGCA) as the target sequence [146], and RY motif (CATGCA) is a cis-acting element as a seed-specific promoter, which is the most legume seed storage protein gene that contain one or more RY repeating elements [65, 128]. Several studies have shown that the binding of the
1.4. Small RNA regulation of seed composition
Small RNAs, such as miRNAs and short interfering RNAs (siRNAs), are key components of the evolutionarily conserved system of gene regulation in eukaryotes [166]. Wherein, microRNAs (miRNAs) are a class of non-coding small RNAs of 20–24 nt in length that play an important role in plant growth and development. Structurally, except for the characteristics of the segments, all miRNA precursors have well-predicted stem-loop hairpin structures, and this fold-back hairpin structure has a low degree of freedom of energy [167]. The microRNA database (http://www.mirbase.org/) is a searchable database of published miRNA sequences and annotations. According to miRBase, miRNA information of 1269 species has been collected, including 399 soybean miRNAs. For example, gma-MIR156d belongs to the MIPF0000008, MIR156 gene family, described as
There are few studies on miRNAs related to plant quality. Soybean cotyledons affect soybean seed yield and quality. Goettel et al. analyzed 304 miRNA genes expressed in soybean cotyledons and predicted their complex miRNA networks to 1910 genes. By analyzing extensive biological pathways present in soybean cotyledons, the evolutionary pathways of soybean miR15/49 in soybean cotyledons were further demonstrated [170]. Ye et al. identified and analyzed the whole genome of miRNA endogenous target gene mimic (eTM) and the phagemid-generated siRNA (PHAS) in soybean, with a focus on lipid metabolism-related genes. Lipid metabolism was found to be regulated by a potentially complex non-coding network in soybean, of which 28 may be miRNA-regulated and nine may be further regulated [171].
2. Conclusion and perspectives
As sequencing development of soybean genome, the cultivar Williams 82 genome has been released by Schmutz et al. [172], and it update the quality of assembly of the reference genome year by year. In present version (
Although many genes and regulators of seed oil content and SSP have been identified and their associated regulatory networks have been well studied in Arabidopsis, there are still unclear in soybean in addition to
Acknowledgments
This study was supported by the National Key R&D Program of China (2016 YFD0100500, 2016YFD0100300, 2016YFD0100201-21), the National Natural Science Foundation of China (31701449, 31471516, 31401465, 31400074, 31501332), the Natural Science Foundation of Heilongjiang (QC2017013), the Young Innovative Talent training plan of undergraduate colleges and universities in Heilongjiang province (UNPYSCT-2016144), special financial aid to post-doctor research fellow in Heilongjiang (To Qi Zhaoming), the Heilongjiang Funds for Distinguished Young Scientists (JC2016004) and the Outstanding Academic Leaders Projects of Harbin, China (2015RQXXJ018), the China Post Doctoral Project (2015 M581419), the Dongnongxuezhe Project (to Chen Qingshan), the Young Talent Project (to Qi Zhaoming, 518062) of Northeast Agricultural University and SIPT project of Northeast Agriculture University (2018-171, 2018-172).
References
- 1.
Boland MJ, Rae AN, Vereijken JM, Meuwissen MPM, Fischer ARH, van Boekel MAJS, Rutherfurd SM, Gruppen H, Moughan PJ, Hendriks WH. The future supply of animal-derived protein for human consumption. Trends in Food Science & Technology. 2013; 29 :62-73. DOI: 10.1016/j.tifs.2012.07.002 - 2.
Wilcox JR. Breeding soybeans for improved oil quantity and quality. In: Shibles R, editor. Proc. 3rd World Soybean Res. 1985 - 3.
Burton JW. Breeding soybeans for improved protein quantity and quality. In: Shibles R, editor. Proceedings of the 3rd World Soybean Res. Conference. Westview Press, Boulder/CO. 1985. pp. 361-367 - 4.
Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newburg L. MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics. 1987; 1 :174-181. DOI: 10.1016/0888-7543(87)90010-3 - 5.
Lander ES, Botstein D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 1989; 121 :185-199 - 6.
Haley CS, Knott SA. A Simple dominant inheritance of a trait lacking β-conglycinin detected in a wild soybean line le regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity. 1992; 69 :315-324 - 7.
Jansen RC. Interval mapping of multiple quantitative trait loci. Genetics. 1993; 135 :205-211 - 8.
Rodolphe F, Lefort M. A multi-marker model for detecting chromosomal segments displaying QTL activity. Genetics. 1993; 134 :1277-1288 - 9.
Zeng ZB. Precision mapping of quantitative trait loci. Genetics. 1994; 136 :1457-1468 - 10.
Kao CH, Zeng ZB, Teasdale RD. Multiple interval mapping for quantitative trait loci. Genetics. 1999; 152 :1203-1216 - 11.
Meng L, Li H, Zhang L, Wang J. QTL IciMapping: Integrated software for genetic linkage map construction and quantitative trait locus mapping in biparental populations. The Crop Journal. 2015; 3 :269-283. DOI: 10.1016/j.cj.2015.01.001 - 12.
Chen QS, Mao XR, Zhang ZG, Zhu RS, Yin ZG, Leng Y, Yu HX, Jia HY, Jiang SS, Ni ZQ, Jiang HW, Han X, Liu CY, Hu ZB, Wu XX, Hu GH, Xin DW, Qi ZM. SNP-SNP interaction analysis on soybean oil content under multi-environments. PLoS One. 2016; 11 :e0163692. DOI: 10.1371/journal.pone.0163692 - 13.
Zhang YH, Liu MF, He JB, Wang YF, Xing GN, Li Y, Yang SP, Zhao TJ, Gai JY. Marker-assisted breeding for transgressive seed protein content in soybean [ Glycine max (L.) Merr.]. Theoretical and Applied Genetics. 2015;128 :1061-1072. DOI: 10.1007/s00122-015-2490-4 - 14.
Qi ZM, Pan JB, Han X, Qi HD, Xin DW, Li W, Mao XR, Wang ZY, Jiang HW, Liu CY, Hu ZB, Hu GH, Zhu RS, Chen QS. Identification of major QTLs and epistatic interactions for seed protein concentration in soybean under multiple environments based on a high-density map. Molecular Breeding. 2016; 36 :5. DOI: 10.1007/s11032-016-0475-x - 15.
Primary GGV. Secondary, and meta-analysis of research. Educational Researcher. 1976; 5 :3-8 - 16.
Goffinet B, Gerber S. Quantitative trait loci: A meta-analysis. Genetics. 2000; 155 :463-473 - 17.
