Open access peer-reviewed Edited Volume

Muscular Dystrophy

Edited by Madhuri Hegde

Emory University, United States of America


Arunkanth Ankala

Emory University, United States of America

With more than 30 different types and subtypes known and many more yet to be classified and characterized, muscular dystrophy is a highly heterogeneous group of inherited neuromuscular disorders. This book provides a comprehensive overview of the various types of muscular dystrophies, genes associated with each subtype, disease diagnosis, management as well as available treatment options. Though each different type and subtype of muscular dystrophy is associated with a different causative gene, the majority of them have overlapping clinical presentations, making molecular diagnosis inevitable for both disease diagnosis as well as patient management. This book discusses the currently available diagnostic approaches that have revolutionized clinical research. Pathophysiology of the different muscular dystrophies, multifaceted functions of the involved genes as well as efforts towards diagnosis and effective patient management, are also discussed. Adding value to the book are the included reports on ongoing studies that show a promise for future therapeutic strategies.

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Muscular DystrophyEdited by Madhuri Hegde

Published: May 9th 2012

DOI: 10.5772/1242

ISBN: 978-953-51-0603-6

eBook (PDF) ISBN: 978-953-51-6994-9

Copyright year: 2012

Books open for chapter submissions

74429 Total Chapter Downloads

21 Crossref Citations

35 Web of Science Citations

48 Dimensions Citations


Open access peer-reviewed

1. Alpha-Dystroglycanopathy

By Mieko Yoshioka


Open access peer-reviewed

2. Nuclear Poly (A)-Binding Protein and Oculopharyngeal Muscular Dystrophy

By Jnanankur Bag, Quishan Wang and Rumpa Biswas Bhattacharjee


Open access peer-reviewed

3. Myotonic Dystrophy Type 1 (DM1): From the Genetics to Molecular Mechanisms

By Jonathan J. Magaña and Bulmaro Cisneros


Open access peer-reviewed

4. Possible Diverse Roles of Fukutin: More Than Basement Membrane Formation?

By Tomoko Yamamoto, Atsuko Hiroi, Yoichiro Kato, Noriyuki Shibata, Makiko Osawa and Makio Kobayashi


Open access peer-reviewed

5. Duchenne Muscular Dystrophy and Brain Function

By J.L. Anderson, S.I. Head and J.W. Morley


Open access peer-reviewed

6. Proteomic Analysis of Signalling Pathway Deregulation in Dystrophic Dog Muscle

By Marie Féron, Karl Rouger and Laetitia Guével


Open access peer-reviewed

7. Abnormal Ion Homeostasis and Cell Damage in Muscular Dystrophy

By Yuko Iwata and Shigeo Wakabayashi


Open access peer-reviewed

8. Mitogen-Activated Protein Kinases and Mitogen-Activated Protein Kinase Phosphatases in Regenerative Myogenesis and Muscular Dystrophy

By Hao Shi and Anton M. Bennett


Open access peer-reviewed

9. Synaptic Changes at the Spinal Cord Level and Peripheral Nerve Regeneration During the Course of Muscular Dystrophy in MDX Mice

By Gustavo Ferreira Simões and Alexandre Leite Rodrigues de Oliveira


Open access peer-reviewed

10. Altered Gene Expression Pathways in Duchenne Muscular Dystrophy

By Nevenka Juretić, Francisco Altamirano, Denisse Valladares and Enrique Jaimovich


Open access peer-reviewed

11. Effects of Dietary Phosphate on Ectopic Calcification and Muscle Function in mdx Mice

By Eiji Wada, Namiko Kikkawa, Mizuko Yoshida, Munehiro Date, Tetsuo Higashi and Ryoichi Matsuda


Open access peer-reviewed

12. Rehabilitation in Muscular Dystrophies: Changing Approach

By Imelda J.M. de Groot, Nicoline B.M. Voet, Merel Jansen and Lenie van den Engel-Hoek


Open access peer-reviewed

13. Database of Wards for Patients with Muscular Dystrophy in Japan

By Toshio Saito and Katsunori Tatara


Open access peer-reviewed

14. Diagnosis of the Muscular Dystrophies

By Leigh B. Waddell, Frances J. Evesson, Kathryn N. North, Sandra T. Cooper and Nigel F. Clarke


Open access peer-reviewed

15. Advances in Molecular Analysis of Muscular Dystrophies

By Arunkanth Ankala and Madhuri R. Hegde


Open access peer-reviewed

16. Motor Function Measure Scale (MFM): New Instrument for Follow-Up Brazilian Patients with Neuromuscular Disease

By Cristina Iwabe, Anamarli Nucci, Beatriz Helena Miranda Pfeilsticker and Luis Alberto Magna


Open access peer-reviewed

17. Strength and Functional Measurement for Patients with Muscular Dystrophy

By Yen-Mou Lu and Yi-Jing Lue


Open access peer-reviewed

18. Muscle Satellite Cells and Duchenne Muscular Dystrophy

By Yuko Miyagoe-Suzuki, So-ichiro Fukada and Shin'ichi Takeda


Open access peer-reviewed

19. Exon Skipping and Myoblast Transplantation: Single or Combined Potential Options for Treatment of Duchenne Muscular Dystrophy

By T. Iannitti, D. Lodi, V. Sblendorio, V. Rottigni and B. Palmieri


Open access peer-reviewed

20. Duchenne Muscular Dystrophy: Therapeutic Approaches to Restore Dystrophin

By Pietro Spitali and Annemieke Aartsma-Rus


Open access peer-reviewed

21. Stem Cell Based Therapy for Muscular Dystrophies: Cell Types and Environmental Factors Influencing Their Efficacy

By Jennifer Morgan and Hala Alameddine


Open access peer-reviewed

22. Genetic Therapy for Duchenne Muscular Dystrophy: Principles and Progress

By Taeyoung Koo, Linda Popplewell, Alberto Malerba and George Dickson


Open access peer-reviewed

23. From Basic Research to Clinical Trials: Preclinical Trial Evaluation in Mouse Models

By Sasha Bogdanovich and Emidio E. Pistilli


Open access peer-reviewed

24. A Two Stage Model of Skeletal Muscle Necrosis in Muscular Dystrophy - The Role of Fiber Branching in the Terminal Stage

By Stewart Head


Open access peer-reviewed

25. Myotonic Dystrophy Type 1: Focus on the RNA Pathology and Therapy

By Nikolaos P. Mastroyiannopoulos, Andrie Koutsoulidou and Leonidas A. Phylactou


Open access peer-reviewed

26. Duchenne Muscular Dystrophy: Experimental models on Physical Therapy

By Thais Gaiad, Karla Araujo, Fátima Caromano and Carlos Eduardo Ambrosio


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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