Open access peer-reviewed Edited Volume

New Insights into Systemic Sclerosis

Edited by Michal Tomcik

Charles University

Systemic sclerosis (scleroderma) is an incurable connective tissue disease of unknown etiology. Three key processes play a pivotal role in the pathogenesis: immune dysregulation and inflammation, endothelial injury and vasculopathy, and fibrosis. Tissue fibrosis is the dominant and characteristic feature that affects the skin and visceral organs. Life expectancy of scleroderma patients has improved over recent years, mainly because of better treatment of organ involvement and complications; however, no curative disease-modifying therapies exist to date. This book aims to provide students, trainees, rheumatologists, and other specialists interested in this disease with a comprehensive overview of novel pathogenetic mechanisms, management approaches, and therapeutic targets of several major vascular and fibrotic manifestations, and is useful insight into a number of usually neglected aspects of scleroderma.

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New Insights into Systemic SclerosisEdited by Michal Tomcik

Published: September 18th 2019

DOI: 10.5772/intechopen.78254

ISBN: 978-1-83962-205-2

Print ISBN: 978-1-83962-204-5

eBook (PDF) ISBN: 978-1-83962-206-9

Copyright year: 2019

Books open for chapter submissions

3335 Total Chapter Downloads

2 Crossref Citations

4 Dimensions Citations


Open access peer-reviewed

1. Advances in Management of Pulmonary Hypertension Associated with Systemic Sclerosis

By John W. Swisher and Shashank Kailash


Open access peer-reviewed

2. Renal Involvement in Systemic Sclerosis

By Tomas Soukup, Jan Toms, Sabina Oreska, Eva Honsova and Roman Safranek


Open access peer-reviewed

3. Gastrointestinal Involvement in Systemic Sclerosis: Overview, Neglected Aspects, Malnutrition, Body Composition and Management

By Sabina Oreska and Michal Tomcik


Open access peer-reviewed

4. Systemic Sclerosis Mimics

By Ondřej Kodet and Sabína Oreská


Open access peer-reviewed

5. Sexual Dysfunction in Patients with Systemic Sclerosis

By Barbora Heřmánková

Corrigendum to: Sexual Dysfunction in Patients with Systemic Sclerosis

By Barbora Heřmánková

Open access peer-reviewed

6. Biopsychosocial Aspects in Management of Scleroderma Patients

By Maja Špiritović


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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