Chardon F, Virlon B, Moreau L, Falque M, Joets J, Decousset L, Murigneux A, Charcosset A. Genetic architecture of flowering time in maize as inferred from quantitative trait loci meta-analysis and synteny conservation with the rice genome. Genetics. 2004; 168 :2169-2185. DOI: 10.1534/genetics.104.032375 - 18.
Guo B, Sleper DA, Lu P, Shannon JG, Nguyen HT, Arelli PR. QTLs associated with resistance to soybean cyst nematode in soybean: Meta-analysis of QTL location. Crop Science. 2006; 46 :595-602. DOI: 10.2135/cropsci2005.04-0036-2 - 19.
Qi ZM, Wu Q, Han X, Sun YN, Du XY, Liu CY, Jiang LH, Hu GH, Chen QS. Soybean oil content QTL mapping and integrating with meta-analysis method for mining genes. Euphytica. 2011; 179 :499-514. DOI: 10.1007/s10681-011-0386-1 - 20.
Qi ZM, Sun YN, Wu Q, Liu CY, Hu GH, Chen QS. A meta-analysis of seed protein concentration QTL in soybean. Canadian Journal of Plant Science. 2011; 91 :221-230. DOI: 10.1139/CJPS09193 - 21.
Johnson HW, Bernard RL. Soybean genetics and breeding. Advances in Agronomy. 1962; 14 :149-221. DOI: 10.1016/S0065-2113(08)60438-1 - 22.
Kwon SH, Torrie JH. Heritability of and interrelationships among traits of two soybean populations. Crop Science. 1989; 4 (2):482-488 - 23.
Burton JW. Quantitative genetics: Results relevant to soybean breeding. Agronomy (USA). 1987:45-64 - 24.
Johnson HW, Robinson HF, Comstock RE. Genotypic and phenotypic correlations in soybeans and their implications in selection. Agronomy Journal. 1955; 47 :477-483. DOI: 10.2134 - 25.
Hanson WD, Leffel RC, Howell RW. Genetic analysis of energy production in the soybean. Crop Science. 1961; 1 :121-126 - 26.
Smith RR, Weber CR. Mass selection by specific gravity for protein and oil in soybean populations. Crop Science. 1968; 8 :373-377. DOI: 10.2135/cropsci1968.0011183X000800030033x - 27.
Hartwig EE, Hinson K. Association between chemical composition of seed and seed yield of soybeans. Crop Science. 1972; 12 :829-830. DOI: 10.2135/cropsci1972.0011183X001200060034x - 28.
Shannon JG, Wilcox JR, Probst AH. Estimated gains from selection for protein and yield in the F4 generation of six soybean populations. Crop Science. 1972; 12 :824-826. DOI: 10.2135/cropsci1972.0011183X001200060032x - 29.
Brim CA, Caldwell BE, Howell RW. Soybeans: Improvement, production and uses. American Society of Agronom. 1973:681 p - 30.
Brim CA, Burton JW. Recurrent selection in soybeans. II. Selection for increased percent protein in seeds. Crop Science. 1979; 19 :494-498. DOI: 10.2135/cropsci1979.0011183X001900040016x - 31.
Sebern NA, Lambert JW. Effect of stratification for percent protein in two soybean populations. Crop Science. 1984; 24 :225-228. DOI: 10.2135/cropsci1984.0011183X002400020003x - 32.
Wehrmann VK, Fehr WR, Cianzio SR, Cavins JF. Transfer of high seed protein to high-yielding soybean cultivars. Crop Science. 1987; 27 :927-931. DOI: 10.2135/cropsci1987.0011183X002700050020x - 33.
Wilcox JR, Cavins JF. Backcrossing high seed protein to a soybean cultivar. Crop Science. 1995; 35 :1036-1041. DOI: 10.2135/cropsci1995.0011183X003500040019x - 34.
Cober ER, Voldeng DH. Developing high-protein, high-yield soybean populations and lines. Crop Science. 2000; 40 :39-42 - 35.
Thompson GA, Scherer DE, Foxall-Van Aken S, Kenney JW, Young HL, Shintani DK, Kridl JC, Knauf VC. Primary structures of the precursor and mature forms of stearoyl-acyl carrier protein desaturase from safflower embryos and requirement of ferredoxin for enzyme activity. Proceedings of the National Academy of Sciences. 1991; 88 :2578-2582. DOI: 10.1073/pnas.88.6.2578 - 36.
Orf, JH, Chase K, Jarvik T, Mansur LM, Cregan PB, Adler FR, Lark KG. Genetics of soybean agronomic traits: I. Comparison of three related recombinant inbred populations. Crop Science. 1999; 39 :1642-1651. DOI: 10.2135/cropsci1999.3961642x - 37.
Specht JE, Chase K, Macrander M, Graef GL, Chung J, Markwell JP, Germann M, Orf JH, Lark KG. Soybean response to water. Crop Science. 2001; 41 :493-509. DOI: 10.1104/pp.124.4.1752 - 38.
Hyten DL, Pantalone VR, Sams CE, Saxton AM, Landau-Ellis D, Stefaniak TR, Schmidt ME. Seed quality QTL in a prominent soybean population. Theoretical and Applied Genetics. 2004; 109 :552-561. DOI: 10.1007/s00122-004-1661-5 - 39.
Reinprecht Y, Poysa VW, Yu K, Rajcan I, Ablett GR, Pauls KP. Seed and agronomic QTL in low linolenic acid, lipoxygenase-free soybean ( Glycine max (L.) Merrill) germplasm. Genome. 2006;49 :1510-1527. DOI: 10.1139/g06-112 - 40.
Mao T, Jiang Z, Han Y, Teng W, Zhao X, Li W. Identification of quantitative trait loci underlying seed protein and oil contents of soybean across multi-genetic backgrounds and environments. Plant Breeding. 2013; 132 :630-641. DOI: 10.1111/pbr.12091 - 41.
Wang H, Guo J, Lambert K, Lin Y. Developmental control of Arabidopsis seed oil biosynthesis. Planta. 2007; 226 :773-783. DOI: 10.1007/s00425-007-0524-0 - 42.
Song B, Shen LW, Liu SS. Marker-assisted backcrossing of a null allele of the α-subunit of soybean ( Glycine max ) b-conglycinin with a Chinese soybean cultivar. Plant Breeding. 2014;133 :638-648. DOI: 10.1111/pbr.12203 - 43.
Liu YF, Li QT, Lu X, Song QX, Lam SM, Zhang WK, Ma B, Lin Q, Man WQ, Du WG, Shui GH, Chen SY, Zhang JS. Soybean GmMYB73 promotes lipid accumulation in transgenic plants. BMC Plant Biology. 2014; 14 :73. DOI: 10.1186/1471-2229-14-73 - 44.
Zhang YQ, Lu X, Zhao FY, Li QT, Niu SL, Wei W, Zhang WK, Ma B, Chen SY, Zhang JS. Soybean GmDREBL increases lipid content in seeds of transgenic Arabidopsis. Scientific Reports. 2016; 6 :34307. DOI: 10.1038/srep34307 - 45.
Zhang YQ, Lu X, Li QT, Chen SY, Zhang JS. Recent advances in identification and functional analysis of genes responsible for soybean nutritional quality. Scientia Agricultura Sinica. 2016; 49 :4299-4309 - 46.
Lu X, Li QT, Xiong Q, Li W, Bi YD, Lai YC, Liu XL, Man WQ, Zhang WK, Ma B, Chen SY, Zhang JS. The transcriptomic signature of developing soybean seeds reveals genetic basis of seed trait adaptation during domestication. The. Plant Journal. 2016; 86 :530-544. DOI: 10.1111/tpj.13181 - 47.
Li QT, Lu X, Song Q, Chen HW, Wei W, Tao JJ, Bi YD, Bian XH, Shen M, Ma B, Zhang WK, Li W, Lai YC, Lam SM, Shui GH, Chen SY, Zhang JS. Selection for a zinc-finger protein contributes to seed oil increase during soybean domestication. Plant Physiology. 2017; 173 :01610. DOI: 10.1104/pp.16.01610 - 48.
Sasaki Y, Nagano Y. Plant acetyl-CoA carboxylase: Structure, biosynthesis, regulation, and gene manipulation for plant breeding. Bioscience, Biotechnology, and Biochemistry. 2004; 68 :1175-1184. DOI: 10.1271/bbb.68.1175 - 49.
Slabas AR, Fawcett T. The biochemistry and molecular biology of plant lipid biosynthesis. Plant Molecular Biology. 1992; 19 :169-191. DOI: 10.1007/978-94-011-2656-4_11 - 50.
Ohlrogge J, Browse J. Lipid biosynthesis. The Plant Cell. 1995; 7 :957. DOI: 10.1105/tpc.7.7.957 - 51.
Harwood JL. Recent advances in the biosynthesis of plant fatty acids. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism. 1996; 1301 :7-56. DOI: 10.1016/0005-2760(95)00242-1 - 52.
Thelen JJ, Ohlrogge JB. Metabolic engineering of fatty acid biosynthesis in plants. Metabolic Engineering. 2002; 4 :12-21. DOI: 10.1006/mben.2001.0204 - 53.
Roesler K, Shintani D, Savage L, Boddupalli S, Ohlrogge J. Targeting of the Arabidopsis homomeric acetyl-coenzyme A carboxylase to plastids of rapeseeds. Plant Physiology. 1997; 113 :75-81. DOI: 10.1104/pp.113.1.75 - 54.
Zou J, Katavic V, Giblin EM, Barton DL, MacKenzie SL, Keller WA, Hu X, Taylor DC. Modification of seed oil content and acyl composition in the Brassicaceae by expression of a yeast sn-2 acyltransferase gene. The Plant Cell. 1997; 9 :909-923. DOI: 10.1105/tpc.9.6.909 - 55.
Jako C, Kumar A, Wei Y, Zou J, Barton DL, Giblin EM, Covello PS, Taylor DC. Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight. Plant Physiology. 2001; 126 :861-874. DOI: 10.1104/pp.126.2.861 - 56.
Vigeolas H, Waldeck P, Zank T, Geigenberger P. Increasing seed oil content in oil-seed rape ( Brassica napus L.) by over-expression of a yeast glycerol-3-phosphate dehydrogenase under the control of a seed-specific promoter. Plant Biotechnology Journal. 2007;5 :431-441. DOI: 10.1111/j.1467-7652.2007.00252.x - 57.
Kelly AA, Shaw E, Powers SJ, Kurup S, Eastmond PJ. Suppression of the SUGAR-DEPENDENT1 triacylglycerol lipase family during seed development enhances oil yield in oilseed rape ( Brassica napus L.). Plant Biotechnology Journal. 2013;11 :355-361. DOI: 10.1111/pbi.12021 - 58.
Kim M, Song JT, Bilyeu KD, Lee JD. A new low linolenic acid allele of GmFAD3A gene in soybean PE1690. Molecular Breeding. 2015; 35 :155. DOI: 10.1007/s11032-015-0352-z - 59.
Van Erp H, Kelly AA, Menard G, Peter JE. Multigene engineering of triacylglycerol metabolism boosts seed oil content in Arabidopsis. Plant Physiology. 2014; 165 :30-36. DOI: 10.1104/pp.114.236430 - 60.
Katavic V, Reed DW, Taylor DC, Giblin EM, Barton DL, Zou J, MacKenzie SL, Covello PS, Kunst L. Alteration of seed fatty acid composition by an ethyl methanesulfonate-induced mutation in Arabidopsis thaliana affecting diacylglycerol acyltransferase activity. Plant Physiology. 1995; 108 :399-409. DOI: 10.1104/pp.108.1.399 - 61.
Zhang M, Fan J, Taylor DC, Ohlrogge JB. DGAT1 and PDAT1 acyltransferases have overlapping functions in Arabidopsis triacylglycerol biosynthesis and are essential for normal pollen and seed development. The Plant Cell. 2009; 21 :3885-3901. DOI: 10.1105/tpc.109.071795 - 62.
Li M, Zhao M, Wu H, Wu W, Xu Y. Cloning, characterization and functional analysis of two type 1 diacylglycerol acyltransferases (DGAT1s) from Tetraena mongolica . Journal of Integrative Plant Biology. 2013;55 :490-503. DOI: 10.1111/jipb.12046 - 63.
Wang ZK, Huang WJ, Chang JM, Sebastian A, Li YG, Li HY, Wu XX, Zhang BB, Meng FL, Li WB. Overexpression of SiDGAT1, a gene encoding acyl-CoA: Diacylglycerol acyltransferase from Sesamum indicum L. increases oil content in transgenic Arabidopsis and soybean. The Plant Cell, Tissue and Organ Culture (PCTOC). 2014;119 :399-410. DOI: 10.1007/s11240-014-0543-z - 64.
Hatanaka T, Serson W, Li R, Armstrong P, Yu K, Pfeiffer T, Li X, Hildebrand D. A Vernonia Diacylglycerol Acyltransferase can increase renewable oil production. Journal of Agricultural and Food Chemistry. 2016; 64 :7188-7194. DOI: 10.1021/acs.jafc.6b02498 - 65.
Li H, Zhao T, Wang Y, Yu D, Chen S, Zhou R, Gai J. Genetic structure composed of additive QTL, epistatic QTL pairs and collective unmapped minor QTL conferring oil content and fatty acid components of soybeans. Euphytica. 2011; 182 :117. DOI: 10.1007/s10681-011-0524-9 - 66.
Guo L, Ma F, Wei F, Fanella B, Allen DK, Wang X. Cytosolic phosphorylating glyceraldehyde-3-phosphate dehydrogenases affect Arabidopsis cellular metabolism and promote seed oil accumulation. The Plant Cell. 2014; 26 :3023-3035. DOI: 10.1105/tpc.114.126946 - 67.
Wilson RF. Seed composition. In: Boerma HR, Specht JE, editors. Soybeans: Improvement. Production and Uses. 2004. pp. 621-677 - 68.
Zeng QY, Yang CY, Ma QB, Li XP, Dong WW, Nian H. Identification of wild soybean miRNAs and their target genes responsive to aluminum stress. BMC Plant Biology. 2012; 12 :182. DOI: 10.1186/1471-2229-12-182 - 69.
Panthee DR, Pantalone VR, Saxton AM. Modifier QTL for fatty acid composition in soybean oil. Euphytica. 2006; 152 :67-73. DOI: 10.1007/s10681-006-9179-3 - 70.
Diers BW, Shoemaker RC. Restriction fragment length polymorphism analysis of soybean fatty acid content. Journal of the American Oil Chemists Society. 1992; 69 :1242-1244. DOI: 10.1007/BF02637690 - 71.
Bachlava E, Dewey RE, Burton JW, Cardinal AJ. Mapping and comparison of quantitative trait loci for oleic acid seed content in two segregating soybean populations. Crop Science. 2009; 49 :433-442 - 72.
Xie D, Han Y, Zeng Y, Chang W, Teng W, Li W. SSR-and SNP-related QTL underlying linolenic acid and other fatty acid contents in soybean seeds across multiple environments. Molecular Breeding. 2012; 30 :169-179. DOI: 10.1007/s11032-011-9607-5 - 73.
Spencer MM, Landau-Ellis D, Meyer EJ, Pantalone VR. Molecular markers associated with linolenic acid content in soybean. Journal of the American Oil Chemists' Society. 2004; 81 :559-562. DOI: 10.2135/cropsci2001.412493x - 74.
Shibata M, Takayama K, Ujiie A, Yamada T, Abe J, Kitamura K. Genetic relationship between lipid content and linolenic acid concentration in soybean seeds. Breeding Science. 2008; 58 :361-366. DOI: 10.1270/jsbbs.58.361 - 75.
Li Z, Wilson RF, Rayford WE, Boerma HR. Molecular mapping genes conditioning reduced palmitic acid content in N87-2122-4 soybean. Crop Science. 2002; 42 :373-378. DOI: 10.2135/cropsci2002.3730 - 76.
Wang X, Jiang GL, Green M, Scott RA, Hyten DL, Cregan PB. Quantitative trait locus analysis of saturated fatty acids in a population of recombinant inbred lines of soybean. Molecular Breeding. 2012; 30 :1163-1179. DOI: 10.1007/s11032-012-9704-0 - 77.
Kim HK, Kim YC, Kim ST, Son BG, Choi YW, Kang JS, Choi IS, Park YH, Cho YS. Analysis of quantitative trait loci (QTLs) for seed size and fatty acid composition using recombinant inbred lines in soybean. Journal of Life Science. 2010; 20 :1186-1192. DOI: 10.5352/JLS.2010.20.8.1186 - 78.
McKeon T, Stumpf PK. Stearoyl-acyl carrier protein desaturase from safflower seeds. Methods in Enzymology. 1981; 71 :275-281 - 79.
Shanklin J, Somerville C. Stearoyl-acyl-carrier-protein desaturase from higher plants is structurally unrelated to the animal and fungal homologs. Proceedings of the National Academy of Sciences. 1991; 88 :2510-2514. DOI: 10.1073/pnas.88.6.2510 - 80.
Smith MA, Cross AR, Jones OTG, Griffiths WT, Stymne S, Stobart K. Electron-transport components of the 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine △12-desaturase (△12-desaturase) in microsomal preparations from developing safflower ( Carthamus tinctorius L.) cotyledons. Biochemical Journal. 1990;272 :23-29. DOI: 10.1042/bj2720023 - 81.
Schlueter JA, Vasylenko-Sanders IF, Deshpande S, Yi J, Siegfried M, Roe BA, Schlueter SD, Scheffler BE, Shoemaker RC. The FAD2 gene family of soybean. Crop Science. 2007; 47 :S-14. DOI: 10.2135/cropsci2006.06.0382tpg - 82.
Mathis L, Voytas DF, Zhang F, Haun W. U.S. Patent Application No. 14/208,027. 2014 - 83.
Wong CE, Zhao YT, Wang XJ, Croft L, Wang ZH, Haerizadeh F, Mattick JS, Singh MB, Carroll BJ, Bhalla PL. MicroRNAs in the shoot apical meristem of soybean. Journal of Experimental Botany. 2011; 62 :2495-2506. DOI: 10.1093/jxb/erq437 - 84.
Lakhssassi N, Zhou Z, Liu S, Colantonio V, AbuGhazaleh A, Meksem K. Characterization of the FAD2 gene family reveals the limitations of gel based TILLING in genes with high copy number. Frontiers in Plant Science. 2017; 8 :324 - 85.
Bilyeu KD, Palavalli L, Sleper DA, Beuselinck PR. Three microsomal omega-3 fatty-acid desaturase genes contribute to soybean linolenic acid levels. Crop Science. 2003; 43 :1833-1838. DOI: 10.1016/j.ydbio.2005.10.036 - 86.
Flores T, Karpova O, Su X, Zeng P, Bilyeu K, Sleper DA, Nguyen HT, Zhang ZJ. Silencing of GmFAD3 gene by siRNA leads to low α-linolenic acids (18:3) of fad3-mutant phenotype in soybean [ Glycine max (Merr.)]. Transgenic Research. 2008;17 :839-850. DOI: 10.1007/s11248-008-9167-6 - 87.
Hoshino T, Watanabe S, Takagi Y, Anai T. A novel GmFAD3-2a mutant allele developed through TILLING reduces α-linolenic acid content in soybean seed oil. Breeding Science. 2014; 64 :371-377. DOI: 10.1270/jsbbs.64.371 - 88.
Romero P, Rodrigo MJ, Alferez F, Ballester AR, Gonzalez-Candelas L, Zacarias L, Lafuente MT. Unravelling molecular responses to moderate dehydration in harvested fruit of sweet orange ( Citrus sinensis L. Osbeck) using a fruit-specific ABA-deficient mutant. Journal of Experimental Botany. 2012;63 :2753-2767. DOI: 10.1093/jxb/err461 - 89.
Shinozaki K, Yamaguchi-Shinozaki K. Molecular responses to dehydration and low temperature: Differences and cross-talk between two stress signaling pathways. Current Opinion in Plant Biology. 2000; 3 :217-223. DOI: 10.1016/S1369-5266(00)80068-0 - 90.
Cernac A, Benning C. WRINKLED1 encodes an AP2/EREB domain protein involved in the control of storage compound biosynthesis in Arabidopsis. The Plant Journal. 2004; 40 :575-585. DOI: 10.1111/j.1365-313X.2004.02235.x - 91.
Focks N, Benning C. Wrinkled1: A novel, low-seed-oil mutant of Arabidopsis with a deficiency in the seed-specific regulation of carbohydrate metabolism. Plant Physiology. 1998; 118 :91-101. DOI: 10.1104/pp.118.1.91 - 92.
Mu JY, Tan HL, Zheng Q, Fu FY, Liang Y, Zhang JA, Yang XH, Wang T, Chong K, Wang XJ, Zuo JR. LEAFY COTYLEDON1 is a key regulator of fatty acid biosynthesis in Arabidopsis. Plant Physiology. 2008; 148 :1042-1054. DOI: 10.1104/pp.108.126342 - 93.
Stone SL, Kwong LW, Yee KM, Pelletier J, Lepiniec L, Fischer R, Goldberg RB, Harada JJ. LEAFY COTYLEDON2 encodes a B3 domain transcription factor that induces embryo development. Proceedings of the National Academy of Science of the United States of America. 2001; 98 :11806-11811. DOI: 10.1073/pnas.201413498 - 94.
Giraudat J, Hauge BM, Valon C, Smalle J, Parcy F, Goodman HM. Isolation of the Arabidopsis ABI3 gene by positional cloning. The Plant Cell. 1992; 4 :1251-1261. DOI: 0.1105/tpc.4.10.1251 - 95.
Luerssen H, Kirik V, Herrmann P, Misera S. FUSCA3 encodes a protein with a conserved VP1/ABI3-like B3 domain which is of functional importance for the regulation of seed maturation in Arabidopsis thaliana. The Plant Journal. 1998; 15 :755-764. DOI: 10.1046/j.1365-313X.1998.00259.x - 96.
Lotan T, Ohto M, Yee KM, West MA, Lo R, Kwong RW, Yamagishi K, Fischer RL, Goldberg RB, Harada JJ. Arabidopsis LEAFY COTYLEDON1 is sufficient to induce embryo development in vegetative cells. Cell. 1998; 93 :1195-1205. DOI: 10.1016/S0092-8674(00)81463-4 - 97.
Baud S, Mendoza MS, To A, Harscoët E, Lepiniec L, Dubreucq B. WRINKLED1 specifies the regulatory action of LEAFY COTYLEDON2 towards fatty acid metabolism during seed maturation in Arabidopsis. The Plant Journal. 2017; 50 :825-838. DOI: 10.1111/j.1365-313X.2007.03092.x - 98.
Baud S, Wuilleme S, To A, Rochat C, Lepiniec L. Role of WRINKLED1 in the transcriptional regulation of glycolytic and fatty acid biosynthetic genes in Arabidopsis. The Plant Journal. 2009; 60 :933-947. DOI: 10.1111/j.1365-313X.2009.04011.x - 99.
An D, Kim H, Ju S, Go YS, Kim HU, Suh MC. Expression of Camelina WRINKLED1 isoforms rescue the seed phenotype of the Arabidopsis wri1 mutant and increase the triacylglycerol content in tobacco leaves. Frontiers in Plant Science. 2017; 8 :34. DOI: 10.3389/fpls.2017.00034 - 100.
Ivarson E, Leiva-Eriksson N, Ahlman A, Kanagarajan S, Bülow L, Zhu LH. Effects of overexpression of WRI1 and hemoglobin genes on the seed oil content of Lepidium campestre . Frontiers in Plant Science. 2016;7 :2032. DOI: 10.3389/fpls.2016.02032 - 101.
Sun RH, Ye RJ, Gao LC, Zhang L, Wang R, Mao T, Zheng YS, Li DD, Lin Y. Characterization and ectopic expression of CoWRI1, an AP2/EREBP domain-containing transcription factor from coconut ( Cocos nucifera L.) endosperm, changes the seeds oil content in transgenic Arabidopsis thaliana and Rice (Oryza sativa L.). Frontiers in Plant Science. 2017;8 :63. DOI: 10.3389/fpls.2017.00063 - 102.
Tsai AYL, Gazzarrini S. AKIN10 and FUSCA3 interact to control lateral organ development and phase transitions in Arabidopsis. Plant Journal. 2012; 69 :809-821. DOI: 10.1007/BF00398664 - 103.
Yagasaki K, Sakamoto H, Seki K, Yamada N, Takamatsu M, Taniguchi T, Takahashi K. Breeding of a new soybean cultivar “Nanahomare”. Hokuriku. Crop Science. 2010; 45 :61-64 - 104.
Shen B, Sinkevicius KW, Selinger DA, Tarczynski MC. The homeobox gene GLABRA2 affects seed oil content in Arabidopsis. Plant Molecular Biology. 2006; 60 :377-387. DOI: 10.1007/s11103-005-4110-1 - 105.
Zhang J, Hao Q, Bai L, Xu J, Yin W, Song L, Xu L, Guo X, Fan C, Chen Y, Ruan J, Hao S, Li Y, Wang RR, Hu Z. Overexpression of the soybean transcription factor GmDof4 significantly enhances the lipid content of Chlorella ellipsoidea. Biotechnology for Biofuels. 2014; 7 :128. DOI: 10.1186/s13068-014-0128-4 - 106.
Zhang D, Zhao M, Li S, Sun L, Wang W, Cai C, Dierking EC, Ma J. Plasticity and innovation of regulatory mechanisms underlying seed oil content mediated by duplicated genes in the palaeopolyploid soybean. The Plant Journal. 2017; 90 :1120-1133. DOI: 0.1111/tpj.13533 - 107.
Li D, Jin C, Duan S, Zhu Y, Qi S, Liu KG, Gao CH, Ma H L, Zhang M, Liao YC, Chen M. MYB89 transcription factor represses seed oil accumulation. Plant Physiology. 2016; 173 :01634. DOI: 10.1104/pp.16.01634 - 108.
Duan S, Jin C, Li D, Gao C, Qi S, Liu K, Hai JB, Ma HL, Chen M. MYB76 inhibits seed fatty acid accumulation in Arabidopsis. Frontiers in Plant Science. 2017; 8 :226. DOI: 10.3389/fpls.2017.00226 - 109.
Chen M, Wang Z, Zhu Y, Li Z, Hussain N, Xuan L, Guo W, Zhang G, Jiang L. The effect of transparent TESTA2 on seed fatty acid biosynthesis and tolerance to environmental stresses during young seedling establishment in Arabidopsis. Plant Physiology. 2012; 160 :1023-1036. DOI: 10.1104/pp.112.202945 - 110.
Mendes A, Kelly AA, van Erp H, Shaw E, Powers SJ, Kurup S, Eastmond PJ. bZIP 67 regulates the omega-3 fatty acid content of Arabidopsis seed oil by activating fatty acid desaturase3. The Plant Cell. 2013; 25 :3104-3116. DOI: 10.1105/tpc.113.116343 - 111.
Chen M, Zhang B, Li C, Kulaveerasingam H, Chew FT, Yu H. TRANSPARENT TESTA GLABRA1 regulates the accumulation of seed storage reserves in Arabidopsis. Plant Physiology. 2015; 169 :391-402 - 112.
Lee EJ, Oh M, Hwang JU, Li-Beisson Y, Nishida I, Lee Y. Seed-specific overexpression of the pyruvate transporter BASS2 increases oil content in Arabidopsis seeds. Frontiers in Plant Science. 2017; 8 :194. DOI: 10.3389/fpls.2017.00194 - 113.
Natarajan SS, Xu C, Bae H, Bailey BA, Cregan P, Caperna TJ, Garrette WM, Luthriaf D. Proteomic genetic analysis of glycinin subunits of sixteen soybean genotypes. Plant Physiology and Biochemistry. 2007; 45 :4366-4444. DOI: 10.1016/j.plaphy.2007.03.031 - 114.
Ferreira RB, Franco E, Teixeira AR. Calcium and magnesium-dependent aggregation of legume seed storage proteins. Journal of Agricultural and Food Chemistry. 1999; 47 :3009-3015. DOI: 10.1021/jf981151c - 115.
Peng IC, Quass DW, Dayton WR, Allen CE. Physicochemical and functional properties of soybean 11S globulin – A review. Cereal Chemistry. 1984; 61 :480-490. DOI: 没找到 - 116.
Derbyshire E, Wright DB, Boulter D. Legumin and vicilin, storage proteins of legume seeds. Phytochemistry. 1976; 15 :3-24. DOI: 10.1016/S0031-9422(00)89046-9 - 117.
Hill JE, Breidenbach RW. Proteins of soybean seeds I. Isolation and characterization of the major components. Plant Physiology. 1974; 53 :742-746. DOI: 10.1104/pp.53.5.742 - 118.
Biochemistry KHB. Molecular biology of soybean seed storage proteins. Journal of New Seeds. 2000; 2 :1-25. DOI: 10.1300/J153v02n03_01 - 119.
Krishnan HB, Oehrle NW, Natarajan SS. A rapid and simple procedure for the depletion of abundant storage proteins from legume seeds to advance proteome analysis: A case study using Glycine max . Proteomics. 2009;9 :3174-3188. DOI: 10.1002/pmic.200800875 - 120.
Thanh VH, Shibasaki K. Major proteins of soybean seeds. A straight forward fractionation and their characterization. Journal of Agricultural and Food Chemistry. 1976; 24 :1117-1121. DOI: 10.1021/jf60208a030 - 121.
Kitamura K, Davies CS, Nielsen NC. Inheritance of alleles for Cgy 1 and Gy 4 storage protein genes in soybean. TAG Theoretical and Applied Genetics. 1984; 68 :253-257. DOI: 10.1007/BF00266899 - 122.
Ladin BF, Doyle J, Beachy RN. Molecular characterization of a deletion mutation affecting the α’-subunit of β-conglycinin of soybean. Journal of Molecular and Applied Genetics. 1984; 2 :372-380 - 123.
Yagasaki K, Kaizuma N, Kitamura K. Inheritance of glycinin subunits and characterization of glycinin molecules lacking the subunits in soybean ( Glycine max (L.)Merr.). Japanese Journal of Breeding. 1996;46 :11-15. DOI: 10.1270/jsbbs1951.46.11 - 124.
Hajika M, Takahashi M, Sakai S, Matsunaga R. Dominant inheritance of a trait lacking β-conglycinin detected in a wild soybean line. Japanese Journal of Breeding. 1998; 48 :383-386. DOI: 10.1270/jsbbs1951.48.38366 - 125.
Koshiyama I, Gottschalk W, Muller HP, editors. Seed Proteins Biochemistry, Genetics, Nutritive Value (Advances in Agricultural Biotechnology). Dordrecht: Kluwer Academic Publishers; 1983. pp. 427-450 - 126.
Renkema JMS, Knabben JHM, Vliet T. Gel formation by b-conglycinin and glycinin and their mixtures. Food Hydrocolloids. 2001; 15 :407-414. DOI: 10.1016/S0268-005X(01)00051-0 - 127.
Tierney ML, Bray EA, Allen RD, Ma Y, Drong RF, Slightom J, Beachy RN. Isolation and characterization of a genomic clone encoding the b-subunit of b-conglycinin. Planta. 1987; 172 :356-363. DOI: 10.1007/BF00398664 - 128.
Nielsen NC, Dickinson CD, Cho TJ, Thanh VH, Scallon BJ, Fischer RL, Sims TL, Drews GN, Goldberg RB. Characterization of the glycinin gene family in soybean. The Plant Cell. 1989; 1 :313-328. DOI: 10.1105/tpc.1.3.313 - 129.
Panthee DR, Kwanyuen P, Sams CE, West DR, Saxton AM, Pantalone VR. Quantitative trait loci for β-conglycinin (7S) and glycinin (11S) fractions of soybean storage protein. Journal of the American Oil Chemists' Society. 2004; 81 :1005-1012. DOI: 10.1007/s11746-004-1014-4 - 130.
Ma Y, Kan G, Zhang X, Wang Y, Zhang W, Du H, Yu D. Quantitative trait loci (QTL) mapping for glycinin and β-conglycinin contents in soybean ( Glycine max L. Merr.). Journal of Agricultural and Food Chemistry. 2016;64 :3473-3483. DOI: 10.1021/acs.jafc.6b00167 - 131.
Nielsen NC, Bassüner R, Beaman T. The biochemistry and cell biology of embryo storage proteins. In: Brian AL, Indra KV, editors. Cellular and Molecular Biology of Plant Seed Development. Dordrecht, The Netherlands: Kluwer Academic Publishers; 1997. pp. 151-220. DOI: 10.1007/978-94-015-8909-3_5 - 132.
Harada JJ, Barker SJ, Goldberg RB. Soybean beta-conglycinin genes are clustered in several DNA regions and are regulated by transcriptional and posttranscriptional processes. The Plant Cell. 1989; 1 :415-425. DOI: 10.1105/tpc.1.4.415 - 133.
Beilinson V, Chen Z, Shoemaker R, Fischer R, Goldberg R, Nielsen N. Genomic organization of glycinin genes in soybean. Theoretical and Applied Genetics. 2002; 104 :1132-1140. DOI: 10.1007/s00122-002-0884-6 - 134.
Asakura T, Tamura T, Terauchi K, Narikawa T, Yagasaki K, Ishimaru Y, Abe K. Global gene expression profiles in developing soybean seeds. Plant Physiology and Biochemistry. 2012; 52 :147-153. DOI: 10.1016/j.plaphy.2011.12.007 - 135.
Withana-Gamage TS, Hegedus DD, Qiu X, Yu PQ, May T, Lydiate D, Wanasundara JPD. Characterization of Arabidopsis thaliana lines with altered seed storage protein profiles using synchrotron-powered FT-IR Spectromicroscopy. Journal of Agriculture and Food Chemistry. 2013; 6 :901-912. DOI: 10.1021/jf304328n - 136.
Wang J, Liu L, Guo Y, Wang YH, Zhang L, Jin LG, Guan RX, Liu ZX, Wang LL, Chang RZ, Qiu LJ. A dominant locus, qBSC-1, controls beta subunit content of seed storage protein in soybean ( Glycine max (L.) Merri.). Journal of Integrative Agriculture. 2014;13 :1854-1864. DOI: 10.1016/S2095-3119(13)60579-1 - 137.
Yamada T, Mori Y, Yasue K, Maruyama N, Kitamura K, Abe J. Knockdown of the 7S globulin subunits shifts distribution of nitrogen sources to the residual protein fraction in transgenic soybean seeds. The Plant Cell reports. 2014; 33 :1963-1976. DOI: 10.1007/s00299-014-1671-y - 138.
Utsumi S, Kinsella JE. Forces involved in soy protein gelation: Effects of various reagents on the formation, hardness and solubility of heat-induced gels made from 7S, 11S and soy isolate. Journal of Food Science. 1985; 50 :1278-1282. DOI: 10.1111/j.1365-2621.1985.tb10461.x - 139.
Wright DJ. The seed globulins. Developments in food. Proteins. 1987; 5 :81-157 - 140.
Ogawa T, Tayama E, Kitamura K, Kaizuma N. Genetic improvement of seed storage proteins using three variant alleles of 7S globulin subunits in soybean ( Glycine max L.). Japanese Journal of Breeding. 1989;39 :137-147. DOI: 10.1270/jsbbs1951.39.137 - 141.
Yang A, Yu X, Zheng A, James AT. Rebalance between 7S and 11S globulins in soybean seeds of differing protein content and 11SA4. Food Chemistry. 2016; 210 :148-155. DOI: 10.1016/j.foodchem.2016.04.095 - 142.
Takahashi M, Uematsu Y, Kashiwaba K, Yagasaki K, Hajika M, Matsunaga R, Komatsu K, Ishimoto M. Accumulation of high levels of free amino acids in soybean seeds through integration of mutations conferring seed protein deficiency. Planta. 2003; 217 :577-586. DOI: 10.1007/s00425-003-1026-3 - 143.
Tezuka M, Taira H, Igarashi Y, Yagasaki K, Ono T. Properties of tofus and soy milks prepared from soybeans having different subunits of glycinin. Journal of Agricultural and Food Chemistry. 2000; 48 :1111-1117. DOI: 10.1021/jf990560l - 144.
Santos-Mendoza M, Dubreucq B, Baud S, Parcy F, Caboche M, Lepiniec L. Deciphering gene regulatory networks that control seed development and maturation in Arabidopsis. The Plant Journal. 2008; 54 :608-620. DOI: 10.1111/j.1365-313X.2008.03461.x - 145.
Vicente-Carbajosa J, Carbonero P. Seed maturation: Developing an intrusive phase to accomplish a quiescent state. The International Journal of Developmental Biology. 2005; 49 :645-651. DOI: 10.1387/ijdb.052046jc - 146.
Che NY, Yang Y, Li YD, Wang LL, Huang P, Gao Y, An CC. Efficient LEC2 activation of OLEOSIN expression requires two neighboring RY elements on its promoter. Science in China Series C-Life Sciences. 2009; 52 :854-863. DOI: 10.1007/s11427-009-0119-z - 147.
Romanel EA, Schrago CG, Couñago RM, Russo CA, Alves-Ferreira M. Evolution of the B3 DNA binding superfamily: New insights into REM family gene diversification. PLoS One. 2009; 4 :e5791. DOI: 10.1371/journal.pone.0005791 - 148.
Sakata Y, Nakamura I, Taji T, Tanaka S, Quatrano RS. Regulation of the ABA-responsive Em promoter by ABI3 in the moss Physcomitrella patens : Role of the ABA response element and the RY element. Plant Signal. 2010;5 :1061-1066. DOI: 10.4161/psb.5.9.11774 - 149.
Delahaie J, Hundertmark M, Bove J, Leprince O, Rogniaux H, Buitink J. LEA polypeptide profiling of recalcitrant and orthodox legume seeds reveals ABI3-regulated LEA protein abundance linked to desiccation tolerance. Journal of Experimental Botany. 2013; 64 :4559-4573. DOI: 10.1093/jxb/ert274 - 150.
Du R, Qiao Y, Wang X, Lv X, Wang J. Establishment and analysis of the mRNA expression patterns of ABI3-like and storage protein genes during soybean seed development. Emirates Journal of Food and Agriculture. 2016; 28 :177 - 151.
Harada JJ. Role of Arabidopsis leafy cotyledon genes in seed development. Journal of Plant Physiology. 2001; 158 :405-409. DOI: 10.1078/0176-1617-00351 - 152.
Kirik V, Kölle K, Balzer HJ, Bäumlein H. Two new oleosin isoforms with altered expression patterns in seeds of the Arabidopsis mutant FUS3. Plant Molecular Biology. 1996; 31 :413-417. DOI: 10.1007/BF00021803 - 153.
To A, Valon C, Savino G, Guilleminotb J, Devicb M, Giraudata J, Parcy F. A network of local and redundant gene regulation governs Arabidopsis seed maturation. The Plant Cell. 2006; 18 :1642-1651. DOI: doi.org/10.1105/tpc.105.039925 - 154.
Crowe AJ, Abenes M, Plant A, Moloney MM. The seed-specific transactivator, ABI3, induces oleosin expression. Plant Science. 2000; 151 :171-181. DOI: 10.1016/S0168-9452(99)00214-9 - 155.
Soderman EM, Brocard IM, Lynch TJ, Finkelstein RR. Regulation and function of the Arabidopsis ABA-insensitive4 gene in seed and abscisic acid response signaling networks. Plant Physiology. 2000; 124 :1752-1765 - 156.
Ezcurra I, Wycliffe P, Nehlin L, Ellerstrom M, Rask L. Transactivation of the Brassica napus napin promoter by ABI3 requires interaction of the conserved B2 and B3 domains of ABI3 with different cis-elements: B2 mediates activation through an ABRE, whereas B3 interacts with an RY/G-box. The Plant Journal. 2000; 24 :57-66. DOI: 10.1046/j.1365-313x.2000.00857.x - 157.
Reidt W, Wohlfarth T, Ellerstrom M, Czihal A, Tewes A, Ezcurra I, Rask L, Baumlein H. Gene regulation during late embryogenesis: The RY motif of maturation-specific gene promoters is a direct target of the FUS3 gene product. The Plant Journal. 2000; 21 :401-440. DOI: 10.1046/j.1365-313x.2000.00686.x - 158.
Kroj T, Savino G, Valon C, Giraudat J, Parcy F. Regulation of storage protein gene expression in Arabidopsis. Development. 2003; 130 :6065-6073. DOI: 10.1242/dev.00814 - 159.
Braybrook SA, Stone SL, Park S, Bui AQ, Le BH, Fischer RL, Goldberg RB, Harada JJ. Genes directly regulated by LEAFY COTYLEDON2 provide insight into the control of embryo maturation and somatic embryogenesis. Proceeding of the National Academy of Science of the United States of America. 2006; 103 :3468-3473. DOI: 10.1073/pnas.0511331103 - 160.
Baud S, Boutin JP, Miquel M, Lepiniec L, Rochat C. An integrated overview of seed development in Arabidopsis thaliana ecotype WS. Plant Physiology Biochemistry. 2002; 40 :151-160. DOI: 10.1016/S0981-9428(01)01350-X - 161.
Kagaya Y, Toyoshima R, Okuda R, Usui H, Yamamoto A, Hattori T. LEAFY COTYLEDON1 controls seed storage protein genes through its regulation of FUSCA3 and ABSCISIC ACID INSENSITIVE3. Plant Cell Physiology. 2005; 46 :399-406. DOI: 10.1093/pcp/pci048 - 162.
Fatihi A, Boulard C, Bouyer D, Bauda S, Dubreucqa B, Lepinieca L. Deciphering and modifying LAFL transcriptional regulatory network in seed for improving yield and quality of storage compounds. Plant Science. 2016; 250 :198-204. DOI: 10.1016/j.plantsci.2016.06.013 - 163.
Abraham Z, Fernández RI, Martinez M, Diaz I, Carbonero P, Vicente-Carbajosa J. A developmental switch of gene expression in the barley seed mediated by HvVP1 (Viviparous1) and HvGAMYB interactions. Plant Physiology. 2016; 170 :2146-2158. DOI: 10.1104/pp.16.00092 - 164.
Baud S, Kelemen Z, Thévenin J, Boulard C, Blanchet S, To A, Payre M, Berger M, Effroy-Cuzzi D, Franco-Zorrilla JM, Godoy M, Solano R, Thevenon E, Parcy F, Lepiniec L, Dubreucq B. Deciphering the molecular mechanisms underpinning the transcriptional control of gene expression by L-AFL proteins in Arabidopsis seed. Plant Physiology. 2016; 171 :1099-1112. DOI: 10.1104/pp.16.00034 - 165.
Roesler K, Bermudez E, Damude HG, Li C, Meyer K, Shen B, Tarczynski MC. U.S. Patent Application, No. 15/239,069. 2016 - 166.
Carrington JC, Ambros V. Role of MicroRNAs in plant and animal development. Science. 2003; 301 :336-338. DOI: 10.1126/science.1085242 - 167.
Zhang B, Pan X, Cobb GP, Anderson TA. Plant microRNA: A small regulatory molecule with big impact. Developmental Biology. 2006; 289 :3-16. DOI: 10.1016/j.ydbio.2005.10.036 - 168.
Yu J, Zhang Z, Wei J, Ling Y, Xu Y, Su Z. SFGD: A comprehensive platform for mining functional information from soybean transcriptome data and its use in identifying acyl-lipid metabolism pathways. BMC Genomics. 2014; 15 :271. DOI: 10.1186/1471-2164-15-271 - 169.
Joshi T, Patil K, Fitzpatrick MR, Franklin LD, Yao Q, Cook JR, Wang Z, Libault M, Brechenmacher L, Valliyodan B, Wu X, Cheng J, Stacey G, Nguyen HT, Xu D. Soybean Knowledge Base (SoyKB): A web resource for soybean translational genomics. BMC Genomics. 2012; 13 :S15-S15. DOI: 10.1186/1471-2164-13-S1-S15 - 170.
Goettel W, Liu Z, Xia J, Zhang W, Zhao PX, An YQ. Systems and evolutionary characterization of microRNAs and their underlying regulatory networks in soybean cotyledons. PLoS One. 2014; 9 :e86153. DOI: 10.1371/journal.pone.0086153 - 171.
Ye CY, Xu H, Shen E, Liu Y, Wang Y, Shen Y, Qiu J, Zhu QH, Fan L. Genome-wide identification of non-coding RNAs interacted with microRNAs in soybean. Frontiers in Plant Science. 2014; 5 :743. DOI: 10.3389/fpls.2014.00743 - 172.
Schmutz J, Cannon SB, Schlueter J, Ma J, Mitros T, Nelson W, Hyten DL, Song Q, Thelen JJ, Cheng J, Xu D, Hellsten U, May GD, Yu Y, Sakurai T, Umezawa T, Bhattacharyya MK, Sandhu D, Valliyodan B, Lindquist E, Peto M, Grant D, Shu S, Goodstein D, Barry K, Futrell-Griggs M, Abernathy B, Du J, Tian Z, Zhu L, Gill N, Joshi T, Libault M, Sethuraman A, Zhang XC, Shinozaki K, Nguyen HT, Wing RA, Cregan P, Specht J, Grimwood J, Rokhsar D, Stacey G, Shoemaker RC, Jackson SA. Genome sequence of the palaeopolyploid soybean. Nature. 2010; 463 :178-183. DOI: 10.1038/nature08670 - 173.
Li MW, Xin D, Gao Y, Li KP, Fan K, Muñoz NB, Yung WS, Lam HM. Using genomic information to improve soybean adaptability to climate change. Journal of Experimental Botany. 2016:erw348. DOI: 10.1093/jxb/erw348